Computational modelling of the human brain lipidome

Project description

Modelling the blood–brain barrier

The blood–brain barrier (BBB) is a highly selective border that blocks access to the brain for pathogens and toxins. Although it helps maintain brain homeostasis, it also prevents certain medications for CNS disorders from reaching the brain. The EU-funded HumBrain project will build a model of the P-glycoprotein transporter which is located in the BBB endothelial cell membranes and effluxes drugs out of the brain. Through simulation of the molecular dynamics of this transporter with various substrates and inhibitors, scientists hope to understand the mechanism underlying BBB selectivity. Apart from providing fundamental knowledge, the project's results will pave the way for the design of the next generation of CNS modulators.

Fields of science

• natural sciences › mathematics › applied mathematics

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2020 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2020

See other projects for this call

Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

AARHUS UNIVERSITET

Net EU contribution

€ 207 312,00

Address

Nordre Ringgade 1
8000 Aarhus C
Denmark

Region

Danmark › Midtjylland › Østjylland

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00