Project description DEENESFRITPL Environmental chemical exposure weighs heavy on the heart Toxic chemicals are omnipresent in the environment. From pesticides to drug traces in water, soil, air and living organisms, people are continuously exposed to a huge amount and variety of potentially toxic substances. At the same time, a growing occurrence of cardiovascular diseases has been observed, leading to the hypothesis that the two phenomena are related. To address this issue, the EU-funded ALTERNATIVE project will develop a platform that enables the identification, quantification and prevention of cardiotoxic co-exposures to industrial chemicals and pharmaceuticals. The platform will consist of a three-dimensional in vitro model mimicking the human cardiac tissue, coupled with a reliable, high-throughput monitoring system based on multi-omics analyses and integrated into a machine-learning risk assessment tool. Show the project objective Hide the project objective Objective ALTERNATIVE will develop an innovative platform able to detect the cardiotoxicity of chemicals and their bio-transformation products. The novel platform will enable regulators and industry to identify, quantify and prevent cardiotoxic co-exposures to industrial chemicals and pharmaceuticals in a cost-effective way. ALTERNATIVE will particularly focus on cardiotoxic effects on older people, which is of high relevance in view of the ageing EU population and the high spread of cardiovascular diseases.The platform will consist of a three-dimensional tissue engineering in-vitro model mimicking the human cardiac tissue, coupled with a reliable, high-throughput monitoring system based on multi-omics analyses, and integrated into a Machine Learning (ML) risk assessment tool. In addition, ALTERNATIVE will modify the tissue model to reproduce the aged myocardial tissue and elucidate the adverse effects of chemicals on older people. ALTERNATIVE?s proof-of-concept validation will be performed on well-known mixtures of pollutants, affecting different environmental compartments, and selected via epidemiological, toxicological and modelling expertise.ALTERNATIVE will also provide systematic reviews of high-quality epidemiological studies to support integrated in vitro and in silico data, giving a more robust basis for regulatory decisions.The ALTERNATIVE platform will be an innovative tool for complying with the current regulation associated with the assessment of chemical compounds. It will be a new instrument to evaluate unpredictable toxicity due to synergistic effects of different chemicals, additionally worsened by the human ageing process.By introducing an in vitro cardiac system and ML models, ALTERNATIVE will provide a platform able to refine, reduce and replace the need for animal testing, providing close-to-real scenario information on toxicity and achieving a significant reduction of the associated direct and indirect costs. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesclinical medicinecardiologycardiovascular diseasesnatural sciencescomputer and information sciencesartificial intelligencemachine learning Programme(s) H2020-EU.3.5. - SOCIETAL CHALLENGES - Climate action, Environment, Resource Efficiency and Raw Materials Main Programme Topic(s) LC-GD-8-2-2020 - Fostering regulatory science to address combined exposures to industrial chemicals and pharmaceuticals: from science to evidence-based policies Call for proposal H2020-LC-GD-2020 See other projects for this call Sub call H2020-LC-GD-2020-3 Funding Scheme RIA - Research and Innovation action Coordinator POLITECNICO DI TORINO Net EU contribution € 592 300,00 Address Corso duca degli abruzzi 24 10129 Torino Italy See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (10) Sort alphabetically Sort by Net EU contribution Expand all Collapse all SCIENSANO Belgium Net EU contribution € 460 051,00 Address Juliette wytsmanstraat 14 1050 Elsene See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SI ES TI EOOD Bulgaria Net EU contribution € 198 750,00 Address Al. stamobliysky 18 6500 Svilengrad See on map Region Югозападна и Южна централна България Южен централен Хасково Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ELVESYS France Net EU contribution € 473 218,75 Address 172 rue de charonne b2 2 eme etage 75011 Paris See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CONSIGLIO NAZIONALE DELLE RICERCHE Italy Net EU contribution € 569 500,00 Address Piazzale aldo moro 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FUNDACIO EURECAT Spain Net EU contribution € 1 439 437,50 Address Avenida universitat autonoma 23 08290 Cerdanyola del valles (barcelona) See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EURESCOM-EUROPEAN INSTITUTE FOR RESEARCH AND STRATEGIC STUDIES IN TELECOMMUNICATIONS GMBH Germany Net EU contribution € 468 250,00 Address Wieblinger weg 19/4 69123 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Italy Net EU contribution € 386 750,00 Address Via mario negri 2 20156 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 IVTECH SRL Italy Net EU contribution € 306 750,00 Address Via di bagnaia 55054 Massarosa See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Toscana Lucca Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITEIT UTRECHT Netherlands Net EU contribution € 362 500,00 Address Heidelberglaan 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MEDIZINISCHE UNIVERSITAT INNSBRUCK Austria Net EU contribution € 242 250,00 Address Christoph probst platz 1 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00