Skip to main content

Innovations to accelerate vaccine development and manufacture

Objective

Inno4Vac proposes an ambitious programme that will harness the latest advances in immunology, disease modelling, and modelling for tackling persistent scientific bottlenecks in vaccine development and for de-risking and accelerating this process. To reach this aim the project is divided into four interlinked subtopics. In Subtopic 1, artificial intelligence in combination with big data analysis and computational modelling will be used to build an open-access and cloud-based platform for in silico vaccine efficacy assessment and development. Subtopic 2 will develop new and improved controlled human infection models (CHIM) against influenza, RSV and C. difficile that will enable early vaccine efficacy evaluation. Subtopic 3 will contribute to the development of cell-based human in vitro 3D models that resemble the in vivo situation of an infection at the mucosa and more reliably predict immune protection. These models will be combined with the development of related functional immune assays for clinically relevant (surrogate) endpoints. Finally, Subtopic 4 will develop a modular one-stop computational platform for in silico modelling of vaccine bio-manufacturing and stability testing.
In parallel to the scientific-technical work, the partners will develop strategies and roadmaps for positioning the newly developed models in the regulatory framework and integrating them into pharmaceutical vaccine development. The overall workplan is underpinned by horizontal activities on coordination/management and dissemination/communication, including data management and future sustainability.
To achieve these ambitious objectives, Inno4Vacc has assembled a multidisciplinary consortium from academic and research institutions, industries, regulatory bodies, and vaccine R&D alliances. This unique partnership brings together clinical, immunological, microbiological, systems biology, mathematical models, and regulatory expertise and includes world-leaders in each respective field.

Call for proposal

H2020-JTI-IMI2-2020-20-two-stage
See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

EUROPEAN VACCINE INITIATIVE EWIV
Address
Vossstrasse 2 Geb 4040
69115 Heidelberg
Germany
Activity type
Research Organisations
EU contribution
€ 1 698 967,50

Participants (40)

SCLAVO VACCINES ASSOCIATION
Italy
EU contribution
€ 432 057,50
Address
Piazza La Lizza 7
53100 Siena
Activity type
Research Organisations
2-CONTROL APS
Denmark
EU contribution
€ 150 000
Address
Soldugvej 8
7400 Herning
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STICHTING CENTRE FOR HUMAN DRUG RESEARCH
Netherlands
EU contribution
€ 1 829 058,75
Address
Zernikedreef 8
2333 CL Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 438 483,75
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
ENPICOM BV
Netherlands
EU contribution
€ 298 750
Address
Sint Janssingel 88
5211 DA S-hertogenbosch
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FORSCHUNGSZENTRUM JULICH GMBH
Germany
EU contribution
€ 140 000
Address
Wilhelm Johnen Strasse
52428 Julich
Activity type
Research Organisations
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany
EU contribution
€ 353 625
Address
Inhoffenstrasse 7
38124 Braunschweig
Activity type
Research Organisations
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 1 818 097,50
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
INSILICO BIOTECHNOLOGY AG
Germany
EU contribution
€ 206 250
Address
Meitnerstrasse 9
70563 Stuttgart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INESC TEC - INSTITUTO DE ENGENHARIADE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIENCIA
Portugal
EU contribution
€ 298 750
Address
Rua Dr Roberto Frias Campus Da Feup
4200 465 Porto
Activity type
Research Organisations
ASSOCIATION INTERNATIONALE DE STANDARDISATION BIOLOGIQUE POUR L'EUROPE(IABS-EU)
France
EU contribution
€ 387 588,75
Address
24 Rue Jean Baldassini
69393 Lyon
Activity type
Other
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 2 345 772,50
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
LUNDS UNIVERSITET
Sweden
EU contribution
€ 175 000
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
MEYER CHROMA TECHNOLOGY APS
Denmark
EU contribution
€ 150 000
Address
Hollandsvej 5H St
2800 Kongens Lyngby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDICINES AND HEALTHCARE PRODUCTS REGULATORY AGENCY
United Kingdom
EU contribution
€ 516 426,25
Address
10 South Colonnade, Canary Wharf
E14 4PU London
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 400 070
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
BUNDESINSTITUT FUR IMPFSTOFFE UND BIOMEDIZINISCHE ARZNEIMITTEL
Germany
EU contribution
€ 437 131,25
Address
Paul-ehrlich-strasse 51-59
63225 Langen
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
PHARMALEX BELGIUM
Belgium
EU contribution
€ 430 000
Address
Rue Edouard Belin 5
1435 Mont Saint Guibert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SCIENSANO
Belgium
EU contribution
€ 377 147,50
Address
Juliette Wytsmanstraat 14
1050 Elsene
Activity type
Research Organisations
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 601 727,50
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT
Portugal
EU contribution
€ 97 731,25
Address
Campus De Caparica Faculdade De Ciencias E Tecnologia Da Universidade Nova De Lisboa
2829 516 Caparica
Activity type
Research Organisations
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 225 000
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Universitätsklinikum Jena
Germany
EU contribution
€ 125 000
Address
Bachstraße 18
07743 Jena
Activity type
Higher or Secondary Education Establishments
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 366 490
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 292 533,75
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
UNIVERSITETET I BERGEN
Norway
EU contribution
€ 752 593,75
Address
Museplassen 1
5020 Bergen
Activity type
Higher or Secondary Education Establishments
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 222 920
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 120 266,25
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
UNIVERSITETET I OSLO
Norway
EU contribution
€ 787 147,50
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 366 962,50
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 489 241,25
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 506 251,25
Address
Bunteweg 2
30559 Hannover
Activity type
Higher or Secondary Education Establishments
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany
EU contribution
€ 331 641,25
Address
Sanderring 2
97070 Wuerzburg
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 142 616,25
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
VIROCLINICS BIOSCIENCES BV
Netherlands
EU contribution
€ 160 000
Address
Marconistraat 16
3029 AK Rotterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
VISMEDERI SRL
Italy
EU contribution
€ 128 701,25
Address
Strada Del Petriccio E Belriguardo 35
53100 Siena Si
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GLAXOSMITHKLINE BIOLOGICALS SA
Belgium
EU contribution
€ 0
Address
Rue De L Institut 89
1330 Rixensart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI PASTEUR SA
France
EU contribution
€ 0
Address
14 Espace Henry Vallee
69007 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TAKEDA PHARMACEUTICALS INTERNATIONAL AG
Switzerland
EU contribution
€ 0
Address
Thurgauerstrasse 130
8152 Glattpark
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CUREVAC AG
Germany
EU contribution
€ 0
Address
Friedrich-miescher-strasse 15
72076 Tubingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)