Projektbeschreibung
Ein patientennaher Test zur Brustkrebsdiagnose
Eine schnelle Krebsdiagnose ist nur mit empfindlichen, patientennahen Tests möglich, die in der Lage sind, von Krebszellen abgegebene Biomarker zuverlässig aufzuspüren. Das EU-finanzierte Projekt SERENA konzentriert sich auf die Entwicklung einer Multisensorplattform, die mit Brustkrebs assoziierte microRNA und lange, nicht kodierende RNA erkennen kann. Die Vorrichtung wird nanotechnologisch basierte Sensoren zur patientennahen Blutanalyse einsetzen. In Anbetracht der Tatsache, dass Brustkrebs die am häufigsten auftretende Krebsart bei Frauen ist, wird die SERENA-Vorrichtung voraussichtlich nicht nur die Diagnose, sondern auch die Krankheitsprognose und Nachbetreuung verbessern.
Ziel
This proposal aims to address the unmet needs, opportunities, and challenges in the field of liquid biopsy and PoC devices for the detection of emerging cancer biomarkers in blood.
Circulating microRNAs and long non-coding RNAs as well as autoantibodies are promising cancer biomarkers for liquid biopsy.
My goal is to develop a rapid, portable, easy-use, and reliable electrochemical nanostructured multisensor platform for their simultaneous detection in whole blood for early breast cancer diagnosis, prognosis and patient follow-up. I will merge the advantages of nucleic acid analogues with those of graphene-nanoparticle hybrid composites to develop a platform based on the use of inexpensive screen printed electrodes, produced by cutting-edge green technologies.
An interdisciplinary approach will drive me towards the development and delivery of this novel diagnostic device with tremendous potential in nanomedicine.
This fellowship aims to build on my recognised background in DNA nanotechnology and achieve new complementary expertise in electrochemistry, cutting-edge nanotechnology and nanoscience-based biosensors, through knowledge transfer and related training activities under the supervision of Prof. Merkoçi, a world-renowned expert in these fields. Meanwhile, the host institution (ICN2) will benefit from my skills in DNA nanotechnology for bioanalytical applications.
Moreover, this fellowship will allow me to refine and acquire complementary transferable skills, including proposal writing, patents and IPR, project management, and leadership skills. I intend also exploit the opportunities to develop professionally by supporting the ICN2 Communication Department and by getting involved in the ICN2’s gender actions.
The original scientific output and added-value career development benefits of this fellowship would greatly support me in gaining the necessary skills and credentials to become an independent and productive European PI.
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MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Koordinator
08193 Cerdanyola Del Valles
Spanien