INNOVATIVE WATER-SOLUBLE PHYTOMATERIAL INHIBITORs FOR ALZHEIMERs AND PARKINSONs DISEASES PREVENTION

Informazioni relative al progetto

PhytoAPP

ID dell’accordo di sovvenzione: 101007642

DOI

10.3030/101007642

Data della firma CE 13 Ottobre 2020

Data di avvio 1 Marzo 2021

Data di completamento 28 Febbraio 2026

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 883 200,00

Contributo UE

€ 883 200,00

Coordinato da

COFAC COOPERATIVA DE FORMACAO E ANIMACAO CULTURAL CRL
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (6)

Summer School

Advance in Medical Science. It is planned. 8 lecturers, 30 participants. Duration 3 days.

Project Conference

Functional NMs for the Medical Application: Innovation and Challenges. It is planned 15 lecturers, 50 participants. Duration 3‑4 days.

3rd Workshop

Safety and Regulation of the Materials for the Medical Application. It is planned 5 lecturers, 30 participants.

Midterm meeting

Due to an extension Midterm with POREA will be aligned in 29 project month

1st Workshop

Innovative NMs for Medical Application It is planned Number 5 lecturers 15 participants

2nd Workshop

Engineering Design of Biobased Nanomaterials and NanoPharmaceuticals It is planned 5 lecturers 25 participants

Open Research Data Pilot (1)

Data Management Plan

Project Managament Plan will be prepared during first 6 months of the project summarising all the required knowledge for the good management of the project in terms of administrative forms financial aspects quality process etc

Documents, reports (6)

Dissemination and Communication Plans

Dissemination and Communication Plans will be worked out discussed and approved during the first meeting of consortium These plans will describe the Impact Maximization goals targets groups actions of the consortium and partners according to the appropriate time plan

PROTOCOL on in vitro Bioactivity Testing, NANOTOXICITY Assessment

Extended Bioactivity Testing: in vitro anti-viral, anti-oxidant; UV-protection of the PhytoAPP products Nanotoxicity assessment

Operation MECHANISM SIMULATION

Development ofthe original software to adress fibrilation mechanism

KINETICS of the Amyloid Fibril Formation in a presence of elaborated Phytomaterials

Extended studies on kinetics of amyloid fibrils formation with novel products

PROTOCOL on in vivo PRECLINICAL STUDY

Rodent models of neurodegenerative disease in vivo studies and Brain Blood Barrier permeability studies

Protocol in vitro testing anti COVID 19

To adress COVID-19 emergency add objective NEUROPLAST (NL) will perform anti-virus test of novel water-soluble antioxidant Phytoproducts

Pubblicazioni

Peer reviewed articles (5)

Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies

Autori: Anna Gorlova, Evgeniy Svirin, Dmitrii Pavlov, Raymond Cespuglio, Andrey Proshin, Careen A Schroeter, Klaus-Peter Lesch, Tatyana Strekalova
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2022, Pagina/e 915, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24020915

Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer's disease

Autori: Ka Chun Tsui, Jaydeep Roy, Sze Chun Chau, Kah Hui Wong, Lei Shi, Chi Him Poon, Yingyi Wang, Tatyana Strekalova, Luca Aquili, Raymond Chuen-Chung Chang, Man-Lung Fung, You-Qiang Song, Lee Wei Lim
Pubblicato in: Frontiers Aging Neuroscience, Numero Jul 28;14:964336, 2022, Pagina/e 964336, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.964336

Immunomodulatory effects of new phytotherapy on human macrophages and TLR4- and TLR7/8-mediated viral-like inflammation in mice.

Autori: Schapovalova O., Gorlova A., de Munter J., Sheveleva E., Eropkin M., Gorbunov N., Sicker M., Umriukhin A., Lyubchyk S., Lesch K-P., Strekalova T. and Schroeter C.A
Pubblicato in: Front. Med.,Sec. Translational Medicine, 2022, ISSN 2296-858X
Editore: Frontiers Media S.A.
DOI: 10.3389/fmed.2022.952977

In FUS[1-359]-tg mice O,S-dibenzoyl thiamine reduces muscle atrophy, decreases glycogen synthase kinase 3 beta, and normalizes the metabolome

Autori: Probert F, Gorlova A, Deikin A, Bettendorff L, Veniaminova E, Nedorubov A, Chaprov KD, Ivanova TA, Anthony DC, Strekalova T.
Pubblicato in: Biomedicine and Pharmacotherapy, Numero 2022 Dec;156:113986, 2022, Pagina/e 113986, ISSN 1950-6007
Editore: Elsevier
DOI: 10.1016/j.biopha.2022.113986

Aberrant Ganglioside Functions to Underpin Dysregulated Myelination, Insulin Signalling, and Cytokine Expression: Is There a Link and a Room for Therapy?

Autori: Evgeniy Svirin, Johannes de Munter, Aleksei Umriukhin, Elisaveta Sheveleva, Allan V Kalueff, Andrei Svistunov, Sergey Morozov, Susanne Walitza, Tatyana Strekalova
Pubblicato in: Biomolecules, Numero Oct 7;12(10):1434, 2022, Pagina/e 1434, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom12101434