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Deconstructing in vivo glia-to-neuron conversion

Project description

Molecular mechanisms and dynamics of in vivo glia-to-neuron reprogramming

Recent studies have demonstrated the possibility of direct reprogramming of brain glia into neurons in vivo paving the way for future regeneration of neurons damaged by injury or disease. However, the molecular underpinnings of glia-to-neuron conversion are still poorly understood. Funded by the Marie Skłodowska-Curie Actions programme, Neuro-ReprOmics will address the question of how neurogenic reprogramming factors remodel gene expression programmes during glial cell conversion into induced neurons. The study will utilise defined combinations of reprogramming factors leading to the generation of distinct types of neurons as well as single-cell RNA and assay for transposase-accessible chromatin sequencing to elucidate the reprogramming trajectories, mechanisms, and epigenomic changes that drive the process.


Net EU contribution
€ 212 933,76
WC2R 2LS London
United Kingdom

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London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00