Description du projet
Un outil de diagnostic virtuel pour la coagulation du sang
Les troubles de la coagulation empêchent l’organisme de contrôler le processus de coagulation du sang, ce qui entraîne soit des hémorragies, soit des thromboses. Lorsque le sang coagule, la viscosité du sang augmente et les propriétés de l’écoulement sanguin évoluent. Le projet ViBRheo, financé par l’UE, propose d’exploiter ces changements au niveau de la viscoélasticité du sang à des fins de diagnostic. Les chercheurs élaboreront une approche informatique capable de détecter les changements de la morphologie microstructurale du sang en pleine coagulation. En outre, ils identifieront les biomarqueurs associés aux premiers stades de la coagulation du sang qui favoriseront à la surveillance continue mais non invasive des patients souffrant de troubles de la coagulation.
Objectif
Early-stage diagnosis and continuous non-invasive monitoring of coagulopathies is a challenging problem that has been exacerbated by the COVID-19 pandemic. In this context, viscoelastic characterisation of the whole blood and plasma represents an excellent diagnosis approach, incorporating implicitly several molecular factors. However, a careful interpretation of coagulation abnormalities and adaptation of the techniques to the new disease is needed. ViBRheo aims to construct a novel computational multiscale framework able to detect alterations in blood rheology during clot formations. The framework will account for variations of viscometric properties at clinically-relevant conditions, whereas incorporating large memory effects related to coagulation kinetics from the microscales. Our goal is to translate research models into clinical applications. Thus, facilitating the virtual calibration and the design of microfluidic devices to extract microstructural features of blood undergoing clotting. Additionally, ViBRheo will potentially lead to the definition of mechanistic biomarkers for early detection and easier monitoring of acute coagulopathy on COVID-19 patients. ViBRheo will count on the support of an interdisciplinary team, with broad expertise on medicine, modelling, engineering, physics, and applied mathematics. Furthermore, it will promote theoretical/experimental exchange on hemorheological results. The development of a computational tool is in line with the 2030 UN Sustainable Development Goals. It facilitates early response to unprecedented diseases with broad applicability in coagulation disorders, beyond the current COVID19-related coagulopathies.
Champ scientifique
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Programme(s)
Régime de financement
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinateur
48009 Bilbao
Espagne