Injury profiles and brain development after mild traumatic brain injury in children: An individualised and longitudinal approach

Informazioni relative al progetto

INITIATE

ID dell’accordo di sovvenzione: 101024023

DOI

10.3030/101024023

Progetto concluso il 31 Ottobre 2021

Data della firma CE 9 Marzo 2021

Data di avvio 1 Aprile 2021

Data di completamento 31 Marzo 2023

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 162 806,40

Contributo UE

€ 162 806,40

Coordinato da

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

Periodic Reporting for period 1 - INITIATE (Injury profiles and brain development after mild traumatic brain injury in children: An individualised and longitudinal approach)

Periodo di rendicontazione: 2021-04-01 al 2023-03-31

Sintesi del contesto e degli obiettivi generali del progetto

Paediatric mild traumatic brain injury (pmTBI) is a very common brain disorder that affects the brain during peak development. Its consequences are so variable and complex that the current “one size fits all” approach lacks the precision needed for individual prognosis, and targeted therapy of pmTBI. INITIATE aimed to identify the individual profile of injury and to evaluate changes in brain development following mTBI in children using advanced magnetic resonance imaging (MRI) and individualised longitudinal statistical analyses.

This MSCA fellowship has been early terminated after 7 months duration because the experienced researcher has been appointed as young researcher at the French National Institute for Research in Digital Science and Technology (Inria). Even shorter than planned, this MSCA followship allowed me to fully develop as an independent researcher and to be ready to lead my own team in the field of paediatric TBI and brain development. The fellowship allowed me to strengthen and broaden my expertise in longitudinal analysis to brain development, as well as enable me to further improve my qualities of independent researcher. In addition, the 2-month secondment at the University of Oslo (Norway) allowed me to collaborate with researcher from different disciplines and universities, and to experience new research environment and culture.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

The pandemic and associated restrictions significantly slowed done the rate of recruitment of the participants (22 8-16-year-old children with a mild traumatic brain injury recruited over the 7 months duration of the project). As contingency plan and to ensure reaching the training objective of the fellowship, I used publicly available data from the large population-cohort study Adolescent Brain Cognitive Development (ABCD) to characterized longitudinal changes in social behaviour and social brain cortical thickness in young adolescents with a childhood history of mTBI (retrospective reported by the parent). The results of this study will be disseminated in an open access scientific publication in the coming months.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

By providing new knowledge on the impact of mTBI sustained during childhood on child’s development of social behaviour and brain structure, INITIATE contributes towards the H2020’s objective to reduce the societal burden of brain disorders.

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