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A synthetic biology approach to engineering exhaustion-free T cell therapies. Uncovering and counteracting biomechanical triggers of T cell dysfunction in the tumour microenvironment.

Project description

Towards more sophisticated anti-cancer therapies

Chimeric antigen receptor (CAR) T cells have emerged as powerful anti-cancer weapons, demonstrating great clinical efficacy against haematological malignancies. However, prolonged antigen stimulation has hampered their effectiveness against solid tumours. The EU-funded Tex-Mex project will investigate the biomechanical triggers of the tumour microenvironment on prolonged T cell stimulation and dysfunction. Researchers will employ a microfluidic model that recapitulates all known parameters of T cell exhaustion and add a biomechanical dimension. Results will help address the bottleneck of CAR-T therapy associated with T cell exhaustion and advance it to a universal anti-cancer therapy.

Coordinator

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Net EU contribution
€ 171 473,28
Address
Via Morego 30
16163 Genova
Italy

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Region
Nord-Ovest Liguria Genova
Activity type
Research Organisations
Non-EU contribution
€ 0,00