Injury profiles and brain development after mild traumatic brain injury in children: An individualised and longitudinal approach

Informations projet

INITIATE

N° de convention de subvention: 101024023

DOI

10.3030/101024023

Projet clôturé le 31 Octobre 2021

Date de signature de la CE 9 Mars 2021

Date de début 1 Avril 2021

Date de fin 31 Mars 2023

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 162 806,40

Contribution de l’UE

€ 162 806,40

Coordonné par

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

Periodic Reporting for period 1 - INITIATE (Injury profiles and brain development after mild traumatic brain injury in children: An individualised and longitudinal approach)

Période du rapport: 2021-04-01 au 2023-03-31

Résumé du contexte et des objectifs généraux du projet

Paediatric mild traumatic brain injury (pmTBI) is a very common brain disorder that affects the brain during peak development. Its consequences are so variable and complex that the current “one size fits all” approach lacks the precision needed for individual prognosis, and targeted therapy of pmTBI. INITIATE aimed to identify the individual profile of injury and to evaluate changes in brain development following mTBI in children using advanced magnetic resonance imaging (MRI) and individualised longitudinal statistical analyses.

This MSCA fellowship has been early terminated after 7 months duration because the experienced researcher has been appointed as young researcher at the French National Institute for Research in Digital Science and Technology (Inria). Even shorter than planned, this MSCA followship allowed me to fully develop as an independent researcher and to be ready to lead my own team in the field of paediatric TBI and brain development. The fellowship allowed me to strengthen and broaden my expertise in longitudinal analysis to brain development, as well as enable me to further improve my qualities of independent researcher. In addition, the 2-month secondment at the University of Oslo (Norway) allowed me to collaborate with researcher from different disciplines and universities, and to experience new research environment and culture.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

The pandemic and associated restrictions significantly slowed done the rate of recruitment of the participants (22 8-16-year-old children with a mild traumatic brain injury recruited over the 7 months duration of the project). As contingency plan and to ensure reaching the training objective of the fellowship, I used publicly available data from the large population-cohort study Adolescent Brain Cognitive Development (ABCD) to characterized longitudinal changes in social behaviour and social brain cortical thickness in young adolescents with a childhood history of mTBI (retrospective reported by the parent). The results of this study will be disseminated in an open access scientific publication in the coming months.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

By providing new knowledge on the impact of mTBI sustained during childhood on child’s development of social behaviour and brain structure, INITIATE contributes towards the H2020’s objective to reduce the societal burden of brain disorders.

picture-1.png