Descripción del proyecto DEENESFRITPL Un dispositivo de uso en el punto de atención para el diagnóstico del cáncer de mama Un diagnóstico rápido del cáncer requiere pruebas sensibles en el punto de atención capaces de detectar de manera fiable los biomarcadores secretados por las células cancerígenas. El proyecto financiado con fondos europeos SERENA se centra en el desarrollo de una plataforma multisensor que puede detectar microARN y ARN no codificantes de cadena larga asociados con el cáncer de mama. El dispositivo incluirá sensores basados en la nanotecnología para la realización de análisis de sangre completa en el punto de atención. Dado que el cáncer de mama es una de las formas de cáncer con mayor incidencia en mujeres, se espera que el dispositivo SERENA mejore no solo su diagnóstico, sino también y pronóstico y seguimiento. Mostrar el objetivo del proyecto Ocultar el objetivo del proyecto Objetivo This proposal aims to address the unmet needs, opportunities, and challenges in the field of liquid biopsy and PoC devices for the detection of emerging cancer biomarkers in blood. Circulating microRNAs and long non-coding RNAs as well as autoantibodies are promising cancer biomarkers for liquid biopsy. My goal is to develop a rapid, portable, easy-use, and reliable electrochemical nanostructured multisensor platform for their simultaneous detection in whole blood for early breast cancer diagnosis, prognosis and patient follow-up. I will merge the advantages of nucleic acid analogues with those of graphene-nanoparticle hybrid composites to develop a platform based on the use of inexpensive screen printed electrodes, produced by cutting-edge green technologies.An interdisciplinary approach will drive me towards the development and delivery of this novel diagnostic device with tremendous potential in nanomedicine. This fellowship aims to build on my recognised background in DNA nanotechnology and achieve new complementary expertise in electrochemistry, cutting-edge nanotechnology and nanoscience-based biosensors, through knowledge transfer and related training activities under the supervision of Prof. Merkoçi, a world-renowned expert in these fields. Meanwhile, the host institution (ICN2) will benefit from my skills in DNA nanotechnology for bioanalytical applications. Moreover, this fellowship will allow me to refine and acquire complementary transferable skills, including proposal writing, patents and IPR, project management, and leadership skills. I intend also exploit the opportunities to develop professionally by supporting the ICN2 Communication Department and by getting involved in the ICN2’s gender actions.The original scientific output and added-value career development benefits of this fellowship would greatly support me in gaining the necessary skills and credentials to become an independent and productive European PI. Ámbito científico natural scienceschemical scienceselectrochemistrynatural sciencesbiological sciencesgeneticsDNAengineering and technologynanotechnologymedical and health sciencesmedical biotechnologynanomedicinemedical and health sciencesclinical medicineoncologybreast cancer Palabras clave artificial nucleic acids biosensors Point-Of-Care device printing technology Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2020 - Individual Fellowships Convocatoria de propuestas H2020-MSCA-IF-2020 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinador FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA Aportación neta de la UEn € 160 932,48 Dirección CAMPUS DE LA UAB EDIFICI Q ICN2 08193 Cerdanyola Del Valles España Ver en el mapa Región Este Cataluña Barcelona Tipo de actividad Research Organisations Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 160 932,48
