INNOVATIVE WATER-SOLUBLE PHYTOMATERIAL INHIBITORs FOR ALZHEIMERs AND PARKINSONs DISEASES PREVENTION

Informazioni relative al progetto

PhytoAPP

ID dell’accordo di sovvenzione: 101007642

DOI

10.3030/101007642

Progetto chiuso

Data della firma CE 13 Ottobre 2020

Data di avvio 1 Marzo 2021

Data di completamento 28 Febbraio 2026

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 883 200,00

Contributo UE

€ 883 200,00

Coordinato da

COFAC COOPERATIVA DE FORMACAO E ANIMACAO CULTURAL CRL
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (6)

Summer School

Advance in Medical Science. It is planned. 8 lecturers, 30 participants. Duration 3 days.

Project Conference

Functional NMs for the Medical Application: Innovation and Challenges. It is planned 15 lecturers, 50 participants. Duration 3‑4 days.

3rd Workshop

Safety and Regulation of the Materials for the Medical Application. It is planned 5 lecturers, 30 participants.

Midterm meeting

Due to an extension Midterm with POREA will be aligned in 29 project month

1st Workshop

Innovative NMs for Medical Application It is planned Number 5 lecturers 15 participants

2nd Workshop

Engineering Design of Biobased Nanomaterials and NanoPharmaceuticals It is planned 5 lecturers 25 participants

Open Research Data Pilot (1)

Data Management Plan

Project Managament Plan will be prepared during first 6 months of the project summarising all the required knowledge for the good management of the project in terms of administrative forms financial aspects quality process etc

Documents, reports (7)

Dissemination and Communication Plans

Dissemination and Communication Plans will be worked out discussed and approved during the first meeting of consortium These plans will describe the Impact Maximization goals targets groups actions of the consortium and partners according to the appropriate time plan

PROTOCOL on in vitro Bioactivity Testing, NANOTOXICITY Assessment

Extended Bioactivity Testing: in vitro anti-viral, anti-oxidant; UV-protection of the PhytoAPP products Nanotoxicity assessment

Environmental RISK ASSESSMENT

Safety evaluation of the scaled up production, including environmental Risks assessment of the elaborated the nano-enabled Phytoproducts as nanopharmaceuticals in compliance with the legal requirements stipulated by Regulation (EC) 1223/2009 of EU

Operation MECHANISM SIMULATION

Development ofthe original software to adress fibrilation mechanism

KINETICS of the Amyloid Fibril Formation in a presence of elaborated Phytomaterials

Extended studies on kinetics of amyloid fibrils formation with novel products

PROTOCOL on in vivo PRECLINICAL STUDY

Rodent models of neurodegenerative disease in vivo studies and Brain Blood Barrier permeability studies

Protocol in vitro testing anti COVID 19

To adress COVID-19 emergency add objective NEUROPLAST (NL) will perform anti-virus test of novel water-soluble antioxidant Phytoproducts

Pubblicazioni

Peer reviewed articles (26)

Thiamine Compounds Alleviate Oxidative Stress, Over-Expression of Pro-Inflammatory Markers and Behavioral Abnormalities in a Mouse Predation Model of PTSD

Autori: Tatyana Strekalova, Anna Gorlova, Joao Costa-Nunes, Aleksandr Litavrin, Johannes P. M. de Munter, Alexei Lyundup, Aleksei Umriukhin, Andrey Proshin, Allan V. Kalueff, Edna Grünblatt, Susanna Walitza
Pubblicato in: International Journal of Molecular Sciences, Numero 26, 2025, Pagina/e 6627, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26146627

Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes

Autori: Evgeniy Svirin, Ekaterina Veniaminova, João Pedro Costa-Nunes, Anna Gorlova, Aleksei Umriukhin, Allan V. Kalueff, Andrey Proshin, Daniel C. Anthony, Andrey Nedorubov, Anna Chung Kwan Tse, Susanne Walitza, Lee Wei Lim, Klaus-Peter Lesch, Tatyana Strekalova
Pubblicato in: Cells, Numero 11, 2025, Pagina/e 1036, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/cells11061036

Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies

Autori: Anna Gorlova, Evgeniy Svirin, Dmitrii Pavlov, Raymond Cespuglio, Andrey Proshin, Careen A Schroeter, Klaus-Peter Lesch, Tatyana Strekalova
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2022, Pagina/e 915, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24020915

Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility

Autori: Careen A. Schroeter, Anna Gorlova, Michael Sicker, Aleksei Umriukhin, Alisa Burova, Boris Shulgin, Sergey Morozov, Joao P. Costa-Nunes, Tatyana Strekalova
Pubblicato in: Biomolecules, Numero 15, 2025, Pagina/e 67, ISSN 2218-273X
Editore: MDPI AG
DOI: 10.3390/biom15010067

Extraction of cellulose from rice straw by microwave irradiation

Autori: null Appazov, null Espanova, null Niyazova, null Moldanazar, null Zhapparbergenov, null Turmanov, null Toibazarova, null Appaz, null Syzdykbayev
Pubblicato in: Bulgarian Chemical Communications, Numero Volume 57, Numero 1, 2025, 2025, Pagina/e 14–19, ISSN 0861-9808
Editore: Bulgarian Chemical Society
DOI: 10.34049/bcc.57.1.5609

Utilization of Agricultural Waste into Terra Preta Biofertilizer and Its Impact on Crop Productivity

Autori: Nurbol Appazov; Altynkul Toibazarova; Rakhmetulla Zhapparbergenov; Gaini Taubekova; Zhainagul Yertayeva; Saken Kanzhar; Bekzhan Alimkhan; Magzhan Bekkhozhayev; Manas Serikbayev; Meruyert Tolegenkyzy; Dinara Niyazova; Indira Yespanova; Aidyn Appaz; Saltanat Appazova; Nurlybek O. Akhatayev; Bakhytbek Abzhalelov; Esenzhol Nazarov; Gulzat Askarova; Anipa Tapalova; Klara Darmagambet
Pubblicato in: Asian Journal of Green Chemistry, Numero Volume 10, Numero 2, 2026, Pagina/e 258–272, ISSN 2588-5839
Editore: Sami Publishing Company
DOI: 10.48309/ajgc.2026.543982.1822

Distinctive Effects of Fullerene C60 and Fullerenol C60(OH)24 Nanoparticles on Histological, Molecular and Behavioral Hallmarks of Alzheimer’s Disease in APPswe/PS1E9 Mice

Autori: Sholpan Askarova, Kseniia Sitdikova, Aliya Kassenova, Kirill Chaprov, Evgeniy Svirin, Andrey Tsoy, Johannes de Munter, Anna Gorlova, Aleksandr Litavrin, Aleksei Deikin, Andrey Nedorubov, Nurbol Appazov, Allan Kalueff, Anton Chernopiatko, Tatyana Strekalova
Pubblicato in: Antioxidants, Numero 14, 2025, Pagina/e 834, ISSN 2076-3921
Editore: MDPI AG
DOI: 10.3390/antiox14070834

Increased Oxidative Stress in the Prefrontal Cortex as a Shared Feature of Depressive- and PTSD-Like Syndromes: Effects of a Standardized Herbal Antioxidant

Autori: Johannes de Munter, Dmitrii Pavlov, Anna Gorlova, Michael Sicker, Andrey Proshin, Allan V. Kalueff, Andrey Svistunov, Daniel Kiselev, Andrey Nedorubov, Sergey Morozov, Aleksei Umriukhin, Klaus-Peter Lesch, Tatyana Strekalova, Careen A. Schroeter
Pubblicato in: Frontiers in Nutrition, Numero 8, 2023, Pagina/e Article 661455, ISSN 2296-861X
Editore: Frontiers Media SA
DOI: 10.3389/fnut.2021.661455

Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression

Autori: Tatyana Strekalova, Daniel Radford-Smith, Isobel K. Dunstan, Anna Gorlova, Evgeniy Svirin, Elisaveta Sheveleva, Alisa Burova, Sergey Morozov, Aleksey Lyundup, Gregor Berger, Daniel C. Anthony, Susanne Walitza
Pubblicato in: Neurobiology of Stress, Numero 31, 2024, Pagina/e 100646, ISSN 2352-2895
Editore: Elsevier BV
DOI: 10.1016/j.ynstr.2024.100646

Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer's disease

Autori: Ka Chun Tsui, Jaydeep Roy, Sze Chun Chau, Kah Hui Wong, Lei Shi, Chi Him Poon, Yingyi Wang, Tatyana Strekalova, Luca Aquili, Raymond Chuen-Chung Chang, Man-Lung Fung, You-Qiang Song, Lee Wei Lim
Pubblicato in: Frontiers Aging Neuroscience, Numero Jul 28;14:964336, 2022, Pagina/e 964336, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.964336

ASD-like behaviors, a dysregulated inflammatory response and decreased expression of PLP1 characterize mice deficient for sialyltransferase ST3GAL5

Autori: Tatyana Strekalova, Evgeniy Svirin, Ekaterina Veniaminova, Ekaterina Kopeikina, Tatyana Veremeyko, Amanda W.Y. Yung, Andrey Proshin, Susanne Walitza, Daniel C. Anthony, Lee Wei Lim, Klaus-Peter Lesch, Eugene D. Ponomarev
Pubblicato in: Brain, Behavior, & Immunity - Health, Numero 16, 2025, Pagina/e 100306, ISSN 2666-3546
Editore: Elsevier BV
DOI: 10.1016/j.bbih.2021.100306

Unraveling the structure–activity relationships of organometallic ferrocene-pyrazole and ferrocene-pyrimidine curcumin analogues in amyloid-β aggregation and glioblastoma treatment

Autori: Veronika Kovač, Veronika Huntosova, Viktoria Fedorova, Nikitas Georgiou, Jian-Zong Lai, Fan-Ching Chien, Shean-Jen Chen, Filip Dolenec, Katarina Siposova
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-23467-0

Therapeutic Effects of Neuro-Cells on Amyloid Pathology, BDNF Levels, and Insulin Signalling in APPswe/PSd1E9 Mice

Autori: Johannes P. J. M. de Munter, Andrey Tsoy, Kseniia Sitdikova, Erik Ch. Wolters, Kirill Chaprov, Konstantin B. Yenkoyan, Hamlet Torosyan, Sholpan Askarova, Daniel C. Anthony, Tatyana Strekalova
Pubblicato in: Cells, Numero 14, 2025, Pagina/e 1293, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/cells14161293

ISOLATION OF RICE HUSK OIL AND PREPARATION OF FATTY ACID MONOGLYCERIDES

Autori: null null, B.G. Alimkhan, S.A. Kanzhar, null null, A.S. Tapalova, null null, A.B. Toibazarova, null null, A.T. Shuragaziyeva, null null, N.A. Akhatayev, null null, B.B. Abzhalelov, null null, N.O. Appazov, null null
Pubblicato in: Chemical Journal of Kazakhstan, Numero Volume 4, Number 92 (2025), 2025, Pagina/e 41-51, ISSN 1813-1107
Editore: A.B. Bekturov Institute of Chemical Sciences
DOI: 10.51580/2025-4.2710-1185.49

Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice

Autori: Tatyana Strekalova, Dmitrii Pavlov, Alexander Trofimov, Daniel C. Anthony, Andrei Svistunov, Andrey Proshin, Aleksei Umriukhin, Alexei Lyundup, Klaus-Peter Lesch, Raymond Cespuglio
Pubblicato in: International Journal of Molecular Sciences, Numero 23, 2025, Pagina/e 2061, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23042061

Obtaining Sodium Aluminosilicate from Rice Husk

Autori: Nurbol O. Appazov , Meruyert Tolegenkyzy , Guldina E. Shudabay , Anel Serikkul, Neeraj Kumar , Sergiy Lyubchyk , Ziyada Zh. Appazova, Marat I.Syzdykbayev, Nurlybek A. Akhatayev, Esenzhol A. Nazarov, Bakytbek B.Abzhalelov, Gulzat Sh. Askarova , Assylkhan A. Shomantayev , Guldana S.Dairbekova , Artem L. Gushchin , Indira D. Yespanova , Dinara Zh. Niyazova, Rakhymzhan A. Turmanov, Rakhmetulla U. Zhap
Pubblicato in: Chemical Methodologies, Numero Volume 10, Numero 2, February 2026, 2026, Pagina/e 154–163, ISSN 2645-7776
Editore: Sami Publishing Company
DOI: 10.48309/chemm.2026.543429.2008

Extraction of Vegetable Oil from Rice Husk and Synthesis of Fatty Acid Monoglycerides

Autori: Nurbol O. Appazov, Anipa S. Tapalova, Bekzhan G. Alimkhan, Saken A. Kanzhar, Altynkul B. Toibazarova, Assel T. Shuragaziyeva, Banu M. Diyarova, Gulzat Sh. Askarova, Ziyada Zh. Appazova, Saltanat M. Appazova, Mukhtar N. Zhanakov, Gulmira M. Abyzbekova, Nurlybek A. Akhatayev, Esenzhol A. Nazarov, Bakytbek B. Abzhalelov
Pubblicato in: Chemical Methodologies, Numero Volume 10, Numero 1, 2026, Pagina/e 63–74, ISSN 2645-7776
Editore: Sami Publishing
DOI: 10.48309/chemm.2026.543433.2007

Immunomodulatory effects of new phytotherapy on human macrophages and TLR4- and TLR7/8-mediated viral-like inflammation in mice.

Autori: Schapovalova O., Gorlova A., de Munter J., Sheveleva E., Eropkin M., Gorbunov N., Sicker M., Umriukhin A., Lyubchyk S., Lesch K-P., Strekalova T. and Schroeter C.A
Pubblicato in: Front. Med.,Sec. Translational Medicine, 2022, ISSN 2296-858X
Editore: Frontiers Media S.A.
DOI: 10.3389/fmed.2022.952977

In FUS[1-359]-tg mice O,S-dibenzoyl thiamine reduces muscle atrophy, decreases glycogen synthase kinase 3 beta, and normalizes the metabolome

Autori: Probert F, Gorlova A, Deikin A, Bettendorff L, Veniaminova E, Nedorubov A, Chaprov KD, Ivanova TA, Anthony DC, Strekalova T.
Pubblicato in: Biomedicine and Pharmacotherapy, Numero 2022 Dec;156:113986, 2022, Pagina/e 113986, ISSN 1950-6007
Editore: Elsevier
DOI: 10.1016/j.biopha.2022.113986

Aberrant Ganglioside Functions to Underpin Dysregulated Myelination, Insulin Signalling, and Cytokine Expression: Is There a Link and a Room for Therapy?

Autori: Evgeniy Svirin, Johannes de Munter, Aleksei Umriukhin, Elisaveta Sheveleva, Allan V Kalueff, Andrei Svistunov, Sergey Morozov, Susanne Walitza, Tatyana Strekalova
Pubblicato in: Biomolecules, Numero Oct 7;12(10):1434, 2022, Pagina/e 1434, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom12101434

Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives

Autori: Tatyana Strekalova, Yanzhi Liu, Daniel Kiselev, Sharafuddin Khairuddin, Jennifer Lok Yu Chiu, Justin Lam, Ying-Shing Chan, Dmitrii Pavlov, Andrey Proshin, Klaus-Peter Lesch, Daniel C. Anthony, Lee Wei Lim
Pubblicato in: Psychopharmacology, Numero 239, 2024, Pagina/e 663-693, ISSN 0033-3158
Editore: Springer Verlag
DOI: 10.1007/s00213-021-05982-w

Monoglycerides of Fatty Acids Occurrence in Nature: Synthesis, Properties, and Uses

Autori: Nurbol Appazov, Bekzhan Alimkhan, Anipa Tapalova, Esenzhol Nazarov, Gulzat Askarova, Banu Diyarova
Pubblicato in: Journal of Chemical Reviews, Numero Vol. 8, Numero 2, 2026, Pagina/e 269–295, ISSN 2676-6868
Editore: Sami Publishing Company
DOI: 10.48309/jcr.2026.553725.1517

Neuro-Cells Mitigate Amyloid Plaque Formation and Behavioral Deficits in the APPswe/PS1dE9 Model of Alzheimer Disease While Also Reducing IL-6 Production in Human Monocytes

Autori: Johannes de Munter, Kirill Chaprov, Ekkehard Lang, Kseniia Sitdikova, Erik Ch. Wolters, Evgeniy Svirin, Aliya Kassenova, Andrey Tsoy, Boris W. Kramer, Sholpan Askarova, Careen A. Schroeter, Daniel C. Anthony, Tatyana Strekalova
Pubblicato in: Cells, Numero 14, 2025, Pagina/e 1168, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/cells14151168

SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors

Autori: Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova
Pubblicato in: Frontiers in Bioscience-Landmark, Numero 30, 2025, Pagina/e p. 26778, ISSN 2768-6701
Editore: IMR Press
DOI: 10.31083/fbl26778

Impact of Serotonin Transporter Absence on Brain Insulin Receptor Expression, Plasma Metabolome Changes, and ADHD-like Behavior in Mice fed a Western Diet

Autori: Daniel C. Anthony, Fay Probert, Anna Gorlova, Jenna Hebert, Daniel Radford-Smith, Zlata Nefedova, Aleksei Umriukhin, Andrey Nedorubov, Raymond Cespuglio, Boris Shulgin, Aleksey Lyundup, Klaus Peter Lesch, Tatyana Strekalova
Pubblicato in: Biomolecules, Numero 14, 2025, Pagina/e 884, ISSN 2218-273X
Editore: MDPI AG
DOI: 10.3390/biom14080884

Ultrasound- and magnetic field-triggered destruction of insulin- and lysozyme-derived amyloid fibrils via biogenic magnetosomes

Autori: Matus Molcan, Viktoria Fedorova, Michaela Romanovova, Rafał Bielas, Filip Ratajczak, Arkadiusz Józefczak, Katarina Siposova
Pubblicato in: Colloids and Surfaces B: Biointerfaces, Numero 264, 2026, Pagina/e 115670, ISSN 0927-7765
Editore: Elsevier BV
DOI: 10.1016/j.colsurfb.2026.115670