Adaptive Multi-Drug Infusion Control System for General Anesthesia in Major Surgery

Informacje na temat projektu

AMICAS

Identyfikator umowy o grant: 101043225

DOI

10.3030/101043225

Data podpisania przez KE 18 Lipca 2022

Data rozpoczęcia 1 Października 2022

Data zakończenia 30 Września 2027

Finansowanie w ramach

• European Research Council (ERC)

Koszt całkowity

€ 1 927 325,00

Wkład UE

€ 1 927 325,00

Koordynowany przez

UNIVERSITEIT GENT
Belgium

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (17)

Scientific Reports

Autorzy: Ynineb, Amani Rayene; Yumuk, Erhan; Copot, Dana; Ayvaz, Bora; Khoumeri, Bouchra; Ben Othman, Ghada; n D. Mihai, Marcian; Birs, Isabela Roxana; I. Muresan, Cristina; Ionescu, Clara
Opublikowane w: Scientific Reports, Numer 15, 2025, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/S41598-025-10172-1

A Novel Decentralized–Decoupled Fractional-Order Control Strategy for Complete Anesthesia–Hemodynamic Stabilization in Patients Undergoing Surgical Procedures

Autorzy: Erwin T. Hegedüs, Isabela R. Birs, Clara M. Ionescu, Cristina I. Muresan
Opublikowane w: Fractal and Fractional, Numer 8, 2024, ISSN 2504-3110
Wydawca: MDPI AG
DOI: 10.3390/FRACTALFRACT8110623

Journal of Advanced Research

Autorzy: Mihai, Marcian; Birs, Isabela Roxana; Hegedus, Erwin; Ynineb, Amani Rayene; Copot, Dana; De Keyser, Robain; Ionescu, Clara; Ladaci, Samir; Muresan, Cristina I.; Neckebroek, Martine
Opublikowane w: Journal of Advanced Research, Numer 78, 2025, ISSN 2090-1232
Wydawca: Elsevier
DOI: 10.1016/J.JARE.2025.03.053

Journal of Pharmacokinetics and Pharmacodynamics

Autorzy: Yumuk, Erhan; Ionescu, Clara
Opublikowane w: Journal of Pharmacokinetics and Pharmacodynamics, Numer 12, 2026, ISSN 1567-567X
Wydawca: Springer
DOI: 10.1007/S10928-026-10026-X

Model Extraction From Clinical Data Subject to Large Uncertainties and Poor Identifiability

Autorzy: Clara M. Ionescu, Robin De Keyser, Dana Copot, Erhan Yumuk, Amani Ynineb, Ghada Ben Othman, Martine Neckebroek
Opublikowane w: IEEE Control Systems Letters, Numer 8, 2024, ISSN 2475-1456
Wydawca: IEEE
DOI: 10.1109/LCSYS.2024.3402942

Modeling, analysis and experimental observations of fat volume properties in compartmental models for drug pharmacokinetics

Autorzy: Amani R. Ynineb; Bouchra Khoumeri; Erhan Yumuk; Bora Ayvaz; Ghada Ben Othman; Clara M. Ionescu; Dana Copot
Opublikowane w: Annual Reviews in Control, Numer 60, 2025, ISSN 1872-9088
Wydawca: Elsevier
DOI: 10.1016/J.ARCONTROL.2025.100996

Pharmacokinetic modelling during long-term anesthesia: minimizing the gap

Autorzy: Amani Rayene Ynineb, Erhan Yumuk, Dana Copot, Ghada Ben Othman, Hamed Farbakhsh, Isabela Roxana Birs, Robain De Keyser, Samir Ladaci, Cristina I. Muresan, Martine Neckebroek, et al.
Opublikowane w: Journal of Advanced Research, Numer 82, p.535-561, 2026, ISSN 2090-1224
Wydawca: Elsevier
DOI: 10.1016/J.JARE.2025.06.047

Parametric Modeling and Deep Learning for Enhancing Pain Assessment in Postanesthesia

Autorzy: Mihaela Ghita, Isabela R. Birs, Dana Copot, Cristina I. Muresan, Martine Neckebroek, Clara M. Ionescu
Opublikowane w: IEEE Transactions on Biomedical Engineering, Numer 70, 2024, ISSN 0018-9294
Wydawca: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TBME.2023.3274541

Physiological framework for non-invasive detection and objective nociception activity in communicative patients: a pilot case study

Autorzy: Ghada Ben Othman, Dana Copot, Bora Ayvaz, Robin De Keyser, Clara M. Ionescu
Opublikowane w: Frontiers in Physiology, Numer 16, 2026, ISSN 1664-042X
Wydawca: Frontiers Media SA
DOI: 10.3389/FPHYS.2025.1704303

Fractional-Order Modeling of the Depth of Analgesia as Reference Model for Control Purposes

Autorzy: Cristina I. Muresan, Erwin T. Hegedüs, Marcian D. Mihai, Ghada Ben Othman, Isabela Birs, Dana Copot, Eva Henrietta Dulf, Robin De Keyser, Clara M. Ionescu, Martine Neckebroek
Opublikowane w: Fractal and Fractional, Numer 8, 2024, ISSN 2504-3110
Wydawca: MDPI AG
DOI: 10.3390/fractalfract8090539

Biomedical Signal Processing and Control

Autorzy: Mihaela Ghita, Isabela R. Birs, Dana Copot, Cristina I. Muresan, Clara M. Ionescu
Opublikowane w: Biomedical Signal Processing and Control, Numer 83, 2023, ISSN 1746-8094
Wydawca: Elsevier BV
DOI: 10.1016/J.BSPC.2023.104678

Biomedical Signal Processing and Control

Autorzy: Bouchra Khoumeri; Dana Copot; Amani R. Ynineb; Bora Ayvaz; Ghada Ben Othman; Erhan Yumuk; Clara M. Ionescu
Opublikowane w: Biomedical Signal Processing and Control, Numer 109764, 2026, ISSN 1746-8094
Wydawca: Elsevier BV
DOI: 10.1016/J.BSPC.2026.109764

Information-Gated Truncated Unscented Kalman Filtering for Latent-State Estimation Under Poor Identifiability

Autorzy: Bouchra Khoumeri, Erwin Hegedus, Amani Ynineb, Bora Ayvaz, Dana Copot, Clara M. Ionescu
Opublikowane w: IEEE Control Systems Letters, Numer 10, 2026, ISSN 2475-1456
Wydawca: IEEE
DOI: 10.1109/LCSYS.2026.3715418

Sensors

Autorzy: Clara M. Ionescu; Dana Copot; Erhan Yumuk; Robin De Keyser; Cristina Muresan; Isabela Roxana Birs; Ghada Ben Othman; Hamed Farbakhsh; Amani R. Ynineb; Martine Neckebroek
Opublikowane w: Sensors, Vol 24, Iss 7, p 2031 (2024), 2024, ISSN 1424-8220
Wydawca: MDPI
DOI: 10.3390/S24072031

Journal of Process Control

Autorzy: Erhan Yumuk; Dana Copot; Clara M. Ionescu; Martine Neckebroek
Opublikowane w: JOURNAL OF PROCESS CONTROL, 2024, ISSN 0959-1524
Wydawca: ELSEVIER SCI LTD
DOI: 10.1016/j.jprocont.2024.103243

Systemic fragility in European total intravenous anesthesia delivery and opportunities for resilient real-time decision support

Autorzy: Clara Ionescu, Erhan Yumuk, Michele Schiavo, Antonio Visioli, Massimiliano Paltenghi, Nicola Latronico, Bob Aubouin Pairault, Mirko Fiacchini, Kaouther Moussa, Cristina Muresan, Isabela Birs, Eva Dulf, Teodora Mocan, Lucian Mocan, Robert Szabo, Dana Copot
Opublikowane w: Communications Medicine, Numer 6, 2026, ISSN 2730-664X
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S43856-026-01833-X

Event-based control of postoperative analgesia using physiological nociception signals

Autorzy: Bora Ayvaz, Ghada Ben Othman, Erhan Yumuk, Dana Copot, Clara M. Ionescu
Opublikowane w: Biomedical Signal Processing and Control, Numer 126, 2026, ISSN 1746-8094
Wydawca: Elsevier BV
DOI: 10.1016/J.BSPC.2026.110867

Conference proceedings (16)

Uncertainty Minimization and Feasibility Study for Managing the Complex and Interacting Anesthesia-Hemodynamic System

Autorzy: Ghita, Mihaela; Copot, Dana; Birs, Isabela R.; Muresan, Cristina I.; Keyser, Robin De; Neckebroek, Martine; Struys, Michel M.R.F.; Ionescu, Clara M.
Opublikowane w: IEEE 61st Conference on Decision and Control (CDC), 2022, ISSN 0743-1546
Wydawca: IEEE
DOI: 10.1109/cdc51059.2022.9992350

A compact fractional-order model for hypnosis in general anesthesia

Autorzy: Marcian Mihai , Isabela Roxana Birs, Erwin Hegedus , Dana Copot, Robain De Keyser, Clara-Mihaela Ionescu, Cristina Muresan and Martine Neckebroek
Opublikowane w: 12th IFAC Conference on Fractional Differentiation and its Application (ICFDA), 2024, ISSN 2405-8963
Wydawca: ELSEVIER
DOI: 10.1016/j.ifacol.2024.08.166

Analysis and Preliminary Results of a Feedback-Feedforward Controller for Depth of Anesthesia

Autorzy: Erwin Hegedus, Marcian D. Mihai, Isabela R. Birs, Hamed Farbakhsh, Erhan Yumuk, Dana Copot, Eva H. Dulf, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Opublikowane w: IFAC-PapersOnLine, Numer 58, 2024, ISSN 2405-8963
Wydawca: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.037

A Compartmental Modelling Framework for Drug Distribution in Lean and Obese Patients in Long-Term General Anesthesia^*

Autorzy: Amani R. Ynineb, Erhan Yumuk, Hamed Farbakhsh, Ghada Ben Othman, Dana Copot, Isabela R. Birs, Cristina I. Muresan, Robin De Keyser, Samir Ladaci, Clara M. Ionescu, Martine Neckebroek
Opublikowane w: 2024 European Control Conference (ECC), 2024
Wydawca: IEEE
DOI: 10.23919/ECC64448.2024.10590971

Uncertainty and its Effect on Optimal Multidrug Control of Hemodynamic Variables

Autorzy: Teodora Popescu, Isabela R. Birs, Ghada Ben Othman, Erhan Yumuk, Marcian Mihai, Erwin Hegedus, Dana Copot, Robin De Keyser, Clara M. Ionescu, Cristina I. Muresan
Opublikowane w: 2024 American Control Conference (ACC), 2024
Wydawca: IEEE
DOI: 10.23919/ACC60939.2024.10644844

PID control of data-driven patient response with fixed ratio co-administration of drugs for depth of hypnosis

Autorzy: Clara M. Ionescu, Hamed Farbakhsh, Cristina Muresan, Robin De Keyser, Erhan Yumuk, Ghada Ben Othman, Amani Rayene Ynineb, Isabela Birs, Dana Copot, Martine Neckebroek
Opublikowane w: IFAC-PapersOnLine, Numer 58, 2024, ISSN 2405-8963
Wydawca: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.038

An adaptive control structure to mitigate lack of feasibility in systems with poor identifiability. Case Study on General Anesthesia

Autorzy: Clara M. Ionescu, Robin De Keyser, Erhan Yumuk, Dana Copot, Martine Neckebroek
Opublikowane w: IFAC-PapersOnLine, Numer 58, 2024, ISSN 2405-8963
Wydawca: Elsevier BV
DOI: 10.1016/J.IFACOL.2024.11.039

Comparative Analysis of Pharmacokinetic-Pharmacodynamic Models for Propofol and Remifentanil Using Model Predictive Control

Autorzy: A. R. Ynineb, H. Farbakhsh, G. Ben Othman, Y. Wahlquist, I. R. Birs, E. Yumuk, C. I. Muresan, R. De Keyser, D. Copot, C. M. Ionescu, M. Neckebroek
Opublikowane w: 2024 European Control Conference (ECC), 2024
Wydawca: IEEE
DOI: 10.23919/ECC64448.2024.10590766

A fractional order impedance model for heterogeneous drug distribution in obese patients during general anesthesia

Autorzy: Amani Rayene Ynineb, Erhan Yumuk, Hamed Farbakhs , Ghada Ben Othman , Dana Copot, Isabela Roxana Birs, Cristina Muresan, Robain De Keyser , Samir Ladaci, Clara-Mihaela Ionescu and Martine Neckebroek.
Opublikowane w: 12th IFAC Conference on Fractional Differentiation and its Application (ICFDA), 2024, ISSN 2405-8963
Wydawca: ELSEVIER
DOI: 10.1016/j.ifacol.2024.08.167

Model predictive control of hemodynamics during intravenous general anesthesia

Autorzy: Hamed Farbakhsh, Erhan Yumuk, Ghada Ben Othman, Robin De Keyser, Dana Copot, Isabela Birs, Clara M. Ionescu
Opublikowane w: 2023 27th International Conference on System Theory, Control and Computing (ICSTCC), 2023, ISSN 2473-5698
Wydawca: IEEE
DOI: 10.1109/icstcc59206.2023.10308441

Modelling of Blood Loss Influence on Propofol Concentrations and Anesthetic States in Critical Responses *

Autorzy: Mihaela Ghita, Dana Copot, Isabela Birs, Cristina Muresan, Martine Neckebroek, Clara Ionescu
Opublikowane w: 2023 American Control Conference (ACC), 2024, ISSN 0743-1619
Wydawca: IEEE
DOI: 10.23919/ACC55779.2023.10156356

Minimizing Epistemic Uncertainty for Predictive Control of General Anesthesia

Autorzy: Clara M. Ionescu, Robin De Keyser, Dana Copot, Erhan Yumuk, Isabela R. Birs, Erwin Hegedus, Cristina I. Muresan, Martine Neckebroek
Opublikowane w: IFAC-PapersOnLine, Numer 58, 2024, ISSN 2405-8963
Wydawca: Elsevier BV
DOI: 10.1016/J.IFACOL.2024.11.086

A Decoupled Fractional Order Control Strategy to Increase Patient Safety During Anesthesia-Hemodynamic Interactions

Autorzy: Erwin Hegedus, Marcian D. Mihai, Isabela R. Birs, Hamed Farbakhsh, Erhan Yumuk, Dana Copot, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Opublikowane w: 2024 European Control Conference (ECC), 2024
Wydawca: IEEE
DOI: 10.23919/ECC64448.2024.10591046

Inducing Anaesthesia via Exact Feedback Linearization control

Autorzy: Paul A. Pintea, Eva H. Dulf, Cristina I. Muresan, Clara M. Ionescu
Opublikowane w: IFAC-PapersOnLine, Numer 58, 2024, ISSN 2405-8963
Wydawca: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.069

Fractional Order PID Control of Propofol Dosage and Optimization in Lean and Obese Patients

Autorzy: Amani R. Ynineb, Marcian-David Mihai, Erhan Yumuk, Hamed Farbakhsh, Ghada Ben Othman, Robin De Keyser, Cristina Muresan, Isabela Birs, Dana Copot, Clara M. Ionescu
Opublikowane w: IFAC-PapersOnLine, Numer 58, 2024, ISSN 2405-8963
Wydawca: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.039

First-Hand Design of a Fractional order PID for Controlling the Depth of Hypnosis during Induction

Autorzy: Marcian Mihai, Isabela Birs, Hegedus Erwin, Dana Copot, Martine Neckebroek, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Opublikowane w: IFAC-PapersOnLine, Numer 58, 2024, ISSN 2405-8963
Wydawca: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.032