Towards more sophisticated anti-cancer therapies
Chimeric antigen receptor (CAR) T cells have emerged as powerful anti-cancer weapons, demonstrating great clinical efficacy against haematological malignancies. However, prolonged antigen stimulation has hampered their effectiveness against solid tumours. The EU-funded Tex-Mex project will investigate the biomechanical triggers of the tumour microenvironment on prolonged T cell stimulation and dysfunction. Researchers will employ a microfluidic model that recapitulates all known parameters of T cell exhaustion and add a biomechanical dimension. Results will help address the bottleneck of CAR-T therapy associated with T cell exhaustion and advance it to a universal anti-cancer therapy.