Improved therapies for soil-transmitted helminthiases: exploring pharmacomicrobiomics, novel drugs and microfluidic assay platforms

Informazioni relative al progetto

DRUGSBUGS

ID dell’accordo di sovvenzione: 101019223

DOI

10.3030/101019223

Data della firma CE 14 Luglio 2021

Data di avvio 1 Gennaio 2022

Data di completamento 31 Dicembre 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 470 621,00

Contributo UE

€ 2 470 621,00

Coordinato da

SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan (DMP)

Data Management Plan

Pubblicazioni

Peer reviewed articles (18)

Schistosomiasis: cercarial finding and recognizing of human hosts as a prerequisite of invasion

Autori: Ursula Panzner, Jürg Utzinger, Jennifer Keiser
Pubblicato in: Clinical Microbiology Reviews, Numero 38, 2025, ISSN 0893-8512
Editore: American Society for Microbiology
DOI: 10.1128/cmr.00196-24

Emodepside for <i>Trichuris trichiura</i> and Hookworm Infection

Autori: Emmanuel C. Mrimi, Sophie Welsche, Said M. Ali, Jan Hattendorf, Jennifer Keiser
Pubblicato in: New England Journal of Medicine, Numero 388, 2024, Pagina/e 1863-1875, ISSN 0028-4793
Editore: Massachusetts Medical Society
DOI: 10.1056/nejmoa2212825

Combined high-quality metagenomics reveals off-target effects of albendazole, ivermectin-albendazole and moxidectin-albendazole on the human gut bacteria

Autori: Julian Dommann, Viviane P. Sprecher, Christian Beisel, Daniel Ballmer, Eveline Hürlimann, Jean T. Coulibaly, Jennifer Keiser, Pierre H. H. Schneeberger
Pubblicato in: npj Biofilms and Microbiomes, 2026, ISSN 2055-5008
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41522-026-01018-3

Implementation of real-time PCR assays for diagnosing intestinal protozoa infections

Autori: Christian N. Lotz, Pierre H. H. Schneeberger, Maura Concu, Said M. Ali, Emmanuel C. Mrimi, Jennifer Keiser
Pubblicato in: Parasitology Research, Numero 124, 2025, ISSN 0932-0113
Editore: Springer Verlag
DOI: 10.1007/s00436-025-08483-3

Robenidine derivatives as potential antischistosomal drug candidates

Autori: Christian N. Lotz, Alina Krollenbrock, Lea Imhof, Michael Riscoe, Jennifer Keiser
Pubblicato in: International Journal for Parasitology: Drugs and Drug Resistance, Numero 25, 2024, Pagina/e 100546, ISSN 2211-3207
Editore: Elsevier BV
DOI: 10.1016/j.ijpddr.2024.100546

Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases

Autori: Pierre H. H. Schneeberger, Morgan Gueuning, Sophie Welsche, Eveline Hürlimann, Julian Dommann, Cécile Häberli, Jürg E. Frey, Somphou Sayasone, Jennifer Keiser
Pubblicato in: Nature Communications, Numero 13, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28658-1

Widespread Trichuris incognita reveals hidden diversity and reshapes understanding of human whipworm infections

Autori: Nurudeen Rahman, Max A. Bär, Julian Dommann, Eveline Hürlimann, Jean T. Coulibaly, Said Ali, Somphou Sayasone, Prudence Beinamaryo, Jennifer Keiser, Pierre H. H. Schneeberger
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-64516-6

Efficacy and safety of emodepside compared with albendazole in adolescents and adults with hookworm infection in Pemba Island, Tanzania: a double-blind, superiority, phase 2b, randomised controlled trial

Autori: Lyndsay Taylor, Ahmada Ali Ahmada, Msanif Said Ali, Said Mohammed Ali, Jan Hattendorf, Ibrahim Said Mohammed, Jennifer Keiser
Pubblicato in: The Lancet, Numero 404, 2024, Pagina/e 683-691, ISSN 0140-6736
Editore: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(24)01403-x

Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized controlled trials

Autori: Christian N. Lotz, Emmanuel C. Mrimi, Pierre H. H. Schneeberger, Said M. Ali, Jan Hattendorf, Jennifer Keiser
Pubblicato in: PLOS Neglected Tropical Diseases, Numero 19, 2025, Pagina/e e0012872, ISSN 1935-2735
Editore: Public Library of Science (PLoS)
DOI: 10.1371/journal.pntd.0012872

Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit <i>Schistosoma mansoni</i> Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages

Autori: Roberto Gimmelli, Giuliana Papoff, Emanuele Fabbrizi, Michela Guida, Cristiana Lalli, Fulvio Saccoccia, Cécile Häberli, Jennifer Keiser, Daria Monaldi, Manfred Jung, Christophe Romier, Dante Rotili, Antonello Mai, Giovina Ruberti
Pubblicato in: ACS Infectious Diseases, Numero 11, 2025, Pagina/e 3115-3127, ISSN 2373-8227
Editore: American Chemical Society (ACS)
DOI: 10.1021/acsinfecdis.5c00515

Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of <i>Schistosoma mansoni</i>

Autori: Emanuele Fabbrizi, Gebremedhin Solomon Hailu, A. Ganesan, Rossella Fioravanti, Clemens Zwergel, Chiara Lambona, Sergio Valente, Giulia Fianco, Angela Iuzzolino, Daniela Trisciuoglio, Jonatan Caroli, Andrea Mattevi, Cécile Häberli, Jennifer Keiser, Dante Rotili, Antonello Mai
Pubblicato in: ACS Infectious Diseases, Numero 11, 2025, Pagina/e 2178-2189, ISSN 2373-8227
Editore: American Chemical Society (ACS)
DOI: 10.1021/acsinfecdis.5c00224

Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns

Autori: Pierre H. H. Schneeberger, Julian Dommann, Nurudeen Rahman, Eveline Hürlimann, Somphou Sayasone, Said Ali, Jean Tenena Coulibaly, Jennifer Keiser
Pubblicato in: npj Biofilms and Microbiomes, Numero 12, 2026, ISSN 2055-5008
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41522-026-00911-1

Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, In vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation

Autori: Godwin A. Dziwornu, Henrietta Dede Attram, Cécile Haeberli, Keabetswe Masike, Mathew Njoroge, Jennifer Keiser
Pubblicato in: European Journal of Medicinal Chemistry, Numero 284, 2025, Pagina/e 117186, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2024.117186

Present drugs and future perspectives in treating soil-transmitted helminthiasis

Autori: Jennifer Keiser
Pubblicato in: Frontiers in Tropical Diseases, Numero 4, 2023, ISSN 2673-7515
Editore: Frontiers Media SA
DOI: 10.3389/fitd.2023.1282725

A novel barcoded nanopore sequencing workflow of high-quality, full-length bacterial 16S amplicons for taxonomic annotation of bacterial isolates and complex microbial communities

Autori: Julian Dommann, Jakob Kerbl-Knapp, Diana Albertos Torres, Adrian Egli, Jennifer Keiser, Pierre H. H. Schneeberger
Pubblicato in: mSystems, Numero 9, 2024, ISSN 2379-5077
Editore: American Society for Microbiology
DOI: 10.1128/msystems.00859-24

Efficacy and safety of ascending doses of emodepside in comparison with ivermectin in adults infected with Strongyloides stercoralis in Laos: a phase 2a, dose-ranging, randomised, parallel-group, placebo-controlled, single-blind clinical trial

Autori: Lyndsay Taylor, Sysouphanh Many, Hannah Jeanguenat, Jan Hattendorf, Somphou Sayasone, Jennifer Keiser
Pubblicato in: The Lancet Infectious Diseases, Numero 25, 2025, Pagina/e 1254-1264, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(25)00255-5

Exposure of gut bacterial isolates to the anthelminthic drugs, ivermectin and moxidectin, leads to antibiotic-like phenotypes of growth inhibition and adaptation

Autori: Julian Dommann, Jennifer Keiser, Julian Garneau, Alison Gandelin, Carlo Casanova, Peter M. Keller, Somphou Sayasone, Pascale Vonaesch, Pierre H. H. Schneeberger
Pubblicato in: Communications Biology, Numero 7, 2024, ISSN 2399-3642
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-07135-z

Characterisation of Trichuris incognita n sp in Côte d’Ivoire: a morphological, genomic, and genome-wide association with drug sensitivity study

Autori: Max Alexander Bär, Nadège Akissi Kouamé, Sadikou Touré, Jean Tenena Coulibaly, Pierre Henri Hermann Schneeberger, Jennifer Keiser
Pubblicato in: The Lancet Microbe, Numero 7, 2026, Pagina/e 101264, ISSN 2666-5247
Editore: Elsevier BV
DOI: 10.1016/j.lanmic.2025.101264