Designing new heterocyclic rings for use in medicinal chemistry
Funded under the Marie Skłodowska-Curie Actions programme, the PHOTOLITH project plans to develop new photochemical reactions involving conjugated anions with lithium counterions (organolithiums and enolates). The goal is to construct functionalised, fused heterocyclic frameworks for use in medicinal chemistry. N-Allyl/N-benzyllithiums tethered to aromatic and heteroaromatic carboxamides will be employed in dearomatising cyclisations for constructing partially saturated fused ring systems and generating extended lithium enolates. Visible light radiation at a low temperature will induce a series of photochemical rearrangements, delivering demanding products in terms of structure that will contain various heterocycles and hetero-fused skeletons based on norcaradienes, cycloheptatrienes and cyclic ketones.
Fields of science
- natural scienceschemical sciencesorganic chemistryketones
- medical and health sciencesbasic medicinemedicinal chemistry
- natural scienceschemical sciencesinorganic chemistryalkali metals
- natural scienceschemical sciencesphysical chemistryphotochemistry
- natural scienceschemical sciencesorganic chemistryheterocyclic compounds