Descripción del proyecto
Los materiales naturales ayudan a los tejidos a crear vasos sanguíneos naturales en aplicaciones de ingeniería tisular
La regeneración de tejidos humanos con fines terapéuticos es una estrategia de tratamiento que ha recibido mucha atención por sus resultados prometedores. Los socios del proyecto SHIFT, financiado con fondos europeos, han diseñado varios dispositivos con polímeros de origen biológico capaces de estimular la regeneración de la piel, el hueso y el cartílago durante el proyecto REMIX, ejecutado en el marco de la acción Marie Skłodowska-Curie RISE (2017-2021). Con SHIFT, el consorcio pretende llegar a una fase en la que puedan llevarse a ensayos clínicos mediante la mejora de la capacidad angiogénica (fundamental para garantizar la regeneración de los tejidos), la optimización del proceso teniendo en cuenta la escalabilidad, la producción de biopolímeros de calidad médica y la previsión de costes. De esta forma, SHIFT aplicará los principios de la química ecológica para reducir las externalidades ambientales negativas de la investigación.
Objetivo
Shaping Innovative Products for Sustainable Tissue Engineering Strategies - SHIFT is the follow up of MSCA-RISE REMIX (GA 778078). While REMIX researched and confirmed the potential of natural origin material such as silk proteins, collagen, keratin and marine organism-derived polymers for use in Tissue Engineering and Regenerative Medicine, SHIFT aims to take the research a step forward and design innovative natural-based, scalable constructs that enhance angiogenesis for the treatment of widespread chronic pathologies, such as large defect in bone and cartilage and the treatment of chronic wounds (ex. diabetic ulcer). Prototypes will be fabricated considering scalability, costs, regulatory issues.
Multiple strategies will be used to achieve this aim:
- pre-assessment of the regulative framework for TERM products and close collaboration with the industry;
- fabrication in accordance with current GMP and ISO quality management Systems-requirements
- standardization of the protocols for purification of raw materials from the waste of textile and food industry for the production of these prototypes, using medical-grade, commercially-available raw materials as benchmark. This may lead to the opening of a new opportunity for re-using industrial waste which is currently disposed of.
- application of the principles of Green Chemistry to reduce the environmental impact of the research and production of the prototypes.
An extensive training program will be offered to ESRs to set the best conditions for successful performance. The program will be offered through summer schools and online seminars and will cover a variety of topics related to TERM, technologies, regulations for product development. A special highlight will be devoted to product-development, spin-off, venture capitals, to provide junior researchers with knowledge and skills that may allow them to become profiles capable to successfully transfer ideas and innovations from academia to the industry.
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MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Coordinador
38122 Trento
Italia