environmentAL Toxicity chEmical mixtuRes through aN innovative platform based on aged cardiac tissue model

Project description

Environmental chemical exposure weighs heavy on the heart

Toxic chemicals are omnipresent in the environment. From pesticides to drug traces in water, soil, air and living organisms, people are continuously exposed to a huge amount and variety of potentially toxic substances. At the same time, a growing occurrence of cardiovascular diseases has been observed, leading to the hypothesis that the two phenomena are related. To address this issue, the EU-funded ALTERNATIVE project will develop a platform that enables the identification, quantification and prevention of cardiotoxic co-exposures to industrial chemicals and pharmaceuticals. The platform will consist of a three-dimensional in vitro model mimicking the human cardiac tissue, coupled with a reliable, high-throughput monitoring system based on multi-omics analyses and integrated into a machine-learning risk assessment tool.

Fields of science

• medical and health sciences › medical biotechnology › tissue engineering
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases

Programme(s)

• H2020-EU.3.5. - SOCIETAL CHALLENGES - Climate action, Environment, Resource Efficiency and Raw Materials

Topic(s)

• LC-GD-8-2-2020 - Fostering regulatory science to address combined exposures to industrial chemicals and pharmaceuticals: from science to evidence-based policies

Call for proposal

H2020-LC-GD-2020-3
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

POLITECNICO DI TORINO

Address

Corso Duca Degli Abruzzi 24
10129 Torino
Italy

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 592 300

Participants (10)

SCIENSANO

Belgium

EU contribution

€ 460 051

Address

Juliette Wytsmanstraat 14
1050 Elsene

Activity type

Research Organisations

SI ES TI EOOD

Bulgaria

EU contribution

€ 198 750

Address

Al. Stamobliysky 18
6500 Svilengrad

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

ELVESYS

France

EU contribution

€ 473 218,75

Address

172 Rue De Charonne B2 2 Eme Etage
75011 Paris

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU contribution

€ 569 500

Address

Piazzale Aldo Moro 7
00185 Roma

Activity type

Research Organisations

FUNDACIO EURECAT

Spain

EU contribution

€ 1 439 437,50

Address

Avenida Universitat Autonoma 23
08290 Cerdanyola Del Valles (Barcelona)

Activity type

Research Organisations

EURESCOM-EUROPEAN INSTITUTE FOR RESEARCH AND STRATEGIC STUDIES IN TELECOMMUNICATIONS GMBH

Germany

EU contribution

€ 468 250

Address

Wieblinger Weg 19/4
69123 Heidelberg

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

Italy

EU contribution

€ 386 750

Address

Via Mario Negri 2
20156 Milano

Activity type

Research Organisations

IVTECH SRL

Italy

EU contribution

€ 306 750

Address

Via Di Bagnaia
55054 Massarosa

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

UNIVERSITEIT UTRECHT

Netherlands

EU contribution

€ 362 500

Address

Heidelberglaan 8
3584 CS Utrecht

Activity type

Higher or Secondary Education Establishments

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

EU contribution

€ 242 250

Address

Christoph Probst Platz 1
6020 Innsbruck

Activity type

Higher or Secondary Education Establishments