Adaptation of human brown adipose tissue to overnutrition

Informacje na temat projektu

BATON

Identyfikator umowy o grant: 101028941

DOI

10.3030/101028941

Realizacja projektu zakończyła się 31 Sierpnia 2025

Data podpisania przez KE 6 Kwietnia 2021

Data rozpoczęcia 1 Kwietnia 2022

Data zakończenia 19 Września 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 250 497,60

Wkład UE

€ 250 497,60

Koordynowany przez

UNIVERSIDAD DE GRANADA
Spain

Periodic Reporting for period 2 - BATON (Adaptation of human brown adipose tissue to overnutrition)

Okres sprawozdawczy: 2024-04-01 do 2025-03-31

Podsumowanie kontekstu i ogólnych celów projektu

Brown adipose tissue (BAT) is highly thermogenic and produces heat to maintain mammals’ body temperature. BAT’s role in adaptation to overfeeding and protecting from diet-induced obesity is well established in rodents. A decade ago, several research teams confirmed the presence of metabolically active BAT in human adults. The EU-funded BATON project develops a new method of precise measurement of human BAT volume and thermogenic capacity. The approach is based on recent advances in human BAT metabolism and will involve a randomized crossover study with 10 healthy adults. The developed method will be applied in the proof-of-concept study of BAT volume and thermogenic capacity changes in response to overfeeding.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

The first part of the project has been successfully completed. Overall, the results of the study performed within WP2, refuted the initial hypotheses: 48 µg of inhaled formoterol does not increase BAT thermogenesis, nor increase whole-body energy expenditure. These results have been disseminated in scientific conferences and a manuscript reporting these results in detail is in preparation.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

After having completed its method-development phase, the project will now switch towards investigating the adaptations suffered by human BAT in response to a sustained alteration of energy balance. This will help understanding the role of this tissue in human weight management.

Poster sumarizing the main results of experiment 1