Innovations to accelerate vaccine development and manufacture

Project Information

Inno4Vac

Grant agreement ID: 101007799

DOI

10.3030/101007799

EC signature date 19 July 2021

Start date 1 September 2021

End date 28 February 2027

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 39 342 552,00

EU contribution

€ 18 600 000,00

Coordinated by

EUROPEAN VACCINE INITIATIVE E.V
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (6)

Scientific consensus docon new challenge influenza strains
Roadmap document prioritizing RSV immune assays for development and standardization
Report of regulatory workshop 1
Prepare SOPs for handling open calls process
Workshops with stakeholders implemented
Open call process launched

Other (1)

Launch of web site

Publications

Non-peer reviewed articles (6)

Training data composition determines machine learning generalization and biological rule discovery

Author(s): Eugen Ursu, Aygul Minnegalieva, Puneet Rawat, Maria Chernigovskaya, Robi Tacutu, Geir Kjetil Sandve, Philippe A. Robert, Victor Greiff
Published in: bioRxiv, 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.06.17.599333

Simulation of adaptive immune receptors and repertoires with complex immune information to guide the development and benchmarking of AIRR machine learning

Author(s): Maria Chernigovskaya, Milena Pavlović, Chakravarthi Kanduri, Sofie Gielis, Philippe A. Robert, Lonneke Scheffer, Andrei Slabodkin, Ingrid Hobæk Haff, Pieter Meysman, Gur Yaari, Geir Kjetil Sandve, Victor Greiff
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.10.20.562936

Systematic benchmarking of mass spectrometry-based antibody sequencing reveals methodological biases

Author(s): Maria Chernigovskaya, Khang Lê Quý, Maria Stensland, Sachin Singh, Rowan Nelson, Melih Yilmaz, Konstantinos Kalogeropoulos, Pavel Sinitcyn, Anand Patel, Natalie Castellana, Stefano Bonissone, Stian Foss, Jan Terje Andersen, Geir Kjetil Sandve, Timothy Patrick Jenkins, William S. Noble, Tuula A. Nyman, Igor Snapkow, Victor Greiff
Published in: bioRxiv, 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.11.11.622451

Weakly supervised identification and generation of adaptive immune receptor sequences associated with immune disease status

Author(s): Andrei Slabodkin, Ludvig M. Sollid, Geir Kjetil Sandve, Philippe A. Robert, Victor Greiff
Published in: bioRxiv, 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.09.24.558823

InSilicoSeq 2.0: Simulating realistic amplicon-based sequence reads

Author(s): Stefan H. Lelieveld, Thijs Maas, Tessa C. X. Duk, Hadrien Gourlé, Henk-Jan van den Ham
Published in: bioRxiv, 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.16.580469

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood

Author(s): Puneet Rawat, Melanie R. Shapiro, Leeana D. Peters, Michael Widrich, Koshlan Mayer-Blackwell, Keshav Motwani, Milena Pavlović, Ghadi al Hajj, Amanda L. Posgai, Chakravarthi Kanduri, Giulio Isacchini, Maria Chernigovskaya, Lonneke Scheffer, Kartik Motwani, Leandro Octavio Balzano-Nogueira, Camryn M. Pettenger-Willey, Sebastiaan Valkiers, Laura M. Jacobsen, Michael J. Haller, Desmond A. Schatz, Cli
Published in: medRxiv, 2025, ISSN 3067-2007
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.12.10.24318751

Peer reviewed articles (24)

Reading the repertoire: Progress in adaptive immune receptor analysis using machine learning

Author(s): Timothy J. O’Donnell, Chakravarthi Kanduri, Giulio Isacchini, Julien P. Limenitakis, Rebecca A. Brachman, Raymond A. Alvarez, Ingrid H. Haff, Geir K. Sandve, Victor Greiff
Published in: Cell Systems, Issue 15, 2024, Page(s) 1168-1189, ISSN 2405-4712
Publisher: Elsevier BV
DOI: 10.1016/j.cels.2024.11.006

Symptoms and adverse events in controlled human infection models

Author(s): Karen Götz, Poleta Luga, Jörg Rengel, Mei Masur, Marcela Juárez-Hernández, Isabelle Bekeredjian-Ding
Published in: Frontiers in Medicine, Issue 12, 2025, ISSN 2296-858X
Publisher: Frontiers Media SA
DOI: 10.3389/fmed.2025.1578560

Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies

Author(s): Camilla T. Ekanger, Nilima Dinesh Kumar, Rosanne W. Koutstaal, Fan Zhou, Martin Beukema, Joanna Waldock, Simon P. Jochems, Noa Mulder, Cécile A. C. M. van Els, Othmar G. Engelhardt, Nathalie Mantel, Kevin P. Buno, Karl Albert Brokstad, Agnete S. T. Engelsen, Rebecca J. Cox, Barbro N. Melgert, Anke L. W. Huckriede, Puck B. van Kasteren
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1532144

Inno4Vac Workshop Report Part 1: Controlled Human Influenza Virus Infection Model (CHIVIM) Strain Selection and Immune Assays for CHIVIM Studies, November 2021, MHRA, UK

Author(s): Joanna Waldock, Rebecca J. Cox, Christopher Chiu, Kanta Subbarao, Adrian Wildfire, Wendy Barclay, Puck B. van Kasteren, John McCauley, Colin A. Russell, Derek Smith, Ryan S. Thwaites, John S. Tregoning, Othmar G. Engelhardt
Published in: Influenza and Other Respiratory Viruses, Issue 18, 2024, ISSN 1750-2640
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/irv.70014

Advancing regulatory dialogue: In silico models for improved vaccine biomanufacturing - an expert meeting report

Author(s): Irina Meln, Wim Van Molle, Mónica Perea Vélez, Greger Abrahamsen, Koen Brusselmans, Eric Calvosa, Antonio Gaetano Cardillo, Didier Clénet, Caroline Forestieri, Krist V. Gernaey, Marcel Hoefnagel, John Bagterp Jorgensen, Pierre Lebrun, Laurent Natalis, Bernt Nilsson, Volker Öppling, Julius Carl Pollinger, Andrea C.M.E. Rayat, Daniel Reem, Michelle Rubbrecht, Johannes Schmölder, Timothy Schofie
Published in: Vaccine, Issue 56, 2025, Page(s) 127170, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2025.127170

CADET-Julia: Efficient and versatile, open-source simulator for batch chromatography in Julia

Author(s): Jesper Frandsen, Jan Michael Breuer, Johannes Schmölder, Jakob Kjøbsted Huusom, Krist V. Gernaey, Jens Abildskov, Eric von Lieres
Published in: Computers & Chemical Engineering, Issue 192, 2024, Page(s) 108913, ISSN 0098-1354
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compchemeng.2024.108913

Fourth Controlled Human Infection Model (CHIM) meeting – CHIMs in endemic countries, May 22–23, 2023

Author(s): Melissa Kapulu, Lucinda Manda-Taylor, Shobana Balasingam, Gary Means, Mikal Ayiro Malungu, Philip Bejon, Primus Che Chi, Christopher Chiu, E. Chandler Church, Rodrigo Correa-Oliveira, Nicholas Day, Anna Durbin, Moses Egesa, Claudia Emerson, Kondwani Jambo, Roli Mathur, Wolfram Metzger, Noni Mumba, Winfred Nazziwa, Ally Olotu, Jacqueline Rodgers, Frank Sinyiza, Kawsar Talaat, Ingrid Kamerling, Char
Published in: Biologicals, Issue 85, 2024, Page(s) 101747, ISSN 1045-1056
Publisher: Academic Press
DOI: 10.1016/j.biologicals.2024.101747

Solving crystallization/precipitation population balance models in CADET, part I: Nucleation growth and growth rate dispersion in batch and continuous modes on nonuniform grids

Author(s): Wendi Zhang, Todd Przybycien, Johannes Schmölder, Samuel Leweke, Eric von Lieres
Published in: Computers & Chemical Engineering, Issue 183, 2024, Page(s) 108612, ISSN 0098-1354
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compchemeng.2024.108612

Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling

Author(s): Khang Lê Quý, Maria Chernigovskaya, Maria Stensland, Sachin Singh, Jinwoo Leem, Santiago Revale, David A. Yadin, Francesca L. Nice, Chelsea Povall, Danielle H. Minns, Jacob D. Galson, Tuula A. Nyman, Igor Snapkow, Victor Greiff
Published in: npj Systems Biology and Applications, Issue 10, 2024, ISSN 2056-7189
Publisher: Springer Nature
DOI: 10.1038/s41540-024-00402-z

NetTCR-struc, a structure driven approach for prediction of TCR-pMHC interactions

Author(s): Sebastian N. Deleuran, Morten Nielsen
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1616328

Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability

Author(s): Habib Bashour, Eva Smorodina, Matteo Pariset, Jahn Zhong, Rahmad Akbar, Maria Chernigovskaya, Khang Lê Quý, Igor Snapkow, Puneet Rawat, Konrad Krawczyk, Geir Kjetil Sandve, Jose Gutierrez-Marcos, Daniel Nakhaee-Zadeh Gutierrez, Jan Terje Andersen, Victor Greiff
Published in: Communications Biology, Issue 7, 2024, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-024-06561-3

How to develop a controlled human infection model for Clostridioides difficile

Author(s): Annefleur D.O. Hensen, Maria J.G.T. Vehreschild, Dale N. Gerding, Oleg Krut, Wilbur Chen, Vincent B. Young, Saul Tzipori, Philipp Solbach, Malick Mahdi Gibani, Christopher Chiu, Sigrid C.J. de Keersmaecker, Dileep Dasyam, Sandra Morel, Jeanne-Marie Devaster, Nicoletta Corti, Ed J. Kuijper, Meta Roestenberg, Wiep Klaas Smits
Published in: Clinical Microbiology and Infection, Issue 31, 2025, Page(s) 373-379, ISSN 1198-743X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2024.08.025

High-Performance C++ and Julia solvers in CADET for weakly and strongly coupled continuous chromatography problems

Author(s): Jesper Frandsen, Jan Michael Breuer, Johannes Schmölder, Jens Abildskov, Jakob Kjøbsted Huusom, Krist V. Gernaey, Eric von Lieres
Published in: Computers & Chemical Engineering, Issue 202, 2025, Page(s) 109295, ISSN 0098-1354
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compchemeng.2025.109295

Organ-on-chip models for infectious disease research

Author(s): Raquel Alonso-Roman, Alexander S. Mosig, Marc Thilo Figge, Kai Papenfort, Christian Eggeling, Felix H. Schacher, Bernhard Hube, Mark S. Gresnigt
Published in: Nature Microbiology, Issue 9, 2024, Page(s) 891-904, ISSN 2058-5276
Publisher: Nature Microbiology
DOI: 10.1038/s41564-024-01645-6

Hybrid Optimization Methods for Parameter Estimation of Reactive Transport Systems

Author(s): Marcus Johan Schytt, Halldór Gauti Pétursson, John Bagterp Jørgensen
Published in: IFAC-PapersOnLine, Issue 59, 2025, Page(s) 163-168, ISSN 2405-8963
Publisher: Elsevier BV
DOI: 10.1016/j.ifacol.2025.07.139

Accelerating vaccine manufacturing development through model-based approaches: current advances and future opportunities

Author(s): Elham Ramin, Antonio Gaetano Cardillo, Reinhard Liebers, Johannes Schmölder, Eric von Lieres, Wim Van Molle, Bastian Niebel, Laurent Natalis, Irina Meln, Mónica Perea-Vélez, Didier Clénet, John Bagterp Jørgensen, Bernt Nilsson, Daniel G. Bracewell, Krist V. Gernaey
Published in: Current Opinion in Chemical Engineering, Issue 43, 2024, Page(s) 100998, ISSN 2211-3398
Publisher: Elsevier BV
DOI: 10.1016/j.coche.2023.100998

Regulatory workshop on challenge strain development and GMP manufacture – A stakeholder meeting report

Author(s): Nicoletta Corti, Christopher Chiu, Rebecca J. Cox, Clarisse Demont, Jeanne-Marie Devaster, Othmar G. Engelhardt, Andrew Gorringe, Khaole Hassan, Marcel Hoefnagel, Ingrid Kamerling, Oleg Krut, Chelsea Lane, Reinhard Liebers, Catherine Luke, Wim Van Molle, Sandra Morel, Pieter Neels, Meta Roestenberg, Michelle Rubbrecht, Wiep Klaas Smits, Daniel Stoughton, Kawsar Talaat, Maria J.G.T. Vehreschild, Ad
Published in: Biologicals, Issue 85, 2024, Page(s) 101746, ISSN 1045-1056
Publisher: Academic Press
DOI: 10.1016/j.biologicals.2024.101746

Solving crystallization/precipitation population balance models in CADET, Part II: Size-based Smoluchowski coagulation and fragmentation equations in batch and continuous modes

Author(s): Wendi Zhang, Todd Przybycien, Jan Michael Breuer, Eric von Lieres
Published in: Computers & Chemical Engineering, Issue 192, 2024, Page(s) 108860, ISSN 0098-1354
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compchemeng.2024.108860

Inno4Vac Workshop Report Part 2: RSV‐Controlled Human Infection Model (CHIM) Strain Selection and Immune Assays for RSV CHIM Studies, November 2021, MHRA, UK

Author(s): Joanna Waldock, Rebecca J. Cox, Othmar G. Engelhardt, Stephanie Ascough, Albert Osterhaus, Guus F. Rimmelzwaan, Martin Ludlow, John S. Tregoning, Jacqueline U. McDonald, Ursula J. Buchholz, Rienk E. Jeeninga, Charles. Sande, Christopher Chiu
Published in: Influenza and Other Respiratory Viruses, Issue 18, 2024, ISSN 1750-2640
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/irv.70013

Ethical approval for controlled human infectious model clinical trial protocols – A workshop report

Author(s): Euzebiusz Jamrozik, Katherine Littler, Irina Meln, Wim Van Molle, Sandra Morel, Ole F. Olesen, Michelle Rubbrecht, Shobana Balasingam, Pieter Neels
Published in: Biologicals, Issue 85, 2024, Page(s) 101748, ISSN 1045-1056
Publisher: Academic Press
DOI: 10.1016/j.biologicals.2024.101748

Spatial discontinuous Galerkin spectral element method for a family of chromatography models in CADET

Author(s): Jan Michael Breuer, Samuel Leweke, Johannes Schmölder, Gregor Gassner, Eric von Lieres
Published in: Computers & Chemical Engineering, 2023, Page(s) 108340, ISSN 0098-1354
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compchemeng.2023.108340

Fourth Controlled Human Infection Model (CHIM) meeting, CHIM regulatory issues, May 24, 2023

Author(s): Marco Cavaleri, David Kaslow, Eric Boateng, Wilbur H. Chen, Christopher Chiu, Robert K.M. Choy, Rodrigo Correa-Oliveira, Anna Durbin, Moses Egesa, Malick Gibani, Melissa Kapulu, Melba Katindi, Ally Olotu, Pongphaya Pongsuwan, Michelo Simuyandi, Bruno Speder, Kawsar R. Talaat, Charlie Weller, Bridget Wills, Marc Baay, Shobana Balasingam, Ole F. Olesen, Pieter Neels
Published in: Biologicals, Issue 85, 2024, Page(s) 101745, ISSN 1045-1056
Publisher: Academic Press
DOI: 10.1016/j.biologicals.2024.101745

Immunocompetent PDMS‐Free Organ‐on‐Chip Model of Cervical Cancer Integrating Patient‐Specific Cervical Fibroblasts and Neutrophils

Author(s): Elena Kromidas, Alicia Geier, Adrian Weghofer, Hui‐Yu Liu, Martin Weiss, Peter Loskill
Published in: Advanced Healthcare Materials, Issue 13, 2024, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202302714

Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut–lung axis

Author(s): Hristina Koceva, Mona Amiratashani, Parastoo Akbarimoghaddam, Bianca Hoffmann, Gaukhar Zhurgenbayeva, Mark S. Gresnigt, Vanessa Rossetto Marcelino, Christian Eggeling, Marc Thilo Figge, Maria-João Amorim, Alexander S. Mosig
Published in: Open Biology, Issue 15, 2025, ISSN 2046-2441
Publisher: Royal Society Publishing
DOI: 10.1098/rsob.240231

Other (2)

modsim/CADET: Version 4.4.0

Author(s): Samuel Leweke, Johannes Schmölder, Eric von Lieres, Jayghosh Rao, Jazib Hassan, William Heymann, Jan Breuer, Jonathan Rocher, & Salah Azzouzi
Published in: 2023, ISSN 1082-9873
Publisher: Zenodo
DOI: 10.5281/zenodo.8179016

Advancing In Silico Tools for Vaccine Development and Process Modeling

Author(s): Irina Meln, Gunnveig Grødeland, Daniel G. Bracewell, Meta Roestenberg, Cécile van Els, Kimberly Veenstra and Ole Olesen
Published in: BioProcess International, 2022
Publisher: Informa Connect Limited