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environmentAL Toxicity chEmical mixtuRes through aN innovative platform based on aged cardiac tissue model

Description du projet

DEENESFRITPL

L’exposition aux substances chimiques environnementales pèse gros sur le cœur

Les substances chimiques toxiques sont omniprésentes dans l’environnement. Des pesticides aux traces de médicaments dans l’eau, le sol, l’air et les organismes vivants, les populations sont continuellement exposées à une quantité et une variété immenses de substances potentiellement toxiques. En parallèle, on assiste à une incidence accrue des maladies cardiovasculaires, ce qui donne à penser qu’il existe une corrélation entre ces deux phénomènes. Afin de tirer au clair cette hypothèse, le projet ALTERNATIVE, financé par l’UE, mettra au point une plateforme permettant d’identifier, de quantifier et de prévenir les co-expositions cardiotoxiques aux substances chimiques et pharmaceutiques industrielles. La plateforme consistera en un modèle in vitro tridimensionnel qui imite le tissu cardiaque humain, associé à un système de surveillance fiable à haut débit reposant sur des analyses multi-omiques et intégré à un outil d’évaluation des risques par apprentissage automatique.

Objectif

ALTERNATIVE will develop an innovative platform able to detect the cardiotoxicity of chemicals and their bio-transformation products. The novel platform will enable regulators and industry to identify, quantify and prevent cardiotoxic co-exposures to industrial chemicals and pharmaceuticals in a cost-effective way. ALTERNATIVE will particularly focus on cardiotoxic effects on older people, which is of high relevance in view of the ageing EU population and the high spread of cardiovascular diseases.
The platform will consist of a three-dimensional tissue engineering in-vitro model mimicking the human cardiac tissue, coupled with a reliable, high-throughput monitoring system based on multi-omics analyses, and integrated into a Machine Learning (ML) risk assessment tool. In addition, ALTERNATIVE will modify the tissue model to reproduce the aged myocardial tissue and elucidate the adverse effects of chemicals on older people. ALTERNATIVE?s proof-of-concept validation will be performed on well-known mixtures of pollutants, affecting different environmental compartments, and selected via epidemiological, toxicological and modelling expertise.
ALTERNATIVE will also provide systematic reviews of high-quality epidemiological studies to support integrated in vitro and in silico data, giving a more robust basis for regulatory decisions.
The ALTERNATIVE platform will be an innovative tool for complying with the current regulation associated with the assessment of chemical compounds. It will be a new instrument to evaluate unpredictable toxicity due to synergistic effects of different chemicals, additionally worsened by the human ageing process.
By introducing an in vitro cardiac system and ML models, ALTERNATIVE will provide a platform able to refine, reduce and replace the need for animal testing, providing close-to-real scenario information on toxicity and achieving a significant reduction of the associated direct and indirect costs.

Champ scientifique

Programme(s)

Thème(s)

Appel à propositions

H2020-LC-GD-2020

Voir d’autres projets de cet appel

Sous appel

H2020-LC-GD-2020-3

Régime de financement

RIA - Research and Innovation action

Coordinateur

POLITECNICO DI TORINO
Contribution nette de l'UE
€ 592 300,00
Adresse
Corso duca degli abruzzi 24
10129 Torino
Italie

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Région
Nord-Ovest Piemonte Torino
Type d’activité
Higher or Secondary Education Establishments
Liens
Autres sources de financement
€ 0,00

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Dernière mise à jour: 17 Novembre 2022

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Permalink: https://cordis.europa.eu/project/id/101037090/fr

European Union, 2023