Deciphering Gene Regulatory Networks governing Mammalian Sex Determination

Informazioni relative al progetto

EnhanceSex

ID dell’accordo di sovvenzione: 101039928

DOI

10.3030/101039928

Data della firma CE 17 Febbraio 2022

Data di avvio 1 Aprile 2022

Data di completamento 31 Marzo 2027

Finanziato da

• European Research Council (ERC)

Costo totale

€ 1 651 868,00

Contributo UE

€ 1 651 868,00

Coordinato da

BAR ILAN UNIVERSITY
Israel

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

Data Management Plan

The EnhanceSex project will generate data both in the form of experimental results and metadata arising from RNA sequencing ATACSeq ChIPSeq and PCHiC including its computational analysis Experimental results will be openly available by publishing in scientific journals via the openaccess option All sequencing and experimental data will be stored and backed up in the lab servers and online cloud using Dropbox unlimited business account The sequencing data will be deposited at GEO public repository and accession numbers made available via scientific publishing in the above said openaccess publications Scripts and pipelines will be made available using open access publication and on the Gonen lab website at wwwgonenlabcom

Pubblicazioni

Peer reviewed articles (5)

Two redundant transcription factor binding sites in a single enhancer are essential for mammalian sex determination

Autori: Meshi Ridnik, Elisheva Abberbock, Veronica Alipov, Shelly Ziv Lhermann, Shoham Kaufman, Maor Lubman, Francis Poulat, Nitzan Gonen*
Pubblicato in: Nucleic Acids Research, 2024, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkae178

Transposable elements acquire time- and sex-specific transcriptional and epigenetic signatures along mouse fetal gonad development

Autori: Stévant I., Gonen N.*, Poulat F.*
Pubblicato in: Front Cell Dev Biol, 2024, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2023.1327410

Epigenetic Aging of Mammalian Gametes

Autori: Klustein M.*, Gonen N.*
Pubblicato in: Molecular Reproduction and Development, 2023, ISSN 1040-452X
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrd.23717

"Towards a ""testis in a dish"": generation of mouse testicular organoids that recapitulate testis structure and expression profiles"

Autori: Stopel A., Lev C., Dahari S., Adibi O., Armon L., Gonen N.
Pubblicato in: International Journal of Biological Sciences, 2024, ISSN 1449-2288
Editore: International Journal of Biological Sciences
DOI: 10.7150/ijbs.89480

In vitro cellular reprogramming to model gonad development and its disorders

Autori: Gonen, Nitzan; Eozenou, Caroline; Mitter, Richard; Elzaiat, Maëva; Stévant, Isabelle; Aviram, Rona; Bernardo, Andreia Sofia; Chervova, Almira; Wankanit, Somboon; Frachon, Emmanuel; Commere, Pierre-Henri; Brailly-Tabard, Sylvie; Valon, Léo; Barrio Cano, Laura; Levayer, Romain; Mazen, Inas; Gobaa, Samy; Smith, James C.; McElreavey, Kenneth; Lovell-Badge, Robin; Bashamboo, Anu
Pubblicato in: Science Advances, 2023, ISSN 2375-2548
Editore: Science
DOI: 10.25418/crick.21841020.v1