Descrizione del progetto
Visione meccanicistica della mindfulness e dello stress cronico
Lo stress cronico è correlato a modifiche cerebrali e del sistema immunitario che comportano un rischio elevato di problemi legati alla salute mentale e fisica. La mindfulness può proteggere la nostra salute dallo stress, ma le modalità con cui agisce non sono chiare. Il progetto INSPIRER, finanziato dall’UE, svilupperà e collauderà un modello in grado di scoprire i meccanismi psicologici, neurali e immunitari degli interventi di mindfulness. Tale modello può essere ulteriormente applicato per individuare gli interventi più efficaci nel mitigare gli effetti dello stress cronico e proteggere la salute delle persone.
Obiettivo
Lifetime stress and trauma have detrimental consequences on the brain and immune system in the form of chronic inflammation that increases risk for the majority of leading causes of morbidity in Europe, such as cardiovascular diseases. Mindfulness interventions seem to be able to counteract the effects of chronic stress, and to protect mental and physical health, but the underlying mechanisms are not yet fully understood. This fellowship aims to test and further develop an interdisciplinary framework (INSPIRER) that integrates psychological, neural, genomic and immune mechanisms of mindfulness interventions. To this aim, three studies will be conducted. First, a systematic review of the extant evidence that supports the INSPIRER will be conducted. Second, long-term mindfulness meditators will be compared with non-meditators in terms of neural and immune outcome measures in a cross-sectional study. Third, these outcomes will be used to compare an 8-week mindfulness intervention with an active control group through a randomised controlled trial. The studies will apply methods from psychology (a computerised cognitive task and questionnaires), neuroscience (structural and functional MRI) and immunology (biomarkers of inflammation). In addition to testing the neural and immune mechanisms, the two empirical studies will include an experimental induction of either physiological stress or social stress to directly test if mindfulness increases resilience. The INSPIRER has the potential to influence several research areas, as well to provide practical guidelines about which interventions are the most effective in mitigating the effects of chronic stress and concomitant inflammation. Besides conducting three studies, this fellowship will include extensive training across disciplines that will get me closer to my long-term goal of creating a strong network of collaborators in Europe and becoming a leading academic in mind-body interventions and stress.
Campo scientifico (EuroSciVoc)
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
- scienze naturaliscienze biologicheneurobiologia
- scienze mediche e della salutemedicina di baseimmunologia
- scienze socialipsicologia
- scienze mediche e della salutemedicina clinicacardiologiamalattie cardiovascolari
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Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinatore
1012WX Amsterdam
Paesi Bassi