Improved therapies for soil-transmitted helminthiases: exploring pharmacomicrobiomics, novel drugs and microfluidic assay platforms

Informacje na temat projektu

DRUGSBUGS

Identyfikator umowy o grant: 101019223

DOI

10.3030/101019223

Data podpisania przez KE 14 Lipca 2021

Data rozpoczęcia 1 Stycznia 2022

Data zakończenia 31 Grudnia 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 470 621,00

Wkład UE

€ 2 470 621,00

Koordynowany przez

SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Switzerland

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Open Research Data Pilot (1)

Data Management Plan (DMP)

Data Management Plan

Publikacje

Peer reviewed articles (18)

Schistosomiasis: cercarial finding and recognizing of human hosts as a prerequisite of invasion

Autorzy: Ursula Panzner, Jürg Utzinger, Jennifer Keiser
Opublikowane w: Clinical Microbiology Reviews, Numer 38, 2025, ISSN 0893-8512
Wydawca: American Society for Microbiology
DOI: 10.1128/cmr.00196-24

Emodepside for <i>Trichuris trichiura</i> and Hookworm Infection

Autorzy: Emmanuel C. Mrimi, Sophie Welsche, Said M. Ali, Jan Hattendorf, Jennifer Keiser
Opublikowane w: New England Journal of Medicine, Numer 388, 2024, Strona(/y) 1863-1875, ISSN 0028-4793
Wydawca: Massachusetts Medical Society
DOI: 10.1056/nejmoa2212825

Combined high-quality metagenomics reveals off-target effects of albendazole, ivermectin-albendazole and moxidectin-albendazole on the human gut bacteria

Autorzy: Julian Dommann, Viviane P. Sprecher, Christian Beisel, Daniel Ballmer, Eveline Hürlimann, Jean T. Coulibaly, Jennifer Keiser, Pierre H. H. Schneeberger
Opublikowane w: npj Biofilms and Microbiomes, 2026, ISSN 2055-5008
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41522-026-01018-3

Implementation of real-time PCR assays for diagnosing intestinal protozoa infections

Autorzy: Christian N. Lotz, Pierre H. H. Schneeberger, Maura Concu, Said M. Ali, Emmanuel C. Mrimi, Jennifer Keiser
Opublikowane w: Parasitology Research, Numer 124, 2025, ISSN 0932-0113
Wydawca: Springer Verlag
DOI: 10.1007/s00436-025-08483-3

Robenidine derivatives as potential antischistosomal drug candidates

Autorzy: Christian N. Lotz, Alina Krollenbrock, Lea Imhof, Michael Riscoe, Jennifer Keiser
Opublikowane w: International Journal for Parasitology: Drugs and Drug Resistance, Numer 25, 2024, Strona(/y) 100546, ISSN 2211-3207
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpddr.2024.100546

Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases

Autorzy: Pierre H. H. Schneeberger, Morgan Gueuning, Sophie Welsche, Eveline Hürlimann, Julian Dommann, Cécile Häberli, Jürg E. Frey, Somphou Sayasone, Jennifer Keiser
Opublikowane w: Nature Communications, Numer 13, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-28658-1

Widespread Trichuris incognita reveals hidden diversity and reshapes understanding of human whipworm infections

Autorzy: Nurudeen Rahman, Max A. Bär, Julian Dommann, Eveline Hürlimann, Jean T. Coulibaly, Said Ali, Somphou Sayasone, Prudence Beinamaryo, Jennifer Keiser, Pierre H. H. Schneeberger
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-64516-6

Efficacy and safety of emodepside compared with albendazole in adolescents and adults with hookworm infection in Pemba Island, Tanzania: a double-blind, superiority, phase 2b, randomised controlled trial

Autorzy: Lyndsay Taylor, Ahmada Ali Ahmada, Msanif Said Ali, Said Mohammed Ali, Jan Hattendorf, Ibrahim Said Mohammed, Jennifer Keiser
Opublikowane w: The Lancet, Numer 404, 2024, Strona(/y) 683-691, ISSN 0140-6736
Wydawca: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(24)01403-x

Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized controlled trials

Autorzy: Christian N. Lotz, Emmanuel C. Mrimi, Pierre H. H. Schneeberger, Said M. Ali, Jan Hattendorf, Jennifer Keiser
Opublikowane w: PLOS Neglected Tropical Diseases, Numer 19, 2025, Strona(/y) e0012872, ISSN 1935-2735
Wydawca: Public Library of Science (PLoS)
DOI: 10.1371/journal.pntd.0012872

Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit <i>Schistosoma mansoni</i> Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages

Autorzy: Roberto Gimmelli, Giuliana Papoff, Emanuele Fabbrizi, Michela Guida, Cristiana Lalli, Fulvio Saccoccia, Cécile Häberli, Jennifer Keiser, Daria Monaldi, Manfred Jung, Christophe Romier, Dante Rotili, Antonello Mai, Giovina Ruberti
Opublikowane w: ACS Infectious Diseases, Numer 11, 2025, Strona(/y) 3115-3127, ISSN 2373-8227
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/acsinfecdis.5c00515

Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of <i>Schistosoma mansoni</i>

Autorzy: Emanuele Fabbrizi, Gebremedhin Solomon Hailu, A. Ganesan, Rossella Fioravanti, Clemens Zwergel, Chiara Lambona, Sergio Valente, Giulia Fianco, Angela Iuzzolino, Daniela Trisciuoglio, Jonatan Caroli, Andrea Mattevi, Cécile Häberli, Jennifer Keiser, Dante Rotili, Antonello Mai
Opublikowane w: ACS Infectious Diseases, Numer 11, 2025, Strona(/y) 2178-2189, ISSN 2373-8227
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/acsinfecdis.5c00224

Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns

Autorzy: Pierre H. H. Schneeberger, Julian Dommann, Nurudeen Rahman, Eveline Hürlimann, Somphou Sayasone, Said Ali, Jean Tenena Coulibaly, Jennifer Keiser
Opublikowane w: npj Biofilms and Microbiomes, Numer 12, 2026, ISSN 2055-5008
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41522-026-00911-1

Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, In vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation

Autorzy: Godwin A. Dziwornu, Henrietta Dede Attram, Cécile Haeberli, Keabetswe Masike, Mathew Njoroge, Jennifer Keiser
Opublikowane w: European Journal of Medicinal Chemistry, Numer 284, 2025, Strona(/y) 117186, ISSN 0223-5234
Wydawca: Elsevier BV
DOI: 10.1016/j.ejmech.2024.117186

Present drugs and future perspectives in treating soil-transmitted helminthiasis

Autorzy: Jennifer Keiser
Opublikowane w: Frontiers in Tropical Diseases, Numer 4, 2023, ISSN 2673-7515
Wydawca: Frontiers Media SA
DOI: 10.3389/fitd.2023.1282725

A novel barcoded nanopore sequencing workflow of high-quality, full-length bacterial 16S amplicons for taxonomic annotation of bacterial isolates and complex microbial communities

Autorzy: Julian Dommann, Jakob Kerbl-Knapp, Diana Albertos Torres, Adrian Egli, Jennifer Keiser, Pierre H. H. Schneeberger
Opublikowane w: mSystems, Numer 9, 2024, ISSN 2379-5077
Wydawca: American Society for Microbiology
DOI: 10.1128/msystems.00859-24

Efficacy and safety of ascending doses of emodepside in comparison with ivermectin in adults infected with Strongyloides stercoralis in Laos: a phase 2a, dose-ranging, randomised, parallel-group, placebo-controlled, single-blind clinical trial

Autorzy: Lyndsay Taylor, Sysouphanh Many, Hannah Jeanguenat, Jan Hattendorf, Somphou Sayasone, Jennifer Keiser
Opublikowane w: The Lancet Infectious Diseases, Numer 25, 2025, Strona(/y) 1254-1264, ISSN 1473-3099
Wydawca: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(25)00255-5

Exposure of gut bacterial isolates to the anthelminthic drugs, ivermectin and moxidectin, leads to antibiotic-like phenotypes of growth inhibition and adaptation

Autorzy: Julian Dommann, Jennifer Keiser, Julian Garneau, Alison Gandelin, Carlo Casanova, Peter M. Keller, Somphou Sayasone, Pascale Vonaesch, Pierre H. H. Schneeberger
Opublikowane w: Communications Biology, Numer 7, 2024, ISSN 2399-3642
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-07135-z

Characterisation of Trichuris incognita n sp in Côte d’Ivoire: a morphological, genomic, and genome-wide association with drug sensitivity study

Autorzy: Max Alexander Bär, Nadège Akissi Kouamé, Sadikou Touré, Jean Tenena Coulibaly, Pierre Henri Hermann Schneeberger, Jennifer Keiser
Opublikowane w: The Lancet Microbe, Numer 7, 2026, Strona(/y) 101264, ISSN 2666-5247
Wydawca: Elsevier BV
DOI: 10.1016/j.lanmic.2025.101264