Description du projet
Une méthode non invasive pour mesurer la dopamine
La dopamine est un médicament soumis à prescription utilisé pour traiter l’hypotension et améliorer le flux sanguin vers les reins. Les agonistes dopaminergiques servent également pour traiter la maladie de Parkinson et le syndrome des jambes sans repos, un problème courant chez les personnes atteintes de cette maladie. Dans ce contexte, le projet BEACON, financé par l’UE, développera un patch portable pour la détection continue de la dopamine. Plus précisément, il utilisera des matériaux biocompatibles et des techniques de fabrication additive qui permettront une surveillance 24 heures sur 24 de cette hormone. Ce dispositif non invasif, qui analyse la concentration de dopamine dans la sueur humaine, assurera sa propre alimentation en utilisant la chaleur du corps du patient comme source d’énergie.
Objectif
The following proposal deals with the fabrication and validation of a wearable patch for continuous dopamine sensing, realized using biocompatible materials and additive manufacturing techniques, which would allow to monitor the evolution throughout the day of this hormone which is fundamental in the treatment of many neurological diseases. The candidate wants to provide a simple and non-invasive method which could potentially improve the quality of life of millions of patients and families affected by these diseases and reduce the growing social costs to treat them. The device is thought to be self-powered, using the patients’ body heat as energy source, and works by analysing the dopamine concentration in human sweat, therefore no surgical procedure is required. To detect dopamine concentration, organic electrochemical transistors are used, exploiting their amplification ability to obtain a highly sensitive monitoring device. The patch is also equipped with a radio-frequency antenna for data transmission to medical personnel monitoring real-time the dopamine evolution in the patients. Finally, the patch is designed to be conformable, lightweight and cheap to reduce the patients’ discomfort.
Champ scientifique
Mots‑clés
Programme(s)
Régime de financement
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinateur
581 83 Linkoping
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