Project description
A virtual diagnostic tool for blood clotting
In coagulation disorders, the body cannot control the process of blood clotting, causing either bleeding or thrombosis. During blood clotting, the viscosity of the blood increases and the flow properties change. The EU-funded ViBRheo project proposes to exploit these alterations in the viscoelasticity of the blood for diagnostic purposes. Researchers will develop a computational approach that can detect alterations in the microstructural morphology of blood that undergoes clotting. They will also identify biomarkers associated with early stages of blood clotting that will assist in the continuous yet non-invasive monitoring of patients suffering from coagulation abnormalities.
Objective
Early-stage diagnosis and continuous non-invasive monitoring of coagulopathies is a challenging problem that has been exacerbated by the COVID-19 pandemic. In this context, viscoelastic characterisation of the whole blood and plasma represents an excellent diagnosis approach, incorporating implicitly several molecular factors. However, a careful interpretation of coagulation abnormalities and adaptation of the techniques to the new disease is needed. ViBRheo aims to construct a novel computational multiscale framework able to detect alterations in blood rheology during clot formations. The framework will account for variations of viscometric properties at clinically-relevant conditions, whereas incorporating large memory effects related to coagulation kinetics from the microscales. Our goal is to translate research models into clinical applications. Thus, facilitating the virtual calibration and the design of microfluidic devices to extract microstructural features of blood undergoing clotting. Additionally, ViBRheo will potentially lead to the definition of mechanistic biomarkers for early detection and easier monitoring of acute coagulopathy on COVID-19 patients. ViBRheo will count on the support of an interdisciplinary team, with broad expertise on medicine, modelling, engineering, physics, and applied mathematics. Furthermore, it will promote theoretical/experimental exchange on hemorheological results. The development of a computational tool is in line with the 2030 UN Sustainable Development Goals. It facilitates early response to unprecedented diseases with broad applicability in coagulation disorders, beyond the current COVID19-related coagulopathies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
48009 Bilbao
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.