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environmentAL Toxicity chEmical mixtuRes through aN innovative platform based on aged cardiac tissue model

Project description

Environmental chemical exposure weighs heavy on the heart

Toxic chemicals are omnipresent in the environment. From pesticides to drug traces in water, soil, air and living organisms, people are continuously exposed to a huge amount and variety of potentially toxic substances. At the same time, a growing occurrence of cardiovascular diseases has been observed, leading to the hypothesis that the two phenomena are related. To address this issue, the EU-funded ALTERNATIVE project will develop a platform that enables the identification, quantification and prevention of cardiotoxic co-exposures to industrial chemicals and pharmaceuticals. The platform will consist of a three-dimensional in vitro model mimicking the human cardiac tissue, coupled with a reliable, high-throughput monitoring system based on multi-omics analyses and integrated into a machine-learning risk assessment tool.

Call for proposal

H2020-LC-GD-2020-3
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Coordinator

POLITECNICO DI TORINO
Address
Corso Duca Degli Abruzzi 24
10129 Torino
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 592 300

Participants (10)

SCIENSANO
Belgium
EU contribution
€ 460 051
Address
Juliette Wytsmanstraat 14
1050 Elsene
Activity type
Research Organisations
SI ES TI EOOD
Bulgaria
EU contribution
€ 198 750
Address
Al. Stamobliysky 18
6500 Svilengrad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELVESYS
France
EU contribution
€ 473 218,75
Address
172 Rue De Charonne B2 2 Eme Etage
75011 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 569 500
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
FUNDACIO EURECAT
Spain
EU contribution
€ 1 439 437,50
Address
Avenida Universitat Autonoma 23
08290 Cerdanyola Del Valles (Barcelona)
Activity type
Research Organisations
EURESCOM-EUROPEAN INSTITUTE FOR RESEARCH AND STRATEGIC STUDIES IN TELECOMMUNICATIONS GMBH
Germany
EU contribution
€ 468 250
Address
Wieblinger Weg 19/4
69123 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 386 750
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
IVTECH SRL
Italy
EU contribution
€ 306 750
Address
Via Di Bagnaia
55054 Massarosa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 362 500
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 242 250
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments