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Trace Amine-Associated Receptor 1 (TAAR1) agonists in a chemogenetic/molecular imaging model of increased dopamine synthesis capacity (Ki)

Project description

Trace amine-associated receptor 1 as a new molecular target in schizophrenia investigation

The study of the functional role of striatal dopamine (DA) signalling is necessary due to its wide-ranging impact on learning, motivational and motor processes. DA over-reactivity is the most well-established pathophysiological mechanism underlying schizophrenia. The EU-funded TACtIK project aims to introduce an innovative chemogenetic/positron emission tomography (PET) imaging model of striatal DA over-reactivity to test the efficacy of new antipsychotic compounds that target the trace amine-associated receptor 1 (TAAR1). The goal is to develop a mouse model of increased pre-synaptic DA synthesis capacity (Ki) in the striatum and to determine if TAAR1 agonists decrease striatal Ki in the model and in patients with a diagnosis of schizophrenia.

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Net EU contribution
€ 212 933,76
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00