Improved therapies for soil-transmitted helminthiases: exploring pharmacomicrobiomics, novel drugs and microfluidic assay platforms

Project Information

DRUGSBUGS

Grant agreement ID: 101019223

DOI

10.3030/101019223

EC signature date 14 July 2021

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 470 621,00

EU contribution

€ 2 470 621,00

Coordinated by

SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan (DMP)

Data Management Plan

Publications

Peer reviewed articles (18)

Schistosomiasis: cercarial finding and recognizing of human hosts as a prerequisite of invasion

Author(s): Ursula Panzner, Jürg Utzinger, Jennifer Keiser
Published in: Clinical Microbiology Reviews, Issue 38, 2025, ISSN 0893-8512
Publisher: American Society for Microbiology
DOI: 10.1128/cmr.00196-24

Emodepside for <i>Trichuris trichiura</i> and Hookworm Infection

Author(s): Emmanuel C. Mrimi, Sophie Welsche, Said M. Ali, Jan Hattendorf, Jennifer Keiser
Published in: New England Journal of Medicine, Issue 388, 2024, Page(s) 1863-1875, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmoa2212825

Combined high-quality metagenomics reveals off-target effects of albendazole, ivermectin-albendazole and moxidectin-albendazole on the human gut bacteria

Author(s): Julian Dommann, Viviane P. Sprecher, Christian Beisel, Daniel Ballmer, Eveline Hürlimann, Jean T. Coulibaly, Jennifer Keiser, Pierre H. H. Schneeberger
Published in: npj Biofilms and Microbiomes, 2026, ISSN 2055-5008
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41522-026-01018-3

Implementation of real-time PCR assays for diagnosing intestinal protozoa infections

Author(s): Christian N. Lotz, Pierre H. H. Schneeberger, Maura Concu, Said M. Ali, Emmanuel C. Mrimi, Jennifer Keiser
Published in: Parasitology Research, Issue 124, 2025, ISSN 0932-0113
Publisher: Springer Verlag
DOI: 10.1007/s00436-025-08483-3

Robenidine derivatives as potential antischistosomal drug candidates

Author(s): Christian N. Lotz, Alina Krollenbrock, Lea Imhof, Michael Riscoe, Jennifer Keiser
Published in: International Journal for Parasitology: Drugs and Drug Resistance, Issue 25, 2024, Page(s) 100546, ISSN 2211-3207
Publisher: Elsevier BV
DOI: 10.1016/j.ijpddr.2024.100546

Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases

Author(s): Pierre H. H. Schneeberger, Morgan Gueuning, Sophie Welsche, Eveline Hürlimann, Julian Dommann, Cécile Häberli, Jürg E. Frey, Somphou Sayasone, Jennifer Keiser
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28658-1

Widespread Trichuris incognita reveals hidden diversity and reshapes understanding of human whipworm infections

Author(s): Nurudeen Rahman, Max A. Bär, Julian Dommann, Eveline Hürlimann, Jean T. Coulibaly, Said Ali, Somphou Sayasone, Prudence Beinamaryo, Jennifer Keiser, Pierre H. H. Schneeberger
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-64516-6

Efficacy and safety of emodepside compared with albendazole in adolescents and adults with hookworm infection in Pemba Island, Tanzania: a double-blind, superiority, phase 2b, randomised controlled trial

Author(s): Lyndsay Taylor, Ahmada Ali Ahmada, Msanif Said Ali, Said Mohammed Ali, Jan Hattendorf, Ibrahim Said Mohammed, Jennifer Keiser
Published in: The Lancet, Issue 404, 2024, Page(s) 683-691, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(24)01403-x

Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized controlled trials

Author(s): Christian N. Lotz, Emmanuel C. Mrimi, Pierre H. H. Schneeberger, Said M. Ali, Jan Hattendorf, Jennifer Keiser
Published in: PLOS Neglected Tropical Diseases, Issue 19, 2025, Page(s) e0012872, ISSN 1935-2735
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pntd.0012872

Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit <i>Schistosoma mansoni</i> Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages

Author(s): Roberto Gimmelli, Giuliana Papoff, Emanuele Fabbrizi, Michela Guida, Cristiana Lalli, Fulvio Saccoccia, Cécile Häberli, Jennifer Keiser, Daria Monaldi, Manfred Jung, Christophe Romier, Dante Rotili, Antonello Mai, Giovina Ruberti
Published in: ACS Infectious Diseases, Issue 11, 2025, Page(s) 3115-3127, ISSN 2373-8227
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsinfecdis.5c00515

Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of <i>Schistosoma mansoni</i>

Author(s): Emanuele Fabbrizi, Gebremedhin Solomon Hailu, A. Ganesan, Rossella Fioravanti, Clemens Zwergel, Chiara Lambona, Sergio Valente, Giulia Fianco, Angela Iuzzolino, Daniela Trisciuoglio, Jonatan Caroli, Andrea Mattevi, Cécile Häberli, Jennifer Keiser, Dante Rotili, Antonello Mai
Published in: ACS Infectious Diseases, Issue 11, 2025, Page(s) 2178-2189, ISSN 2373-8227
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsinfecdis.5c00224

Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns

Author(s): Pierre H. H. Schneeberger, Julian Dommann, Nurudeen Rahman, Eveline Hürlimann, Somphou Sayasone, Said Ali, Jean Tenena Coulibaly, Jennifer Keiser
Published in: npj Biofilms and Microbiomes, Issue 12, 2026, ISSN 2055-5008
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41522-026-00911-1

Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, In vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation

Author(s): Godwin A. Dziwornu, Henrietta Dede Attram, Cécile Haeberli, Keabetswe Masike, Mathew Njoroge, Jennifer Keiser
Published in: European Journal of Medicinal Chemistry, Issue 284, 2025, Page(s) 117186, ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/j.ejmech.2024.117186

Present drugs and future perspectives in treating soil-transmitted helminthiasis

Author(s): Jennifer Keiser
Published in: Frontiers in Tropical Diseases, Issue 4, 2023, ISSN 2673-7515
Publisher: Frontiers Media SA
DOI: 10.3389/fitd.2023.1282725

A novel barcoded nanopore sequencing workflow of high-quality, full-length bacterial 16S amplicons for taxonomic annotation of bacterial isolates and complex microbial communities

Author(s): Julian Dommann, Jakob Kerbl-Knapp, Diana Albertos Torres, Adrian Egli, Jennifer Keiser, Pierre H. H. Schneeberger
Published in: mSystems, Issue 9, 2024, ISSN 2379-5077
Publisher: American Society for Microbiology
DOI: 10.1128/msystems.00859-24

Efficacy and safety of ascending doses of emodepside in comparison with ivermectin in adults infected with Strongyloides stercoralis in Laos: a phase 2a, dose-ranging, randomised, parallel-group, placebo-controlled, single-blind clinical trial

Author(s): Lyndsay Taylor, Sysouphanh Many, Hannah Jeanguenat, Jan Hattendorf, Somphou Sayasone, Jennifer Keiser
Published in: The Lancet Infectious Diseases, Issue 25, 2025, Page(s) 1254-1264, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(25)00255-5

Exposure of gut bacterial isolates to the anthelminthic drugs, ivermectin and moxidectin, leads to antibiotic-like phenotypes of growth inhibition and adaptation

Author(s): Julian Dommann, Jennifer Keiser, Julian Garneau, Alison Gandelin, Carlo Casanova, Peter M. Keller, Somphou Sayasone, Pascale Vonaesch, Pierre H. H. Schneeberger
Published in: Communications Biology, Issue 7, 2024, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-07135-z

Characterisation of Trichuris incognita n sp in Côte d’Ivoire: a morphological, genomic, and genome-wide association with drug sensitivity study

Author(s): Max Alexander Bär, Nadège Akissi Kouamé, Sadikou Touré, Jean Tenena Coulibaly, Pierre Henri Hermann Schneeberger, Jennifer Keiser
Published in: The Lancet Microbe, Issue 7, 2026, Page(s) 101264, ISSN 2666-5247
Publisher: Elsevier BV
DOI: 10.1016/j.lanmic.2025.101264