Descrizione del progetto
I materiali naturali aiutano i tessuti a creare vasi sanguigni naturali nelle applicazioni di ingegneria tissutale
La rigenerazione dei tessuti umani per scopi terapeutici è una strategia di trattamento che ha ricevuto molta attenzione grazie ai suoi promettenti risultati. I partner del progetto SHIFT, finanziato dall’UE, hanno progettato diversi dispositivi con polimeri a base biologica in grado di promuovere la rigenerazione di pelle, ossa e cartilagini durante l’attuazione di MSCA-RISE REMIX (2017-2021). Con SHIFT, il consorzio mira a scalarli fino a una fase in cui possano essere portati a studi clinici attraverso il miglioramento della capacità angiogenetica (fondamentale per garantire la rigenerazione dei tessuti), l’ottimizzazione del processo considerando la scalabilità, la produzione di biopolimeri di grado medico e la previsione dei costi. Nel farlo, SHIFT applicherà i principi della chimica verde per ridurre le esternalità ambientali negative della ricerca.
Obiettivo
Shaping Innovative Products for Sustainable Tissue Engineering Strategies - SHIFT is the follow up of MSCA-RISE REMIX (GA 778078). While REMIX researched and confirmed the potential of natural origin material such as silk proteins, collagen, keratin and marine organism-derived polymers for use in Tissue Engineering and Regenerative Medicine, SHIFT aims to take the research a step forward and design innovative natural-based, scalable constructs that enhance angiogenesis for the treatment of widespread chronic pathologies, such as large defect in bone and cartilage and the treatment of chronic wounds (ex. diabetic ulcer). Prototypes will be fabricated considering scalability, costs, regulatory issues.
Multiple strategies will be used to achieve this aim:
- pre-assessment of the regulative framework for TERM products and close collaboration with the industry;
- fabrication in accordance with current GMP and ISO quality management Systems-requirements
- standardization of the protocols for purification of raw materials from the waste of textile and food industry for the production of these prototypes, using medical-grade, commercially-available raw materials as benchmark. This may lead to the opening of a new opportunity for re-using industrial waste which is currently disposed of.
- application of the principles of Green Chemistry to reduce the environmental impact of the research and production of the prototypes.
An extensive training program will be offered to ESRs to set the best conditions for successful performance. The program will be offered through summer schools and online seminars and will cover a variety of topics related to TERM, technologies, regulations for product development. A special highlight will be devoted to product-development, spin-off, venture capitals, to provide junior researchers with knowledge and skills that may allow them to become profiles capable to successfully transfer ideas and innovations from academia to the industry.
Campo scientifico
Parole chiave
Programma(i)
Meccanismo di finanziamento
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Coordinatore
38122 Trento
Italia