Health Initiatives in Psoriasis and PsOriatic arthritis ConsoRTium European States

Rezultaty

At the time point when 50% of the study population is expected to have been recruited, the beneficiary must submit to IMI JU a mid-term recruitment report. The report shall include an overview of recruited subjects by study site, potential recruiting problems and, if applicable, a detailed description of implemented and planned measures to compensate delays in the study subject recruitment.

Harmonised WP3 dataset available
Report on comparative evaluation of multiple imaging techniques
Clinical characteristics associated with structural and functional progression
HPOS: First study subject approvals package

HPOS Prior to enrolment of first study subject i Final version of study protocol as submitted toregulatorsethics committees ii Registration number of clinical study in a WHOor ICMJE approvedregistry with the possibility to post results iii Approvals ethics committees and national competentauthority if applicable required for invitationenrolment of first subject in at least one clinical centre

Establishing HPOS

Public project website
Communication Concept Plan

Publikacje

Machine learning identifies right index finger tenderness as key signal of DAS28-CRP based psoriatic arthritis activity

Autorzy: Samuel Rischke, Sorwe Mojtahed Poor, Robert Gurke, Lisa Hahnefeld, Michaela Köhm, Alfred Ultsch, Gerd Geisslinger, Frank Behrens, and Jörn Lötsch
Opublikowane w: Scientific Reports, Numer 13, Article number: 22710 (2023), 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-49574-4

ALISTER - Application for lipid stability evaluation and research

Autorzy: Samuel Rischke, Robert Gurke, Alexandre Bennett, Frank Behrens, Gerd Geisslinger, Lisa Hahnefeld
Opublikowane w: Clinica Chimica Acta, Numer Volume 557, 15 April 2024, 2024, Strona(/y) 117858, ISSN 1873-3492
Wydawca: Elsevier B.V.
DOI: 10.1016/j.cca.2024.117858

Application of Clinical and Molecular Profiling Data to Improve Patient Outcomes in Psoriatic Arthritis

Autorzy: Oliver FitzGerald, Frank Behrens, Anne Barton, Heidi Bertheussen, Bruno Boutouyrie-Dumont, Laura Coates, Owen Davies, Maarten de Wit, Filippo Fagni, Carl S Goodyear, Robert Gurke, Lisa Hahnfeld, Christine Huppertz, Vassilios Ioannidis, Mark Ibberson, Arnon Katz, Maximilian Klippstein, Michaela Koehm, Shimon Korish, Sina Mackay, David A. Martin, Denis O'Sullivan, Khadijah Patel, Stefan Rueping, Geo
Opublikowane w: Therapeutic Advances in Musculoskeletal Disease, Numer Volume 15, January-December 2023, 2023, ISSN 1759-7218
Wydawca: SAGE Publications
DOI: 10.1177/1759720x231192315

Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography

Autorzy: Tascilar K, Fagni F, Kleyer A, Bayat S, Heidemann R, Steiger F, Krönke G, Bohr D, Ramming A, Hartmann F, Klett D, Federle A, Regensburger AP, Wagner AL, Knieling F, Neurath MF, Schett G, Waldner M, Simon D.
Opublikowane w: Rheumatology (oxford), 2023, ISSN 1462-0332
Wydawca: Oxford University Press
DOI: 10.1093/rheumatology/keac346

DeepNAPSI multi-reader nail psoriasis prediction using deep learning

Autorzy: Lukas Folle, Pauline Fenzl, Filippo Fagni , Mareike Thies, Vincent Christlein, Christine Meder , David Simon , Ioanna Minnopoulou , Michael Sticherling , Georg Schett , Andreas Maier, Arnd Kleyer
Opublikowane w: Scientific Reports, 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-32440-8

"Deep Learning-Based Classification of Inflammatory Arthritis by Identification of Joint Shape Patterns-How Neural Networks Can Tell Us Where to ""Deep Dive"" Clinically."

Autorzy: Lukas Folle; David Simon; Koray Tascilar; Gerhard Krönke; Anna-Maria Liphardt; Andreas Maier; Georg Schett; Arnd Kleyer
Opublikowane w: Frontiers in Medicine, Numer 3, 2022, ISSN 0003-4967
Wydawca: BMJ Publishing Group
DOI: 10.3389/fmed.2022.850552

Small molecule biomarker discovery: Proposed workflow for LC-MS-based clinical research projects

Autorzy: S. Rischke, L. Hahnefeld, B. Burla, F. Behrens, R. Gurke, T.J. Garrett
Opublikowane w: Journal of Mass Spectrometry and Advances in the Clinical Lab, Numer Volume 28, April 2023, 2023, Strona(/y) 47-55, ISSN 2667-145X
Wydawca: Elevier B.V.
DOI: 10.1016/j.jmsacl.2023.02.003

Pre-analytical sample handling standardization for reliable measurement of metabolites and lipids in LC-MS-based clinical research

Autorzy: A. Sens, S. Rischke, L. Hahnefeld, E. Dorochow, S.M.G. Schäfer, D. Thomas, M. Köhm, G. Geisslinger, F. Behrens, R. Gurke
Opublikowane w: Journal of Mass Spectrometry and Advances in the Clinical Lab, Numer Volume 28, April 2023, 2023, Strona(/y) 35-46, ISSN 2667-145X
Wydawca: Elsevier B.V.
DOI: 10.1016/j.jmsacl.2023.02.002

OMICS and multi‐OMICS analysis for the early identification and improved outcome of patients with psoriatic arthritis

Autorzy: Robert Gurke Annika Bendes, John Bowes, Michaela Koehm, Richard M Twyman, Anne Barton, Carl Goodyear, Lisa Hahnefeld, Rainer Hillenbrand, Ewan Hunter, Mark Ibberson, Vassilios Ioannidis, Sabine Kugler, Eduard Resch, Stefan Rüping, Klaus Scholich, Jochen M Schwenk, James C Waddington, Phil Whitfield, Gerd Geißlinger, Oliver FitzGerald, Frank Behrens, and Stephen Pennington on behalf of the HIPPO
Opublikowane w: Biomedicines, 2022, ISSN 2227-9059
Wydawca: MDPI
DOI: 10.3390/biomedicines10102387

Anatomical pattern of entheseal and synovial fibroblast activation in psoriasis patients and its risk for developing psoriatic arthritis

Autorzy: Giulia Corte, Armin Atzinger, Selahattin Alp Temiz, Rita Noversa de Sousa, Melek Yalcin Mutlu, Verena Schoenau, Maria Gabriella Raimondo, Arnd Kleyer, Torsten Kuwert, Andreas Ramming, David Simon, Michael Sticherling, Christian Schmidkonz, Georg Schett and Filippo Fagni
Opublikowane w: RMD Open, Rheumatical and Muscoloskeletal Diseases, Numer Volume 10, Numer 2, 2024, Strona(/y) 10:e004294, ISSN 2056-5933
Wydawca: BMJ Publishing Group
DOI: 10.1136/rmdopen-2024-004294

Gut Inflammation in Axial Spondyloarthritis Patients is Characterized by a Marked Type 17 Skewed Mucosal Innatelike T Cell Signature

Autorzy: Céline Mortier, Katrien Quintelier, Ann-Sophie De Craemer, Thomas Renson, Liselotte Deroo, Emilie Dumas, Eveline Verheugen, Julie Coudenys, Tine Decruy, Zuzanna Lukasik, Sofie Van Gassen, Yvan Saeys, Anne Hoorens, Triana Lobaton, Filip Van den Bosch, Tom Van de Wiele, Koen Venken, and Dirk Elewaut
Opublikowane w: Arthritis & Rheumatology, Numer Vol 75, Numer 11, 2023, Strona(/y) 1969-1982, ISSN 2326-5205
Wydawca: Wiley & Sons
DOI: 10.1002/art.42627

Metabolomic and lipidomic fingerprints in inflammatory skin diseases - Systemic illumination of atopic dermatitis, hidradenitis suppurativa and plaque-type psoriasis

Autorzy: S. Rischke, S.M.G. Schäfer, A. König, T. Ickelsheimer, M. Köhm, L. Hahnefeld, A. Zaliani, K. Scholich, A. Pinter, G. Geisslinger, F. Behrens, R. Gurke
Opublikowane w: Clinical Immunology, Numer Volume 265 (2024), 2024, Strona(/y) 110305, ISSN 1521-7035
Wydawca: Elsevier B.V.
DOI: 10.1016/j.clim.2024.110305

Tolerability of low to moderate biomechanical stress during leisure sport activity in patients with psoriasis and psoriatic arthritis

Autorzy: Filippo Fagni, Melek Yalcin Mutlu, Selahattin Alp Temiz, Ioanna Minopoulou, Manuel Krieter, Georg Schett, Arnd Kleyer, David Simon and Axel J Hueber
Opublikowane w: RMD Open, Rheumatical and Muscoloskeletal Diseases, Numer Volume 9, Numer 4, 2023, Strona(/y) 9:e003612, ISSN 2056-5933
Wydawca: BMJ Publishing Group
DOI: 10.1136/rmdopen-2023-003612

Clinical, genetic and omics-based biomarkers that might support the identification of the development of psoriatic arthritis in individuals with psoriasis: a narrative review of the literature

Autorzy: Teresa Grohmann, Arani Vivekanantham, Laura C Coates, Stephen Pennington, Oliver FitzGerald
Opublikowane w: RMD Open, Numer 10, 2024, Strona(/y) e004176, ISSN 2056-5933
Wydawca: BMJ
DOI: 10.1136/rmdopen-2024-004176

Sequential interleukin-17/interleukin-23 inhibition in treatment-refractory psoriatic arthritis

Autorzy: David Simon, Filippo Fagni, Georg Schett
Opublikowane w: Ann Rheum Dis, 2022, ISSN 1468-2060
Wydawca: BMJ Publishing group
DOI: 10.1136/annrheumdis-2022-222415

Unveiling metabolic similarities of entheses in psoriasis and psoriatic arthritis patients using non-invasive in vivo imaging ? results from the MAPSA study

Autorzy: Filippo Fagni, Koray Tascilar, Rita Noversa de Sousa, Sara Bayat, Lukas Sollfrank, Arnd Kleyer, Michael Sticherling, Adrian P. Regensburger, Ferdinand Knieling, Markus F. Neurath, Georg Schett, Maximilian Waldner, David Simon
Opublikowane w: Arthritis & Rheumatology, Numer Vol. 0, No. 0, Month 2024, 2024, Strona(/y) 1–10, ISSN 2326-5205
Wydawca: Wiley Periodicals LLC on behalf of American College of Rheumatology
DOI: 10.1002/art.42917

Concise report: a minimal-invasive method to retrieve and identify entheseal tissue from psoriatic arthritis patients

Autorzy: Pachowsky ML, Raimondo MG, Xu C, Rauber S, Tascilar K, Labinsky H, Vogg M, Aziz Saad MS, Simon D, Rech J, Soare A, Braeuer L, Kleyer A, Schett G, Ramming A.
Opublikowane w: Ann Rheum Dis, 2021, ISSN 0003-4967
Wydawca: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-222061

HIPPOCRATES: improving diagnosis and outcomes in psoriatic arthritis.

Autorzy: FitzGerald, O., Pennington, S.R.
Opublikowane w: Nature Reviews Rheumatology, Numer 18 (3), 2022, ISSN 1759-4804
Wydawca: Nat Rev Rheumatol
DOI: 10.1038/s41584-022-00748-w

Deep learning-based classification of erosion, synovitis and osteitis in hand MRI of patients with inflammatory arthritis

Autorzy: Maja Schlereth, Melek Yalcin Mutlu, Jonas Utz, Sara Bayat, Tobias Heimann, Jingna Qiu, Chris Ehring, Chang Liu, Michael Uder, Arnd Kleyer, Frank Roemer, Georg Schett, Katharina Breininger and Filippo Fagni
Opublikowane w: RMD Open, Rheumatic and Muscoloskeletal Diseases, Numer Volume 10, Numer 2, 2024, Strona(/y) 10:e004273, ISSN 2056-5933
Wydawca: BMJ Publishing Group
DOI: 10.1136/rmdopen-2024-004273

Advanced neural networks for classification of MRI in psoriatic arthritis, seronegative, and seropositive rheumatoid arthritis

Autorzy: Lukas Folle; Sara Bayat; Arnd Kleyer; Filippo Fagni; Lorenz A Kapsner; Maja Schlereth; Timo Meinderink; Katharina Breininger; Koray Tascilar; Gerhard Krönke; Michael Uder; Michael Sticherling; Sebastian Bickelhaupt; Georg Schett; Andreas Maier; Frank Roemer; David Simon
Opublikowane w: Rheumatology, Numer 4, 2022, ISSN 1462-0332
Wydawca: BMJ Publishing group
DOI: 10.1093/rheumatology/keac197

Using Polygenic Risk Scores to Aid Diagnosis of Patients With Early Inflammatory Arthritis: Results From the Norfolk Arthritis Register

Autorzy: Ryan M. Hum, Seema D. Sharma, Michael Stadler, Sebastien Viatte, Pauline Ho, Nisha Nair, Chenfu Shi, Chuan Fu Yap, Mehreen Soomro, Darren Plant, Jenny H. Humphreys, Alexander MacGregor, Max Yates, Suzanne Verstappen, Anne Barton, John Bowes, on behalf of all NOAR collaborators
Opublikowane w: Arthritis & Rheumatology, Numer Volume76, Numer5, 2023, Strona(/y) 696-703, ISSN 2326-5205
Wydawca: Wiley Periodicals LLC on behalf of American College of Rheumatology
DOI: 10.1002/art.42760

Treatment response in Psoriatic Arthritis: A comparison between disease activity scores PsA Response Criteria and Disease Activity Score-28

Autorzy: Khadijah Patel, Nisha Nair, James Bluett, Meghna, Hector, Anne Barton, Philippa Curry
Opublikowane w: Rheumatology, Numer Volume 63, Numer Supplement_1, April 2024, keae163.056, 2024, ISSN 1462-0332
Wydawca: Oxford University Press for British Society for Rheumatology
DOI: 10.1093/rheumatology/keae163.056

OP0270 MICROSTRUCTURAL DAMAGE PROGRESSION OVER A 10-YEAR OBSERVATION PERIOD IN PATIENTS WITH PSORIATIC ARTHRITIS ASSESSED BY HIGH-RESOLUTION QUANTITATIVE PERIPHERAL COMPUTED TOMOGRAPHY: RESULTS FROM THE COMPACT STUDY

Autorzy: F. Fagni, K. Tascilar, L. Schuster, M. Yalcin Mutlu, S. A. Temiz, S. Bayat, O. Fitzgerald, S. R. Pennington, D. Martin, A. Kleyer, D. Simon, G. Schett
Opublikowane w: Scientific Abstracts, Numer 83:115-116, 2024
Wydawca: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.1273

POS0881 SPECIFIC AI-GENERATED PATTERN OF TENDER JOINTS AND TENDERNESS AT ENTHESIAL SITES ARE PREDICTIVE FOR OBJECTIVE DETECTION OF MUSCULOSKELETAL INFLAMMATION IN PSORIASIS PATIENTS

Autorzy: M. Köhm, A. Pick, H. Kratz, L. Zerweck, S. Kugler, S. Mackay, D. Antweiler, S. Rüping, F. Behrens
Opublikowane w: Scientific Abstracts, Numer Volume 82, Numer Suppl 1, 2023, ISSN 1468-2060
Wydawca: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2023-eular.4791

Assessment of psoriasis patients’ preferences for interventions to prevent psoriatic arthritis using a probabilistic threshold technique

Autorzy: Sam Groothuizen , Janne W. Bolt, Jorien Veldwijk, Laura C. Coates, Marie Falahee, Oliver FitzGerald, Stephen R. Pennington, Lisa G.M. Van Baarsen, Marleen G.H. Van de Sande
Opublikowane w: BMJ Journals, Annals of the Rheumatic Diseases, Numer Volume 83, Numer Suppl 1, 2024, ISSN 0003-4967
Wydawca: BMJ Journals
DOI: 10.1136/annrheumdis-2024-eular.1493

POS0974 MULTISPECTRAL OPTOACOUSTIC TOMOGRAPHY OF THE ENTHESES REVEALS COMMON METABOLIC PROFILES IN PSORIASIS AND PSORIATIC ARTHRITIS: RESULTS FROM THE MAPSA STUDY

Autorzy: F. Fagni, K. Tascilar, R. N. De Sousa, S. Bayat, L. Sollfrank, A. Kleyer, M. Sticherling, A. Regensburger, F. Knieling, M. F. Neurath, G. Schett, M. Waldner, D. Simon
Opublikowane w: Scientific Abstracts, Numer Volume 83, Numer Suppl 1, 2024
Wydawca: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.879

POS0242 68Ga-FAPI-04 PET/CT REVEALS INCREASED ENTHESEAL AND SYNOVIAL MESENCHYMAL ACTIVATION IN PSORIASIS PATIENTS AT RISK OF TRANSITION TO PSORIATIC ARTHRITIS

Autorzy: G. Corte, A. Atzinger, S. A. Temiz, R. N. De Sousa, V. Schönau, G. Raimondo, A. Kleyer, T. Kuwert, A. Ramming, D. Simon, M. Sticherling, C. Schmidkonz, G. Schett, F. Fagni
Opublikowane w: Scientific Abstracts, Numer Volume 83, Numer Suppl 1, 2024
Wydawca: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.800

OP0088 ENTHESEAL TISSUE SIGNATURE IN RESPONSE TO IL-17 BLOCKADE IN PSORIATIC ARTHRITIS - RESULTS FROM THE EBIO ENTHESIAL BIOPSY STUDY

Autorzy: M. G. Raimondo, H. Mohammadian, S. Alivernini, V. Fedorchenko, S. Rauber, H. Labinsky, M. Angeli, F. Fagni, G. Corte, K. Tascilar, L. Bräuer, M. A. D’Agostino, G. Schett, A. Kleyer, M. Pachowsky, A. Ramming
Opublikowane w: Scientific Abstracts, Numer Volume 83, Numer Suppl 1, 2024
Wydawca: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.4138

OP0308 MULTI-OMICS APPROACH TO THE IDENTIFICATION OF BIOMARKERS FOR PROGRESSION FROM PSORIASIS TO PSORIATIC ARTHRITIS

Autorzy: S. R. Pennington, J. Schwenk, A. Bendes, S. Rischke, R. Gurke, L. Hahnefeld, B. Kirby, L. C. Coates, O. Coleman, J. Waddington, R. Zhou, B. Wundervald, P. Whitfield, G. Blackburn, C. Regnault, A. Barton, J. Bowes, J. Bluett, O. Fitzgerald
Opublikowane w: Scientific Abstracts, Numer Volume 83, Numer Suppl 1, 2024, Strona(/y) 112.1-112, ISSN 0003-4967
Wydawca: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.2335

POS0273 A MACHINE LEARNING ALGORITHM BASED ON AUTOMATICALLY EXTRACTED IMAGE FEATURES AND CLINICAL DATA ON MORNING STIFFNESS CAN DISTINGUISH PSORIATIC ARTHRITIS PATIENTS FROM CONTROLS IN CLINICAL ROUTINE CARE

Autorzy: M. Köhm, L. Zerweck, T. A. Bergmann, H. Kratz, D. Antweiler, S. Kugler, S. Tsiami, M. Polyzou, X. Baraliakos, S. Ohrndorf, A. Barton, L. C. Coates, S. R. Pennington, O. Fitzgerald, F. Behrens, null null
Opublikowane w: Scientific Abstracts, Numer Volume 83, Numer Suppl 1, 2024, ISSN 1468-2060
Wydawca: BMJ Publishing Group Ltd and European League Against Rheumatism
DOI: 10.1136/annrheumdis-2024-eular.5205

Automated Hand Joint Classification of Psoriatic Arthritis Patients Using Routinely Acquired Near Infrared Fluorescence Optical Imaging

Autorzy: Lukas Zerweck, Stefan Wesarg, Jörn Kohlhammer, Michaela Köhm
Opublikowane w: Clinical Image-Based Procedures, Fairness of AI in Medical Imaging, and Ethical and Philosophical Numers in Medical Imaging, Lecture Notes in Computer Science, 2024, Strona(/y) 3-11, ISBN 978-3-031-45249-9
Wydawca: Springer Nature Switzerland
DOI: 10.1007/978-3-031-45249-9_1

Rezultaty

Publikacje

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