Adaptive Multi-Drug Infusion Control System for General Anesthesia in Major Surgery

Project Information

AMICAS

Grant agreement ID: 101043225

DOI

10.3030/101043225

EC signature date 18 July 2022

Start date 1 October 2022

End date 30 September 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 927 325,00

EU contribution

€ 1 927 325,00

Coordinated by

UNIVERSITEIT GENT
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Conference proceedings (16)

Uncertainty Minimization and Feasibility Study for Managing the Complex and Interacting Anesthesia-Hemodynamic System

Author(s): Ghita, Mihaela; Copot, Dana; Birs, Isabela R.; Muresan, Cristina I.; Keyser, Robin De; Neckebroek, Martine; Struys, Michel M.R.F.; Ionescu, Clara M.
Published in: IEEE 61st Conference on Decision and Control (CDC), 2022, ISSN 0743-1546
Publisher: IEEE
DOI: 10.1109/cdc51059.2022.9992350

A compact fractional-order model for hypnosis in general anesthesia

Author(s): Marcian Mihai , Isabela Roxana Birs, Erwin Hegedus , Dana Copot, Robain De Keyser, Clara-Mihaela Ionescu, Cristina Muresan and Martine Neckebroek
Published in: 12th IFAC Conference on Fractional Differentiation and its Application (ICFDA), 2024, ISSN 2405-8963
Publisher: ELSEVIER
DOI: 10.1016/j.ifacol.2024.08.166

Analysis and Preliminary Results of a Feedback-Feedforward Controller for Depth of Anesthesia

Author(s): Erwin Hegedus, Marcian D. Mihai, Isabela R. Birs, Hamed Farbakhsh, Erhan Yumuk, Dana Copot, Eva H. Dulf, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Published in: IFAC-PapersOnLine, Issue 58, 2024, ISSN 2405-8963
Publisher: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.037

A Compartmental Modelling Framework for Drug Distribution in Lean and Obese Patients in Long-Term General Anesthesia^*

Author(s): Amani R. Ynineb, Erhan Yumuk, Hamed Farbakhsh, Ghada Ben Othman, Dana Copot, Isabela R. Birs, Cristina I. Muresan, Robin De Keyser, Samir Ladaci, Clara M. Ionescu, Martine Neckebroek
Published in: 2024 European Control Conference (ECC), 2024
Publisher: IEEE
DOI: 10.23919/ECC64448.2024.10590971

Uncertainty and its Effect on Optimal Multidrug Control of Hemodynamic Variables

Author(s): Teodora Popescu, Isabela R. Birs, Ghada Ben Othman, Erhan Yumuk, Marcian Mihai, Erwin Hegedus, Dana Copot, Robin De Keyser, Clara M. Ionescu, Cristina I. Muresan
Published in: 2024 American Control Conference (ACC), 2024
Publisher: IEEE
DOI: 10.23919/ACC60939.2024.10644844

PID control of data-driven patient response with fixed ratio co-administration of drugs for depth of hypnosis

Author(s): Clara M. Ionescu, Hamed Farbakhsh, Cristina Muresan, Robin De Keyser, Erhan Yumuk, Ghada Ben Othman, Amani Rayene Ynineb, Isabela Birs, Dana Copot, Martine Neckebroek
Published in: IFAC-PapersOnLine, Issue 58, 2024, ISSN 2405-8963
Publisher: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.038

An adaptive control structure to mitigate lack of feasibility in systems with poor identifiability. Case Study on General Anesthesia

Author(s): Clara M. Ionescu, Robin De Keyser, Erhan Yumuk, Dana Copot, Martine Neckebroek
Published in: IFAC-PapersOnLine, Issue 58, 2024, ISSN 2405-8963
Publisher: Elsevier BV
DOI: 10.1016/J.IFACOL.2024.11.039

Comparative Analysis of Pharmacokinetic-Pharmacodynamic Models for Propofol and Remifentanil Using Model Predictive Control

Author(s): A. R. Ynineb, H. Farbakhsh, G. Ben Othman, Y. Wahlquist, I. R. Birs, E. Yumuk, C. I. Muresan, R. De Keyser, D. Copot, C. M. Ionescu, M. Neckebroek
Published in: 2024 European Control Conference (ECC), 2024
Publisher: IEEE
DOI: 10.23919/ECC64448.2024.10590766

A fractional order impedance model for heterogeneous drug distribution in obese patients during general anesthesia

Author(s): Amani Rayene Ynineb, Erhan Yumuk, Hamed Farbakhs , Ghada Ben Othman , Dana Copot, Isabela Roxana Birs, Cristina Muresan, Robain De Keyser , Samir Ladaci, Clara-Mihaela Ionescu and Martine Neckebroek.
Published in: 12th IFAC Conference on Fractional Differentiation and its Application (ICFDA), 2024, ISSN 2405-8963
Publisher: ELSEVIER
DOI: 10.1016/j.ifacol.2024.08.167

Model predictive control of hemodynamics during intravenous general anesthesia

Author(s): Hamed Farbakhsh, Erhan Yumuk, Ghada Ben Othman, Robin De Keyser, Dana Copot, Isabela Birs, Clara M. Ionescu
Published in: 2023 27th International Conference on System Theory, Control and Computing (ICSTCC), 2023, ISSN 2473-5698
Publisher: IEEE
DOI: 10.1109/icstcc59206.2023.10308441

Modelling of Blood Loss Influence on Propofol Concentrations and Anesthetic States in Critical Responses *

Author(s): Mihaela Ghita, Dana Copot, Isabela Birs, Cristina Muresan, Martine Neckebroek, Clara Ionescu
Published in: 2023 American Control Conference (ACC), 2024, ISSN 0743-1619
Publisher: IEEE
DOI: 10.23919/ACC55779.2023.10156356

Minimizing Epistemic Uncertainty for Predictive Control of General Anesthesia

Author(s): Clara M. Ionescu, Robin De Keyser, Dana Copot, Erhan Yumuk, Isabela R. Birs, Erwin Hegedus, Cristina I. Muresan, Martine Neckebroek
Published in: IFAC-PapersOnLine, Issue 58, 2024, ISSN 2405-8963
Publisher: Elsevier BV
DOI: 10.1016/J.IFACOL.2024.11.086

A Decoupled Fractional Order Control Strategy to Increase Patient Safety During Anesthesia-Hemodynamic Interactions

Author(s): Erwin Hegedus, Marcian D. Mihai, Isabela R. Birs, Hamed Farbakhsh, Erhan Yumuk, Dana Copot, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Published in: 2024 European Control Conference (ECC), 2024
Publisher: IEEE
DOI: 10.23919/ECC64448.2024.10591046

Inducing Anaesthesia via Exact Feedback Linearization control

Author(s): Paul A. Pintea, Eva H. Dulf, Cristina I. Muresan, Clara M. Ionescu
Published in: IFAC-PapersOnLine, Issue 58, 2024, ISSN 2405-8963
Publisher: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.069

Fractional Order PID Control of Propofol Dosage and Optimization in Lean and Obese Patients

Author(s): Amani R. Ynineb, Marcian-David Mihai, Erhan Yumuk, Hamed Farbakhsh, Ghada Ben Othman, Robin De Keyser, Cristina Muresan, Isabela Birs, Dana Copot, Clara M. Ionescu
Published in: IFAC-PapersOnLine, Issue 58, 2024, ISSN 2405-8963
Publisher: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.039

First-Hand Design of a Fractional order PID for Controlling the Depth of Hypnosis during Induction

Author(s): Marcian Mihai, Isabela Birs, Hegedus Erwin, Dana Copot, Martine Neckebroek, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Published in: IFAC-PapersOnLine, Issue 58, 2024, ISSN 2405-8963
Publisher: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.032

Peer reviewed articles (8)

A Novel Decentralized–Decoupled Fractional-Order Control Strategy for Complete Anesthesia–Hemodynamic Stabilization in Patients Undergoing Surgical Procedures

Author(s): Erwin T. Hegedüs, Isabela R. Birs, Clara M. Ionescu, Cristina I. Muresan
Published in: Fractal and Fractional, Issue 8, 2024, ISSN 2504-3110
Publisher: MDPI AG
DOI: 10.3390/FRACTALFRACT8110623

Model Extraction From Clinical Data Subject to Large Uncertainties and Poor Identifiability

Author(s): Clara M. Ionescu, Robin De Keyser, Dana Copot, Erhan Yumuk, Amani Ynineb, Ghada Ben Othman, Martine Neckebroek
Published in: IEEE Control Systems Letters, Issue 8, 2024, ISSN 2475-1456
Publisher: IEEE
DOI: 10.1109/LCSYS.2024.3402942

Modeling, analysis and experimental observations of fat volume properties in compartmental models for drug pharmacokinetics

Author(s): Amani R. Ynineb; Bouchra Khoumeri; Erhan Yumuk; Bora Ayvaz; Ghada Ben Othman; Clara M. Ionescu; Dana Copot
Published in: Annual Reviews in Control, Issue 60, 2025, ISSN 1872-9088
Publisher: Elsevier
DOI: 10.1016/J.ARCONTROL.2025.100996

Parametric Modeling and Deep Learning for Enhancing Pain Assessment in Postanesthesia

Author(s): Mihaela Ghita, Isabela R. Birs, Dana Copot, Cristina I. Muresan, Martine Neckebroek, Clara M. Ionescu
Published in: IEEE Transactions on Biomedical Engineering, Issue 70, 2024, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TBME.2023.3274541

Fractional-Order Modeling of the Depth of Analgesia as Reference Model for Control Purposes

Author(s): Cristina I. Muresan, Erwin T. Hegedüs, Marcian D. Mihai, Ghada Ben Othman, Isabela Birs, Dana Copot, Eva Henrietta Dulf, Robin De Keyser, Clara M. Ionescu, Martine Neckebroek
Published in: Fractal and Fractional, Issue 8, 2024, ISSN 2504-3110
Publisher: MDPI AG
DOI: 10.3390/fractalfract8090539

Biomedical Signal Processing and Control

Author(s): Mihaela Ghita, Isabela R. Birs, Dana Copot, Cristina I. Muresan, Clara M. Ionescu
Published in: Biomedical Signal Processing and Control, Issue 83, 2023, ISSN 1746-8094
Publisher: Elsevier BV
DOI: 10.1016/J.BSPC.2023.104678

Sensors

Author(s): Clara M. Ionescu; Dana Copot; Erhan Yumuk; Robin De Keyser; Cristina Muresan; Isabela Roxana Birs; Ghada Ben Othman; Hamed Farbakhsh; Amani R. Ynineb; Martine Neckebroek
Published in: Sensors, Vol 24, Iss 7, p 2031 (2024), 2024, ISSN 1424-8220
Publisher: MDPI
DOI: 10.3390/S24072031

Journal of Process Control

Author(s): Erhan Yumuk; Dana Copot; Clara M. Ionescu; Martine Neckebroek
Published in: JOURNAL OF PROCESS CONTROL, 2024, ISSN 0959-1524
Publisher: ELSEVIER SCI LTD
DOI: 10.1016/j.jprocont.2024.103243