Description du projet
Un test sur le lieu d’intervention pour un diagnostic du cancer du sein
Le diagnostic rapide du cancer nécessite des tests sensibles sur le lieu d’intervention, capables de détecter de manière fiable les biomarqueurs sécrétés par les cellules cancéreuses. Le projet SERENA, financé par l’UE, porte sur le développement d’une plateforme multicapteurs capable de détecter les microARN et les ARN non codants longs associés au cancer du sein. Le dispositif contiendra des capteurs basés sur les nanotechnologies pour l’analyse du sang total sur le lieu d’intervention. Le cancer du sein étant l’une des formes de cancer les plus répandues chez les femmes, le dispositif SERENA devrait améliorer non seulement le diagnostic, mais aussi le pronostic et le suivi.
Objectif
This proposal aims to address the unmet needs, opportunities, and challenges in the field of liquid biopsy and PoC devices for the detection of emerging cancer biomarkers in blood.
Circulating microRNAs and long non-coding RNAs as well as autoantibodies are promising cancer biomarkers for liquid biopsy.
My goal is to develop a rapid, portable, easy-use, and reliable electrochemical nanostructured multisensor platform for their simultaneous detection in whole blood for early breast cancer diagnosis, prognosis and patient follow-up. I will merge the advantages of nucleic acid analogues with those of graphene-nanoparticle hybrid composites to develop a platform based on the use of inexpensive screen printed electrodes, produced by cutting-edge green technologies.
An interdisciplinary approach will drive me towards the development and delivery of this novel diagnostic device with tremendous potential in nanomedicine.
This fellowship aims to build on my recognised background in DNA nanotechnology and achieve new complementary expertise in electrochemistry, cutting-edge nanotechnology and nanoscience-based biosensors, through knowledge transfer and related training activities under the supervision of Prof. Merkoçi, a world-renowned expert in these fields. Meanwhile, the host institution (ICN2) will benefit from my skills in DNA nanotechnology for bioanalytical applications.
Moreover, this fellowship will allow me to refine and acquire complementary transferable skills, including proposal writing, patents and IPR, project management, and leadership skills. I intend also exploit the opportunities to develop professionally by supporting the ICN2 Communication Department and by getting involved in the ICN2’s gender actions.
The original scientific output and added-value career development benefits of this fellowship would greatly support me in gaining the necessary skills and credentials to become an independent and productive European PI.
Champ scientifique
Programme(s)
Régime de financement
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinateur
08193 Cerdanyola Del Valles
Espagne