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Novel Scaffolds by Mild Photochemical Rearrangement of Reactive Enolate and Organolithium Anions

Project description

Designing new heterocyclic rings for use in medicinal chemistry

Funded under the Marie Skłodowska-Curie Actions programme, the PHOTOLITH project plans to develop new photochemical reactions involving conjugated anions with lithium counterions (organolithiums and enolates). The goal is to construct functionalised, fused heterocyclic frameworks for use in medicinal chemistry. N-Allyl/N-benzyllithiums tethered to aromatic and heteroaromatic carboxamides will be employed in dearomatising cyclisations for constructing partially saturated fused ring systems and generating extended lithium enolates. Visible light radiation at a low temperature will induce a series of photochemical rearrangements, delivering demanding products in terms of structure that will contain various heterocycles and hetero-fused skeletons based on norcaradienes, cycloheptatrienes and cyclic ketones.


Net EU contribution
€ 212 933,76
Beacon House Queens Road
BS8 1QU Bristol
United Kingdom

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South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00