Project description DEENESFRITPL Portable device for COVID-19 real-time detection As the world is bracing for the second wave of the rapidly spreading coronavirus, accurate diagnostic tools have emerged as a global priority. Together with isolation and tracking, the large-scale testing of citizens is proving to be most effective in controlling COVID-19. However, adequate, robust testing solutions are necessary to achieve fast results in protecting populations. For this reason, the EU-funded IRIS-COV project is proposing a solution based on a patented portable device with isothermal LAMP amplification and real-time, quantitative, colourimetric detection that has proven 97.4 % sensitive and 100 % specific for SARS-CoV-2 in samples. The project will validate and certify the portable device for COVID-19 and flu detection directly in crude samples and at the point of care, aiming towards its global uptake. Show the project objective Hide the project objective Objective The current pandemic of the coronavirus, reported first on 31st December 2019 in China, has produced a global alert of unprecedented nature. From the beginning, immediate actions have been put in place by all relevant stakeholders, i.e. local health departments, governments, pharmaceutical companies, global organisations etc., to address the problem as quickly as possible and control the spread of the disease. Large scale testing of symptomatic and asymptomatic patients/citizens has been one of the most effective measures taken by several countries, combined with isolation and tracking. Today, after six months from the outbreak, the deaths continue to rise with over 200 affected countries. Fear of a new wave of the pandemic together with the ongoing cases worldwide make the need for developing rapid and accurate diagnostic tools for COVID-19 a global priority, as declared by the WHO. The current consortium aims to join forces in the battle against the coronavirus by producing mature and robust solutions with immediate impact. The proposal is built around the implementation of an existing and patented device and methodology based on isothermal LAMP amplification and real time quantitative colorimetric detection. This mature methodology, currently of a technology readiness level of 7, has already been proven to be able to detect SARS-CoV-2 in patients’ samples with 97.4% sensitivity and 100% specificity. The main objectives of this proposal are thus the immediate deployment of the device following clinical validation and fast track certification. Arrangements for the large-scale production of the device and reagents will take place in parallel, followed by the provision of a full medical certification for COVID-19 and flu detection directly in crude samples and at the point-of-care. Global uptake of the two certified products together with global sharing of the project results are important deliverables of the proposal for the current and future epidemics. Fields of science medical and health scienceshealth sciencespublic healthepidemiologypandemicsmedical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses Keywords Molecular diagnostics LAMP point-of-care portable device 3D-printing Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme Topic(s) SC1-PHE-CORONAVIRUS-2020-2B - Medical technologies, Digital tools and Artificial Intelligence (AI) analytics to improve surveillance and care at high Technology Readiness Levels (TRL) Call for proposal H2020-SC1-PHE-CORONAVIRUS-2020-2 See other projects for this call Sub call H2020-SC1-PHE-CORONAVIRUS-2020-2-CNECT Funding Scheme IA - Innovation action Coordinator IDRYMA TECHNOLOGIAS KAI EREVNAS Net EU contribution € 252 000,00 Address N plastira str 100 70013 Irakleio Greece See on map Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST United Kingdom Net EU contribution € 269 626,25 Address Euston road 250 NW1 2PG London See on map Region London Inner London — West Camden and City of London Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Net EU contribution € 146 000,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BIOPIX DNA TECHNOLOGY IKE Greece Net EU contribution € 520 625,00 Address N. plastira 100 700 13 Heraklion See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 223 125,00 UNIVERSITE LIBRE DE BRUXELLES Belgium Net EU contribution € 120 600,00 Address Avenue franklin roosevelt 50 1050 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ENZYQUEST PRIVATE COMPANY Greece Net EU contribution € 285 687,50 Address Science and technology park of crete nikolaou plastira 100 vassilika vouton 70013 Heraklion See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 122 437,50 PKNM SOLUTIONS SARL Switzerland Net EU contribution € 503 776,88 Address Chemin des vignes 2 1114 Colombier See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 215 904,37 KIARA HEALTH (PTY) LTD South Africa Net EU contribution € 286 562,50 Address 89 elevation avenue 1683 Randjesfontein See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 122 812,50
