Description du projet
Différences fondées sur le sexe dans l’induction de la mort cellulaire associée à l’IRI
La lésion d’ischémie‑reperfusion (IRI) se produit pendant la restauration du flux sanguin coronaire après un infarctus du myocarde (IM). La physiopathologie du dysfonctionnement et de la mort des cardiomyocytes pendant l’IRI est bien étudiée, mais la pertinence des différences liées au sexe dans ce contexte est mal comprise. L’objectif du projet SEXOGENIRI, financé par l’UE, est d’élucider l’effet du sexe biologique dans l’induction de la mort cellulaire au cours de l’IRI. Le projet examinera des cœurs de souris et d’humains à l’aide d’un panel de techniques, dont la chirurgie in vivo, l’évaluation de lignées cellulaires in vitro, la microscopie de pointe, l’étude de la respiration mitochondriale et les méthodes traditionnelles de biologie moléculaire.
Objectif
Acute myocardial infarction (MI) accounts for millions of morbidity and mortality cases worldwide. While the underlying pathophysiology of cardiomyocyte dysfunction and death during MI-related ischaemia/reperfusion injury (IRI), which occurs due to the restoration of coronary blood flow after MI, is well established, the relevance of sex-based differences in this context is poorly understood. In this action, we aim at understanding the effect of biological sex in the induction of a novel form of cell death in the setting of IRI. The project will examine both mouse and human hearts and will benefit from a range of techniques including, but not limited to in vivo surgery, in vitro cell line evaluation, state-of-the-art microscopy, mitochondrial respirometry and molecular biology methods. The content of the action will enable the researcher to restart his career and gain important academic, interpersonal and laboratory skills. It will also provide an opportunity for the researcher to publish in major journals and disseminate his findings to scientists and the public, which will ultimately help him establish himself in the field of cardiovascular science. The action also helps raise the research and academic profile of the host team and institution and contribute to the development of strong intra-European science networking. Overall, this action aims at contributing to the scientific progress of the researcher and pave the way for the identification of novel therapeutic targets for IRI with direct translational potential.
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MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinateur
101 Reykjavik
Islande