Molecular mechanisms and dynamics of in vivo glia-to-neuron reprogramming
Recent studies have demonstrated the possibility of direct reprogramming of brain glia into neurons in vivo paving the way for future regeneration of neurons damaged by injury or disease. However, the molecular underpinnings of glia-to-neuron conversion are still poorly understood. Funded by the Marie Skłodowska-Curie Actions programme, Neuro-ReprOmics will address the question of how neurogenic reprogramming factors remodel gene expression programmes during glial cell conversion into induced neurons. The study will utilise defined combinations of reprogramming factors leading to the generation of distinct types of neurons as well as single-cell RNA and assay for transposase-accessible chromatin sequencing to elucidate the reprogramming trajectories, mechanisms, and epigenomic changes that drive the process.
Fields of science
Call for proposalSee other projects for this call
Funding SchemeMSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
WC2R 2LS London
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