Description du projet
Cibler une voie de signalisation du cystéinyl leucotriène pour le traitement des maladies des systèmes oculaires, neuronaux, cardiovasculaires et du cancer
Les cystéinyl leucotriènes (CysLT) sont des lipides bien connus comme jouant le rôle de médiateurs dans le processus de l’inflammation. Des récepteurs de CysLT sont identifiés au niveau des poumons, du rectum, du cœur, du cerveau et des yeux; leurs antagonistes sont utilisés dans le traitement de l’inflammation. Le projet CRYSTAL3, financé par l’UE, créera une équipe pluridisciplinaire, composée de cinq partenaires universitaires et de cinq associés industriels, qui va se concentrer sur une recherche innovante portant sur la signalisation des CysLT dans les pathologies humaines mettant en jeu les systèmes oculaires, neuronaux, cardiovasculaires et impliqués dans le cancer. Dans l’ensemble, les objectifs seront de comprendre les nouveaux mécanismes pathologiques impliquant la signalisation des CysLT, de dévoiler leur potentiel thérapeutique et de développer des produits commerciaux.
Objectif
Cysteinyl leukotrienes (CysLTs) are potent lipid mediators of inflammation. CysLT1 and 2 receptors are widely expressed e.g. lungs, colorectum, heart, brain & eye; and CysLT1 antagonists are prescribed to treat airway inflammation. Excitingly, CysLT signalling was recently discovered to regulate the biology of vascular, neuronal and cancer cells underpinning its untapped therapeutic potential in other diseases. CRYSTAL3 interconnects unique and diverse researchers to create a multidisciplinary team sharing expertise and research capacities. The contribution of CysLT signalling to disease is divulged; its therapeutic potential unlocked and new services & products commercialised. This is delivered by staff exchanges to jointly research Ocular & Central Nervous System (CNS), Cardiovascular system (CV) and Cancer diseases.
The R&I goal of CRYSTAL3 is to reduce human disease burden by enhancing EU capability and knowledge-sharing in research and commercialisation. This is achieved through advanced international co-operation between 5 academic and 5 non-academic partners, in 7 countries. The focus is on innovative research into the CysLT signalling pathway in human diseases related to the Ocular-CNS, & CV systems and Cancer (OCCC).
The 3 overall objectives of CRYSTAL3 are:
A) Combine resources to discover novel pathological mechanisms linking cysteinyl leukotriene signalling to ocular, central nervous system, cardiovascular disease and cancer (OCCC).
B) Unite partner capacities to uncover the therapeutic potential of cysteinyl leukotriene signalling in ocular, central nervous system, cardiovascular disease and cancer (OCCC).
C) Commercialise products and services co-developed within CRYSTAL3
The CRYSTAL3 consortium tackles these challenges by promoting cross-sector, inter-European R&I staff exchanges among participants with expertise in OCCC disease, computational drug discovery, genetic engineering, pre-clinical disease models, marketing and commercialisation.
Champ scientifique
- natural sciencesbiological sciencesneurobiology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesmedical biotechnologygenetic engineering
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health sciencesclinical medicineoncology
Mots‑clés
Programme(s)
Régime de financement
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Coordinateur
4 Dublin
Irlande