Projektbeschreibung
Der Cysteinyl-Leukotrien-Signalweg als Ziel zur Behandlung von Augen-, Nerven-, Herz-Kreislauf- und Krebserkrankungen
Cysteinyl-Leukotriene (CysLTs) sind bekannte Lipidmediatoren bei Entzündungen. CysLT-Rezeptoren finden sich in Lunge, Kolorektum, Herz, Hirn und Auge. Ihre Antagonisten werden zur Entzündungsbehandlung eingesetzt. Das EU-finanzierte Projekt CRYSTAL3 wird ein multidisziplinäres Team aus fünf wissenschaftlichen und fünf industriellen Partnern zusammenstellen, das den Schwerpunkt auf innovative Forschung zur CysLT-Signalgebung bei menschlichen Erkrankungen der Augen, des Nervensystems, des Herz-Kreislauf-Systems sowie bei Krebs legen wird. Als Hauptziele verfolgt das Projekt die Entdeckung neuer pathologischer Mechanismen mit Beteiligung der CysLT-Signalgebung, die Ermittlung ihres therapeutischen Potenzials und die Entwicklung kommerzieller Produkte.
Ziel
Cysteinyl leukotrienes (CysLTs) are potent lipid mediators of inflammation. CysLT1 and 2 receptors are widely expressed e.g. lungs, colorectum, heart, brain & eye; and CysLT1 antagonists are prescribed to treat airway inflammation. Excitingly, CysLT signalling was recently discovered to regulate the biology of vascular, neuronal and cancer cells underpinning its untapped therapeutic potential in other diseases. CRYSTAL3 interconnects unique and diverse researchers to create a multidisciplinary team sharing expertise and research capacities. The contribution of CysLT signalling to disease is divulged; its therapeutic potential unlocked and new services & products commercialised. This is delivered by staff exchanges to jointly research Ocular & Central Nervous System (CNS), Cardiovascular system (CV) and Cancer diseases.
The R&I goal of CRYSTAL3 is to reduce human disease burden by enhancing EU capability and knowledge-sharing in research and commercialisation. This is achieved through advanced international co-operation between 5 academic and 5 non-academic partners, in 7 countries. The focus is on innovative research into the CysLT signalling pathway in human diseases related to the Ocular-CNS, & CV systems and Cancer (OCCC).
The 3 overall objectives of CRYSTAL3 are:
A) Combine resources to discover novel pathological mechanisms linking cysteinyl leukotriene signalling to ocular, central nervous system, cardiovascular disease and cancer (OCCC).
B) Unite partner capacities to uncover the therapeutic potential of cysteinyl leukotriene signalling in ocular, central nervous system, cardiovascular disease and cancer (OCCC).
C) Commercialise products and services co-developed within CRYSTAL3
The CRYSTAL3 consortium tackles these challenges by promoting cross-sector, inter-European R&I staff exchanges among participants with expertise in OCCC disease, computational drug discovery, genetic engineering, pre-clinical disease models, marketing and commercialisation.
Wissenschaftliches Gebiet
- natural sciencesbiological sciencesneurobiology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesmedical biotechnologygenetic engineering
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health sciencesclinical medicineoncology
Schlüsselbegriffe
Programm/Programme
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenKoordinator
4 Dublin
Irland