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Nanomaterials for Enzymatic Control of Oxidative Stress Toxicity and Free Radical Generation

Description du projet

Une nouvelle classe de nanozymes aux performances catalytiques améliorées

Les avancées récentes des nanotechnologies ont ouvert la voie à de nombreuses applications dans le domaine des biotechnologies et des soins de santé. Les progrès dans le domaine de la biocatalyse reposent sur le développement de nanozymes — des enzymes artificielles dotées de propriétés similaires à celles de vraies enzymes — présentant de meilleures performances catalytiques. Le défi consiste à améliorer la robustesse et la stabilité enzymatique tout en conservant les aspects inhérents aux enzymes tels que leur haute spécificité et leur faible toxicité. Financé par le programme Actions Marie Skłodowska-Curie, le projet NESTOR prévoit de synthétiser des nanozymes à atome unique basées sur des matériaux d’oxyde de fer polyvalents. La modélisation théorique devrait permettre aux scientifiques d’étudier les mécanismes microscopiques des sites actifs de type enzymatique. À terme, le projet évaluera l’impact toxicologique des nanozymes nouvellement synthétisées.

Objectif

Recent advances in nanotechnology have already provided excellent platforms to reshape many areas of biocatalysis and healthcare, and yet many challenges are still being faced to produce artificial nanozymes with better catalytic efficiency. Pending achievements include having enhanced enzymatic robustness and stability while keeping the key aspects of natural enzymes such as high specificity, low toxicity and bioavailability. Consequently, there is currently a real demand for better-designed nanozymes capable to solve these challenges for the different industrial and health requirements. NESTOR project aims to develop atomically-designed nanozymes based on versatile iron-oxide-based materials, to assess their true toxicological impact and to theoretically model the microscopic mechanisms of their enzymatic-like reactions (e.g. catalase-like, peroxidase-like, etc.) and to achieve a product-oriented enzymatic activity with minimum toxicological impact, a highly relevant societal concern. The outcomes from NESTOR project are expected to provide a better control of enzymatic reactions inside living entities together with the additional properties from the new materials such as magnetic actuability, imaging or heating. These research goals are embedded in the motivation of establishing a dynamic network with NESTOR, aimed to train the next generation of materials scientists, theoretical physicists, chemists, toxicologists and medical doctors in a highly interdisciplinary research environment so they can benchmark upcoming challenges concerning the new biomedical and environmental challenges to come. This next generation of open-minded scientists with true knowledge of multidisciplinary work will be an essential actor in the complex interactions between nanotechnologies and society that lay ahead.

Coordinateur

UNIVERSIDAD DE ZARAGOZA
Contribution nette de l'UE
€ 266 800,00
Adresse
Calle pedro cerbuna 12
50009 Zaragoza
Espagne

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Région
Noreste Aragón Zaragoza
Type d’activité
Higher or Secondary Education Establishments
Liens
Autres sources de financement
€ 0,00

Participants (3)

Partenaires (2)