Improved therapies for soil-transmitted helminthiases: exploring pharmacomicrobiomics, novel drugs and microfluidic assay platforms

Información del proyecto

DRUGSBUGS

Identificador del acuerdo de subvención: 101019223

DOI

10.3030/101019223

Fecha de la firma de la CE 14 Julio 2021

Fecha de inicio 1 Enero 2022

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 470 621,00

Aportación de la UE

€ 2 470 621,00

Coordinado por

SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan (DMP)

Data Management Plan

Publicaciones

Peer reviewed articles (18)

Schistosomiasis: cercarial finding and recognizing of human hosts as a prerequisite of invasion

Autores: Ursula Panzner, Jürg Utzinger, Jennifer Keiser
Publicado en: Clinical Microbiology Reviews, Edición 38, 2025, ISSN 0893-8512
Editor: American Society for Microbiology
DOI: 10.1128/cmr.00196-24

Emodepside for <i>Trichuris trichiura</i> and Hookworm Infection

Autores: Emmanuel C. Mrimi, Sophie Welsche, Said M. Ali, Jan Hattendorf, Jennifer Keiser
Publicado en: New England Journal of Medicine, Edición 388, 2024, Página(s) 1863-1875, ISSN 0028-4793
Editor: Massachusetts Medical Society
DOI: 10.1056/nejmoa2212825

Combined high-quality metagenomics reveals off-target effects of albendazole, ivermectin-albendazole and moxidectin-albendazole on the human gut bacteria

Autores: Julian Dommann, Viviane P. Sprecher, Christian Beisel, Daniel Ballmer, Eveline Hürlimann, Jean T. Coulibaly, Jennifer Keiser, Pierre H. H. Schneeberger
Publicado en: npj Biofilms and Microbiomes, 2026, ISSN 2055-5008
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41522-026-01018-3

Implementation of real-time PCR assays for diagnosing intestinal protozoa infections

Autores: Christian N. Lotz, Pierre H. H. Schneeberger, Maura Concu, Said M. Ali, Emmanuel C. Mrimi, Jennifer Keiser
Publicado en: Parasitology Research, Edición 124, 2025, ISSN 0932-0113
Editor: Springer Verlag
DOI: 10.1007/s00436-025-08483-3

Robenidine derivatives as potential antischistosomal drug candidates

Autores: Christian N. Lotz, Alina Krollenbrock, Lea Imhof, Michael Riscoe, Jennifer Keiser
Publicado en: International Journal for Parasitology: Drugs and Drug Resistance, Edición 25, 2024, Página(s) 100546, ISSN 2211-3207
Editor: Elsevier BV
DOI: 10.1016/j.ijpddr.2024.100546

Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases

Autores: Pierre H. H. Schneeberger, Morgan Gueuning, Sophie Welsche, Eveline Hürlimann, Julian Dommann, Cécile Häberli, Jürg E. Frey, Somphou Sayasone, Jennifer Keiser
Publicado en: Nature Communications, Edición 13, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-28658-1

Widespread Trichuris incognita reveals hidden diversity and reshapes understanding of human whipworm infections

Autores: Nurudeen Rahman, Max A. Bär, Julian Dommann, Eveline Hürlimann, Jean T. Coulibaly, Said Ali, Somphou Sayasone, Prudence Beinamaryo, Jennifer Keiser, Pierre H. H. Schneeberger
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-64516-6

Efficacy and safety of emodepside compared with albendazole in adolescents and adults with hookworm infection in Pemba Island, Tanzania: a double-blind, superiority, phase 2b, randomised controlled trial

Autores: Lyndsay Taylor, Ahmada Ali Ahmada, Msanif Said Ali, Said Mohammed Ali, Jan Hattendorf, Ibrahim Said Mohammed, Jennifer Keiser
Publicado en: The Lancet, Edición 404, 2024, Página(s) 683-691, ISSN 0140-6736
Editor: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(24)01403-x

Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized controlled trials

Autores: Christian N. Lotz, Emmanuel C. Mrimi, Pierre H. H. Schneeberger, Said M. Ali, Jan Hattendorf, Jennifer Keiser
Publicado en: PLOS Neglected Tropical Diseases, Edición 19, 2025, Página(s) e0012872, ISSN 1935-2735
Editor: Public Library of Science (PLoS)
DOI: 10.1371/journal.pntd.0012872

Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit <i>Schistosoma mansoni</i> Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages

Autores: Roberto Gimmelli, Giuliana Papoff, Emanuele Fabbrizi, Michela Guida, Cristiana Lalli, Fulvio Saccoccia, Cécile Häberli, Jennifer Keiser, Daria Monaldi, Manfred Jung, Christophe Romier, Dante Rotili, Antonello Mai, Giovina Ruberti
Publicado en: ACS Infectious Diseases, Edición 11, 2025, Página(s) 3115-3127, ISSN 2373-8227
Editor: American Chemical Society (ACS)
DOI: 10.1021/acsinfecdis.5c00515

Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of <i>Schistosoma mansoni</i>

Autores: Emanuele Fabbrizi, Gebremedhin Solomon Hailu, A. Ganesan, Rossella Fioravanti, Clemens Zwergel, Chiara Lambona, Sergio Valente, Giulia Fianco, Angela Iuzzolino, Daniela Trisciuoglio, Jonatan Caroli, Andrea Mattevi, Cécile Häberli, Jennifer Keiser, Dante Rotili, Antonello Mai
Publicado en: ACS Infectious Diseases, Edición 11, 2025, Página(s) 2178-2189, ISSN 2373-8227
Editor: American Chemical Society (ACS)
DOI: 10.1021/acsinfecdis.5c00224

Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns

Autores: Pierre H. H. Schneeberger, Julian Dommann, Nurudeen Rahman, Eveline Hürlimann, Somphou Sayasone, Said Ali, Jean Tenena Coulibaly, Jennifer Keiser
Publicado en: npj Biofilms and Microbiomes, Edición 12, 2026, ISSN 2055-5008
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41522-026-00911-1

Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, In vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation

Autores: Godwin A. Dziwornu, Henrietta Dede Attram, Cécile Haeberli, Keabetswe Masike, Mathew Njoroge, Jennifer Keiser
Publicado en: European Journal of Medicinal Chemistry, Edición 284, 2025, Página(s) 117186, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2024.117186

Present drugs and future perspectives in treating soil-transmitted helminthiasis

Autores: Jennifer Keiser
Publicado en: Frontiers in Tropical Diseases, Edición 4, 2023, ISSN 2673-7515
Editor: Frontiers Media SA
DOI: 10.3389/fitd.2023.1282725

A novel barcoded nanopore sequencing workflow of high-quality, full-length bacterial 16S amplicons for taxonomic annotation of bacterial isolates and complex microbial communities

Autores: Julian Dommann, Jakob Kerbl-Knapp, Diana Albertos Torres, Adrian Egli, Jennifer Keiser, Pierre H. H. Schneeberger
Publicado en: mSystems, Edición 9, 2024, ISSN 2379-5077
Editor: American Society for Microbiology
DOI: 10.1128/msystems.00859-24

Efficacy and safety of ascending doses of emodepside in comparison with ivermectin in adults infected with Strongyloides stercoralis in Laos: a phase 2a, dose-ranging, randomised, parallel-group, placebo-controlled, single-blind clinical trial

Autores: Lyndsay Taylor, Sysouphanh Many, Hannah Jeanguenat, Jan Hattendorf, Somphou Sayasone, Jennifer Keiser
Publicado en: The Lancet Infectious Diseases, Edición 25, 2025, Página(s) 1254-1264, ISSN 1473-3099
Editor: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(25)00255-5

Exposure of gut bacterial isolates to the anthelminthic drugs, ivermectin and moxidectin, leads to antibiotic-like phenotypes of growth inhibition and adaptation

Autores: Julian Dommann, Jennifer Keiser, Julian Garneau, Alison Gandelin, Carlo Casanova, Peter M. Keller, Somphou Sayasone, Pascale Vonaesch, Pierre H. H. Schneeberger
Publicado en: Communications Biology, Edición 7, 2024, ISSN 2399-3642
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-07135-z

Characterisation of Trichuris incognita n sp in Côte d’Ivoire: a morphological, genomic, and genome-wide association with drug sensitivity study

Autores: Max Alexander Bär, Nadège Akissi Kouamé, Sadikou Touré, Jean Tenena Coulibaly, Pierre Henri Hermann Schneeberger, Jennifer Keiser
Publicado en: The Lancet Microbe, Edición 7, 2026, Página(s) 101264, ISSN 2666-5247
Editor: Elsevier BV
DOI: 10.1016/j.lanmic.2025.101264