Descripción del proyecto
Una herramienta de diagnóstico virtual en la formación de coágulos
En los trastornos en la coagulación, el organismo no puede controlar el proceso de la formación de coágulos, lo que produce ya sea sangrado o trombosis. En la formación de coágulos la viscosidad de la sangre aumenta y las propiedades del flujo cambian. El proyecto financiado con fondos europeos ViBRheo se propone aprovechar estas alteraciones en la viscoelasticidad de la sangre con fines diagnósticos. Los investigadores desarrollarán un método informático que pueda detectar alteraciones en la morfología microestructural de la sangre que subyacen a la coagulación. También identificarán biomarcadores asociados con etapas tempranas de la formación de coágulos que ayudarán a la monitorización continua, aunque no invasiva, de los pacientes con anomalías de la coagulación.
Objetivo
Early-stage diagnosis and continuous non-invasive monitoring of coagulopathies is a challenging problem that has been exacerbated by the COVID-19 pandemic. In this context, viscoelastic characterisation of the whole blood and plasma represents an excellent diagnosis approach, incorporating implicitly several molecular factors. However, a careful interpretation of coagulation abnormalities and adaptation of the techniques to the new disease is needed. ViBRheo aims to construct a novel computational multiscale framework able to detect alterations in blood rheology during clot formations. The framework will account for variations of viscometric properties at clinically-relevant conditions, whereas incorporating large memory effects related to coagulation kinetics from the microscales. Our goal is to translate research models into clinical applications. Thus, facilitating the virtual calibration and the design of microfluidic devices to extract microstructural features of blood undergoing clotting. Additionally, ViBRheo will potentially lead to the definition of mechanistic biomarkers for early detection and easier monitoring of acute coagulopathy on COVID-19 patients. ViBRheo will count on the support of an interdisciplinary team, with broad expertise on medicine, modelling, engineering, physics, and applied mathematics. Furthermore, it will promote theoretical/experimental exchange on hemorheological results. The development of a computational tool is in line with the 2030 UN Sustainable Development Goals. It facilitates early response to unprecedented diseases with broad applicability in coagulation disorders, beyond the current COVID19-related coagulopathies.
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MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinador
48009 Bilbao
España