Injury profiles and brain development after mild traumatic brain injury in children: An individualised and longitudinal approach

Información del proyecto

INITIATE

Identificador del acuerdo de subvención: 101024023

DOI

10.3030/101024023

Proyecto finalizado el 31 Octubre 2021

Fecha de la firma de la CE 9 Marzo 2021

Fecha de inicio 1 Abril 2021

Fecha de finalización 31 Marzo 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 162 806,40

Aportación de la UE

€ 162 806,40

Coordinado por

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

Periodic Reporting for period 1 - INITIATE (Injury profiles and brain development after mild traumatic brain injury in children: An individualised and longitudinal approach)

Período documentado: 2021-04-01 hasta 2023-03-31

Resumen del contexto y de los objetivos generales del proyecto

Paediatric mild traumatic brain injury (pmTBI) is a very common brain disorder that affects the brain during peak development. Its consequences are so variable and complex that the current “one size fits all” approach lacks the precision needed for individual prognosis, and targeted therapy of pmTBI. INITIATE aimed to identify the individual profile of injury and to evaluate changes in brain development following mTBI in children using advanced magnetic resonance imaging (MRI) and individualised longitudinal statistical analyses.

This MSCA fellowship has been early terminated after 7 months duration because the experienced researcher has been appointed as young researcher at the French National Institute for Research in Digital Science and Technology (Inria). Even shorter than planned, this MSCA followship allowed me to fully develop as an independent researcher and to be ready to lead my own team in the field of paediatric TBI and brain development. The fellowship allowed me to strengthen and broaden my expertise in longitudinal analysis to brain development, as well as enable me to further improve my qualities of independent researcher. In addition, the 2-month secondment at the University of Oslo (Norway) allowed me to collaborate with researcher from different disciplines and universities, and to experience new research environment and culture.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

The pandemic and associated restrictions significantly slowed done the rate of recruitment of the participants (22 8-16-year-old children with a mild traumatic brain injury recruited over the 7 months duration of the project). As contingency plan and to ensure reaching the training objective of the fellowship, I used publicly available data from the large population-cohort study Adolescent Brain Cognitive Development (ABCD) to characterized longitudinal changes in social behaviour and social brain cortical thickness in young adolescents with a childhood history of mTBI (retrospective reported by the parent). The results of this study will be disseminated in an open access scientific publication in the coming months.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

By providing new knowledge on the impact of mTBI sustained during childhood on child’s development of social behaviour and brain structure, INITIATE contributes towards the H2020’s objective to reduce the societal burden of brain disorders.

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