T-cell-induced immune programming and degeneration of the neuronal tissue during chronic autoimmunity

Informazioni relative al progetto

T-Neuron

ID dell’accordo di sovvenzione: 101021345

DOI

10.3030/101021345

Data della firma CE 10 Luglio 2021

Data di avvio 1 Settembre 2021

Data di completamento 31 Agosto 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 374 863,00

Contributo UE

€ 2 374 863,00

Coordinato da

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany

Periodic Reporting for period 3 - T-Neuron (T-cell-induced immune programming and degeneration of the neuronal tissue during chronic autoimmunity)

Periodo di rendicontazione: 2024-09-01 al 2026-02-28

Sintesi del contesto e degli obiettivi generali del progetto

The project investigates why multiple sclerosis, an autoimmune disease of the central nervous system, takes a chronic, progressive course. In particular, we are investigating which immune processes are responsible for the destruction of neurons in the brain, which are of central importance for the function of the organ. Multiple sclerosis is a disease that usually affects young adults and accompanies them throughout their lives. The illness can severely restrict the professional and personal development of those affected. To date there is no curative treatment. Most of the treatments available are expensive and they can only slow down the progression of the disease. Therefore, it is of enormous socioeconomic importance to gain progress on the pathophysiological basis of the chronic disease.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

The project developed experimental models that make it possible to largely reproduce human disease and tissue destruction. It has been shown that brain-specific T cells, which are important for the initiation of CNS autoimmune disease, can also cause progressive destruction of neurons. Methodological tools have also been developed to determine the molecular basis of this T cell-induced neuronal destruction.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

In the search for factors that control the pathogenic and destructive potential of brain-specific T cells in the CNS, an unexpected connection to the lungs was found. The newly discovered lung-brain axis is based on the composition of the lung microbiota. This determines how microglia – the brain’s resident immune cells – can react to inflammatory stimuli. By manipulating the lung microbiota, the susceptibility to developing autoimmune inflammation could be regulated. Ongoing studies should make it possible to reveal further new aspects of the cellular and molecular basis for the progressive neuronal destruction in CNS autoimmunity.

T cells (green) in contact with a neuron (red)