Project description DEENESFRITPL Learning about real-life handling of protein drugs Innovative protein drugs, genetically engineered versions of human proteins, have the capacity to cure previously incurable diseases. However, they are sensitive due to their complex structure. For instance, they react to shaky transportation or being left beside a sunny window by patients. The EU-funded RealHOPE project will measure real-life events during drug handling by applying smart tag technologies. It will also conduct focus interviews with personnel in hospital pharmacies, clinics and with patients and caregivers to understand current handling practice and what the desired handling instructions and limitations are. These insights will be used to design in use mimicking stability protocols for protein drugs and ultra scaled-down devices for stability assessment. Show the project objective Hide the project objective Objective RealHOPE will create an understanding of the real-life handling of protein drugs in hospital pharmacy, clinics and in the hands of patients by applying smart tag technologies. Different parameters will be logged and combined with protein characterisation at different stages, as well as with information from EFPIA partners on their drugs in use. Statistical evaluation of the data will be used to identify patterns in handling that are linked to protein destabilisation occurrence and type of protein degradation. Focus interviews with personnel in hospital pharmacies, clinics and with patients/care givers will be used to understand current handling practice and what the desired handling instructions and limitations are. These insights will be used to design in-use mimicking stability protocols for the protein drugs in the project. Ultra-scaled-down devices for stability assessment will be designed to be used in early phase for efficient development cost effective and safe future protein therapies. Protocols and devices will be validated towards the collected handling data base. Interventions in hospital pharmacies using e.g. compounding robots will be investigated. Techniques to assess e.g. aggregate formation in the final drug preparation situation will be evaluated together with SMEs producing analytical tools and hospital pharmacists. The collected data and interviews will form the base of development of teaching materials directed towards different target groups: hospital pharmacists, nurses and patients/care givers. App developers will be active in this part to design attractive and efficient apps for teaching and collecting therapy performance data. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacy Keywords In-use protein drug handling printed electronic tags destabilisation triggers protein analytics real-life mimicking stability protocols compounding robot pharmacy QC instrument training modules Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.7. - Innovative Medicines Initiative 2 (IMI2) Topic(s) IMI2-2020-20-06 - Handling of protein drug products and stability concerns Call for proposal H2020-JTI-IMI2-2020-20-two-stage See other projects for this call Funding Scheme RIA - Research and Innovation action Coordinator RISE RESEARCH INSTITUTES OF SWEDEN AB Net EU contribution € 649 778,50 Address Brinellgatan 4 501 15 Boras Sweden See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (26) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CENTRE FOR PROCESS INNOVATION LIMITED LBG United Kingdom Net EU contribution € 456 035,25 Address Wilton centre wilton TS10 4RF Redcar cleveland See on map Region North East (England) Tees Valley and Durham South Teesside Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 LUNDS UNIVERSITET Sweden Net EU contribution € 528 897,50 Address Paradisgatan 5c 22100 Lund See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 26 625,00 UNIVERSITY OF DUNDEE United Kingdom Net EU contribution € 514 968,75 Address Nethergate DD1 4HN Dundee See on map Region Scotland Eastern Scotland Angus and Dundee City Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITY COLLEGE LONDON United Kingdom Net EU contribution € 325 348,75 Address Gower street WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI PADOVA Italy Net EU contribution € 272 500,00 Address Via 8 febbraio 2 35122 Padova See on map Region Nord-Est Veneto Padova Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 REGION UPPSALA Sweden Net EU contribution € 130 445,00 Address Po box 602 751 25 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Spain Net EU contribution € 6 250,00 Address Carrer rossello 149 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. HOSPITAL CLINIC DE BARCELONA Spain Net EU contribution € 33 750,00 Address Calle villarroel 170 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AZIENDA OSPEDALIERA UNIVERSITARIA INTEGRATA 'ISTITUTI OSPITALIERI DI VERONA Italy Net EU contribution € 15 285,00 Address Piazzale aristide stefani 1 37126 Verona See on map Region Nord-Est Veneto Verona Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SOCIETA ITALIANA DI FARMACIA CLINICA E TERAPIA Italy Net EU contribution € 17 250,00 Address Via carlo farini 81 20159 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 REUMATIKERFORBUNDET Sweden Net EU contribution € 12 500,00 Address Halsingegatan 43, 10tr 113 31 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 PROBATION LABS SWEDEN AB Sweden Net EU contribution € 41 347,50 Address Vikbogatan 8 212 32 Malmo See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Södra Sverige Sydsverige Skåne län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ELSA SCIENCE AB Sweden Net EU contribution € 104 500,00 Address Vastmannagatan 4 111 24 Stockholm See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AZIENDA ULSS N3 SERENISSIMA Italy Net EU contribution € 16 250,00 Address Via don tosatto 147 30174 Venezia mestre See on map Region Nord-Est Veneto Venezia Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 PLURIMA SPA Italy Net EU contribution € 14 877,50 Address Piazza santo stefano 6 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ABBVIE INC United States Net EU contribution € 0,00 Address North waukegan road 1 60064 North chicago il See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 454 000,00 ASTRAZENECA AB Sweden Net EU contribution € 0,00 Address Vastra maelarhamnen 151 85 Sodertaelje See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 350 000,00 BOEHRINGER INGELHEIM INTERNATIONALGMBH Germany Net EU contribution € 0,00 Address Binger strasse 55218 Ingelheim See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz-Bingen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 230 000,00 LONZA AG Switzerland Net EU contribution € 0,00 Address Muenchensteinerstrasse 38 4002 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 800 000,00 MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN Germany Net EU contribution € 0,00 Address Frankfurter strasse 250 64293 Darmstadt See on map Region Hessen Darmstadt Darmstadt, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 200 000,00 PFIZER LIMITED United Kingdom Net EU contribution € 0,00 Address Ramsgate road CT13 9NJ Sandwich See on map Region South East (England) Kent East Kent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 250 000,00 F. HOFFMANN-LA ROCHE AG Switzerland Net EU contribution € 0,00 Address Grenzacherstrasse 124 4070 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 240 000,00 SANOFI-AVENTIS DEUTSCHLAND GMBH Germany Net EU contribution € 0,00 Address Bruningstrasse 50 65929 Frankfurt am main See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 1 360 000,00 TEVA PHARMACEUTICAL INDUSTRIES LIMITED Israel Net EU contribution € 0,00 Address 5 basel st 49131 Petach tivka See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 75 000,00 ICU MEDICAL BV Netherlands Net EU contribution € 0,00 Address Hofspoor 3 3994 VZ Houten See on map Region West-Nederland Utrecht Utrecht Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 2 000,00 ISTITUTO ONCOLOGICO VENETO Italy Net EU contribution € 0,00 Address Via gattamelata 64 35128 Padova See on map Region Nord-Est Veneto Padova Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 5 000,00
