Adaptation of human brown adipose tissue to overnutrition

Projektinformationen

BATON

ID Finanzhilfevereinbarung: 101028941

DOI

10.3030/101028941

Das Projekt endete am 31 August 2025

EK-Unterschriftsdatum 6 April 2021

Startdatum 1 April 2022

Enddatum 19 September 2025

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 250 497,60

EU-Beitrag

€ 250 497,60

Koordiniert durch

UNIVERSIDAD DE GRANADA
Spain

Periodic Reporting for period 2 - BATON (Adaptation of human brown adipose tissue to overnutrition)

Berichtszeitraum: 2024-04-01 bis 2025-03-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Brown adipose tissue (BAT) is highly thermogenic and produces heat to maintain mammals’ body temperature. BAT’s role in adaptation to overfeeding and protecting from diet-induced obesity is well established in rodents. A decade ago, several research teams confirmed the presence of metabolically active BAT in human adults. The EU-funded BATON project develops a new method of precise measurement of human BAT volume and thermogenic capacity. The approach is based on recent advances in human BAT metabolism and will involve a randomized crossover study with 10 healthy adults. The developed method will be applied in the proof-of-concept study of BAT volume and thermogenic capacity changes in response to overfeeding.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

The first part of the project has been successfully completed. Overall, the results of the study performed within WP2, refuted the initial hypotheses: 48 µg of inhaled formoterol does not increase BAT thermogenesis, nor increase whole-body energy expenditure. These results have been disseminated in scientific conferences and a manuscript reporting these results in detail is in preparation.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

After having completed its method-development phase, the project will now switch towards investigating the adaptations suffered by human BAT in response to a sustained alteration of energy balance. This will help understanding the role of this tissue in human weight management.

Poster sumarizing the main results of experiment 1