In year 1 of HIPPOCRATES much of our effort was devoted to establishing the WP teams and consortium building. We've used a few innovative methods to build the teams including a 'team book' and tokens of recognition (see below) for exemplary individual contributions. Each of the four 'data gathering' WP teams (WP1-4) established detailed plans for prioritising sample cohorts and accessing samples including and identifying what data and analyses will be collected. Three cross-WP working groups covering Clinical Data Harmonisation (CDH), Imaging and Biomarkers supported these activities. In year 1, the initial discussions on the development of a HIPPOCRATES Data Sharing Agreement (DSA) began and included representatives of WPs 1-4 with significant contributions from the legal teams in UCD, the EFPIA partners, the Swiss Institute of Bioinformatics and the Fraunhofer. The DSA was signed by all partners in Oct 2023, and this represented a major achievement as it permitted consolidation of all HIPPOCRATES clinical and molecular data into a central database (the Secure HIPPOCRATES Data Management Platform (SHDMP) hosted at the Swiss Institute of Bioinformatics) with access to the data for all HIPPOCRATES partners. The DSA is supported by a consortium-wide Material Transfer Agreement to enable the sharing of biological samples. At the end of period 4, data from 14 cohorts totalling >7,600 patients, including multiple omics datasets have been uploaded to the SHDMP with plans to have all prioritised cohorts uploaded soon.
Most cohorts to be included within HIPPOCRATES are retrospective (already collected), but we have now made significant progress with recruiting participants to the HIPPOCRATES Prospective Observational Study (HPOS) which is part of WP2 on predicting Pso-PsA conversion. The study was launched in the UK and Ireland in Q3 2023, and Greece and Portugal in Q2, 2024. The study is being rolled-out to further EU countries. Currently, more than 4,700 people with psoriasis had been recruited.
Within WP2, a pilot study to identify molecular factors which may predict the development of PsA in people with psoriasis has been completed. Serum samples from people with psoriasis and no features of PsA, samples from people with psoriasis and perhaps some early PsA features as well as samples from people with established PsA (30 subjects in each group) were shared with 5 centres (UGLA, UMAN, KTH, FhG-CIMD and Atturos). Each centre analysed the samples and conducted initial data analysis. These study results were presented as an oral abstract at Europe’s main Rheumatology congress, 2024. Now that all these data are uploaded to the SHDMP and shared with data analysts at the Fraunhofer, combined machine learning and artificial intelligence approaches to data analysis is underway. All of this initial work is informing the best approach to be taken when combining molecular/clinical data generated in other WPs
As noted, 3 working groups have been established to facilitate cross-WP efforts related to CDH, Imaging, and Biomarkers. The working groups have each made substantial progress. Within the CDH working group, data managers from all HIPPOCRATES partners who are providing cohort data to the consortium (WP1-4) meet regularly and a HIPPOCRATES Glossary Expert group has developed a PsA glossary. To harmonize the glossary, these meetings have included input from the IMI BIOMAP team.
The Biomarker working group (with representatives from WP1-5) have mapped the detailed logistics for the planned multi-omic studies including sample types and volumes required as well as requirements for sample collection, processing, and storage. As noted before the Imaging Working group (involving mainly representatives from WP1 and WP3) has been incorporated into the Biomarker working group as have the activities of the data analysis teams and associated data analysis group meetings. The HIPPOCRATES Website is 'active' as are the Twitter, LinkedIn and BlueSky accounts. A communication Toolkit with resources has been developed. In total, there have been 41 peer reviewed publications and 59 presentations and posters (
https://www.hippocrates-imi.eu/publications(öffnet in neuem Fenster)).
