Description du projet
Le rôle du cerveau dans la création des rêves
Les rêves, comme l’imaginaire, semblent très réels pour nous car nos cerveaux sont responsables de leur création. Le projet Dreamscape, financé par l’UE, entend trouver les réponses au rôle du cerveau dans la création des rêves. Il examinera un ensemble de potentialités électroencéphalographiques qui émergent durant le sommeil et l’éveil pour démontrer si ces potentialités du cerveau génèrent les rêves, et comment, le cas échéant. Pour obtenir les résultats qu’il cherche, Dreamscape combinera plusieurs approches expérimentales innovantes, y compris des manipulations pharmacologiques et des analyses de mouvement. Les conclusions nous permettront mieux comprendre comment et pourquoi nous rêvons, contribueront aux domaines des neurosciences, de la neuropsychiatrie et de la conscience, et pourraient mener au développement de solutions pratiques pour les personnes qui luttent contre des troubles du sommeil.
Objectif
Why and how do we dream? Although this question has fascinated humankind since the earliest ages, it remains largely unanswered. Each night, when we fall asleep, we progressively disengage from the external world until we cease to perceive it and to act upon it. Despite this sensorimotor disconnection, in our dreams we perceive and act, and although we do so in a purely imaginary world, our experiences bear so much resemblance with the real world that we almost invariably take them for real. How does the brain create such a real-world analogue, and why? Based on my previous work, in which I identified a neural signature of dreaming, I propose to answer this question by studying a set of electroencephalographic (EEG) potentials, which not only occur spontaneously during sleep, but in a similar form also during wakefulness, as part of reactions to unexpected environmental stimuli. The overarching objective of this proposal is to understand the precise role of these brain potentials in the generation of dreams. Specifically, I will 1) provide a systematic characterization of these potentials in the sleeping and waking brain, 2) clarify their relation to arousal systems, 3) assess how they relate to sensory and motor features of dreams and 4) manipulate them to causally affect dreams. To achieve these aims, I will employ a unique combination of cutting-edge experimental approaches, including 256-channel-high-density EEG sleep recordings combined with controlled sensory stimulations, serial awakening paradigms, pharmacological manipulations, closed-loop acoustic slow wave modulation and movement analyses in neurological patients who act out their dreams. These projects will contribute to the basic understanding of how and why we dream, with implications for the fields of consciousness, neuroscience and neuropsychiatry. They will also provide technological and pharmacological tools to manipulate sleep and dreams, with clinical relevance for patients with sleep disorders.
Champ scientifique
Mots‑clés
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Thème(s)
Régime de financement
HORIZON-ERC - HORIZON ERC GrantsInstitution d’accueil
1011 JV AMSTERDAM
Pays-Bas