Injury profiles and brain development after mild traumatic brain injury in children: An individualised and longitudinal approach

Projektinformationen

INITIATE

ID Finanzhilfevereinbarung: 101024023

DOI

10.3030/101024023

Das Projekt endete am 31 Oktober 2021

EK-Unterschriftsdatum 9 März 2021

Startdatum 1 April 2021

Enddatum 31 März 2023

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 162 806,40

EU-Beitrag

€ 162 806,40

Koordiniert durch

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

Periodic Reporting for period 1 - INITIATE (Injury profiles and brain development after mild traumatic brain injury in children: An individualised and longitudinal approach)

Berichtszeitraum: 2021-04-01 bis 2023-03-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Paediatric mild traumatic brain injury (pmTBI) is a very common brain disorder that affects the brain during peak development. Its consequences are so variable and complex that the current “one size fits all” approach lacks the precision needed for individual prognosis, and targeted therapy of pmTBI. INITIATE aimed to identify the individual profile of injury and to evaluate changes in brain development following mTBI in children using advanced magnetic resonance imaging (MRI) and individualised longitudinal statistical analyses.

This MSCA fellowship has been early terminated after 7 months duration because the experienced researcher has been appointed as young researcher at the French National Institute for Research in Digital Science and Technology (Inria). Even shorter than planned, this MSCA followship allowed me to fully develop as an independent researcher and to be ready to lead my own team in the field of paediatric TBI and brain development. The fellowship allowed me to strengthen and broaden my expertise in longitudinal analysis to brain development, as well as enable me to further improve my qualities of independent researcher. In addition, the 2-month secondment at the University of Oslo (Norway) allowed me to collaborate with researcher from different disciplines and universities, and to experience new research environment and culture.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

The pandemic and associated restrictions significantly slowed done the rate of recruitment of the participants (22 8-16-year-old children with a mild traumatic brain injury recruited over the 7 months duration of the project). As contingency plan and to ensure reaching the training objective of the fellowship, I used publicly available data from the large population-cohort study Adolescent Brain Cognitive Development (ABCD) to characterized longitudinal changes in social behaviour and social brain cortical thickness in young adolescents with a childhood history of mTBI (retrospective reported by the parent). The results of this study will be disseminated in an open access scientific publication in the coming months.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

By providing new knowledge on the impact of mTBI sustained during childhood on child’s development of social behaviour and brain structure, INITIATE contributes towards the H2020’s objective to reduce the societal burden of brain disorders.

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