Adaptive Multi-Drug Infusion Control System for General Anesthesia in Major Surgery

Información del proyecto

AMICAS

Identificador del acuerdo de subvención: 101043225

DOI

10.3030/101043225

Fecha de la firma de la CE 18 Julio 2022

Fecha de inicio 1 Octubre 2022

Fecha de finalización 30 Septiembre 2027

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 1 927 325,00

Aportación de la UE

€ 1 927 325,00

Coordinado por

UNIVERSITEIT GENT
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Conference proceedings (16)

Uncertainty Minimization and Feasibility Study for Managing the Complex and Interacting Anesthesia-Hemodynamic System

Autores: Ghita, Mihaela; Copot, Dana; Birs, Isabela R.; Muresan, Cristina I.; Keyser, Robin De; Neckebroek, Martine; Struys, Michel M.R.F.; Ionescu, Clara M.
Publicado en: IEEE 61st Conference on Decision and Control (CDC), 2022, ISSN 0743-1546
Editor: IEEE
DOI: 10.1109/cdc51059.2022.9992350

A compact fractional-order model for hypnosis in general anesthesia

Autores: Marcian Mihai , Isabela Roxana Birs, Erwin Hegedus , Dana Copot, Robain De Keyser, Clara-Mihaela Ionescu, Cristina Muresan and Martine Neckebroek
Publicado en: 12th IFAC Conference on Fractional Differentiation and its Application (ICFDA), 2024, ISSN 2405-8963
Editor: ELSEVIER
DOI: 10.1016/j.ifacol.2024.08.166

Analysis and Preliminary Results of a Feedback-Feedforward Controller for Depth of Anesthesia

Autores: Erwin Hegedus, Marcian D. Mihai, Isabela R. Birs, Hamed Farbakhsh, Erhan Yumuk, Dana Copot, Eva H. Dulf, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.037

A Compartmental Modelling Framework for Drug Distribution in Lean and Obese Patients in Long-Term General Anesthesia^*

Autores: Amani R. Ynineb, Erhan Yumuk, Hamed Farbakhsh, Ghada Ben Othman, Dana Copot, Isabela R. Birs, Cristina I. Muresan, Robin De Keyser, Samir Ladaci, Clara M. Ionescu, Martine Neckebroek
Publicado en: 2024 European Control Conference (ECC), 2024
Editor: IEEE
DOI: 10.23919/ECC64448.2024.10590971

Uncertainty and its Effect on Optimal Multidrug Control of Hemodynamic Variables

Autores: Teodora Popescu, Isabela R. Birs, Ghada Ben Othman, Erhan Yumuk, Marcian Mihai, Erwin Hegedus, Dana Copot, Robin De Keyser, Clara M. Ionescu, Cristina I. Muresan
Publicado en: 2024 American Control Conference (ACC), 2024
Editor: IEEE
DOI: 10.23919/ACC60939.2024.10644844

PID control of data-driven patient response with fixed ratio co-administration of drugs for depth of hypnosis

Autores: Clara M. Ionescu, Hamed Farbakhsh, Cristina Muresan, Robin De Keyser, Erhan Yumuk, Ghada Ben Othman, Amani Rayene Ynineb, Isabela Birs, Dana Copot, Martine Neckebroek
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.038

An adaptive control structure to mitigate lack of feasibility in systems with poor identifiability. Case Study on General Anesthesia

Autores: Clara M. Ionescu, Robin De Keyser, Erhan Yumuk, Dana Copot, Martine Neckebroek
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/J.IFACOL.2024.11.039

Comparative Analysis of Pharmacokinetic-Pharmacodynamic Models for Propofol and Remifentanil Using Model Predictive Control

Autores: A. R. Ynineb, H. Farbakhsh, G. Ben Othman, Y. Wahlquist, I. R. Birs, E. Yumuk, C. I. Muresan, R. De Keyser, D. Copot, C. M. Ionescu, M. Neckebroek
Publicado en: 2024 European Control Conference (ECC), 2024
Editor: IEEE
DOI: 10.23919/ECC64448.2024.10590766

A fractional order impedance model for heterogeneous drug distribution in obese patients during general anesthesia

Autores: Amani Rayene Ynineb, Erhan Yumuk, Hamed Farbakhs , Ghada Ben Othman , Dana Copot, Isabela Roxana Birs, Cristina Muresan, Robain De Keyser , Samir Ladaci, Clara-Mihaela Ionescu and Martine Neckebroek.
Publicado en: 12th IFAC Conference on Fractional Differentiation and its Application (ICFDA), 2024, ISSN 2405-8963
Editor: ELSEVIER
DOI: 10.1016/j.ifacol.2024.08.167

Model predictive control of hemodynamics during intravenous general anesthesia

Autores: Hamed Farbakhsh, Erhan Yumuk, Ghada Ben Othman, Robin De Keyser, Dana Copot, Isabela Birs, Clara M. Ionescu
Publicado en: 2023 27th International Conference on System Theory, Control and Computing (ICSTCC), 2023, ISSN 2473-5698
Editor: IEEE
DOI: 10.1109/icstcc59206.2023.10308441

Modelling of Blood Loss Influence on Propofol Concentrations and Anesthetic States in Critical Responses *

Autores: Mihaela Ghita, Dana Copot, Isabela Birs, Cristina Muresan, Martine Neckebroek, Clara Ionescu
Publicado en: 2023 American Control Conference (ACC), 2024, ISSN 0743-1619
Editor: IEEE
DOI: 10.23919/ACC55779.2023.10156356

Minimizing Epistemic Uncertainty for Predictive Control of General Anesthesia

Autores: Clara M. Ionescu, Robin De Keyser, Dana Copot, Erhan Yumuk, Isabela R. Birs, Erwin Hegedus, Cristina I. Muresan, Martine Neckebroek
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/J.IFACOL.2024.11.086

A Decoupled Fractional Order Control Strategy to Increase Patient Safety During Anesthesia-Hemodynamic Interactions

Autores: Erwin Hegedus, Marcian D. Mihai, Isabela R. Birs, Hamed Farbakhsh, Erhan Yumuk, Dana Copot, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Publicado en: 2024 European Control Conference (ECC), 2024
Editor: IEEE
DOI: 10.23919/ECC64448.2024.10591046

Inducing Anaesthesia via Exact Feedback Linearization control

Autores: Paul A. Pintea, Eva H. Dulf, Cristina I. Muresan, Clara M. Ionescu
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.069

Fractional Order PID Control of Propofol Dosage and Optimization in Lean and Obese Patients

Autores: Amani R. Ynineb, Marcian-David Mihai, Erhan Yumuk, Hamed Farbakhsh, Ghada Ben Othman, Robin De Keyser, Cristina Muresan, Isabela Birs, Dana Copot, Clara M. Ionescu
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.039

First-Hand Design of a Fractional order PID for Controlling the Depth of Hypnosis during Induction

Autores: Marcian Mihai, Isabela Birs, Hegedus Erwin, Dana Copot, Martine Neckebroek, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.032

Peer reviewed articles (8)

A Novel Decentralized–Decoupled Fractional-Order Control Strategy for Complete Anesthesia–Hemodynamic Stabilization in Patients Undergoing Surgical Procedures

Autores: Erwin T. Hegedüs, Isabela R. Birs, Clara M. Ionescu, Cristina I. Muresan
Publicado en: Fractal and Fractional, Edición 8, 2024, ISSN 2504-3110
Editor: MDPI AG
DOI: 10.3390/FRACTALFRACT8110623

Model Extraction From Clinical Data Subject to Large Uncertainties and Poor Identifiability

Autores: Clara M. Ionescu, Robin De Keyser, Dana Copot, Erhan Yumuk, Amani Ynineb, Ghada Ben Othman, Martine Neckebroek
Publicado en: IEEE Control Systems Letters, Edición 8, 2024, ISSN 2475-1456
Editor: IEEE
DOI: 10.1109/LCSYS.2024.3402942

Modeling, analysis and experimental observations of fat volume properties in compartmental models for drug pharmacokinetics

Autores: Amani R. Ynineb; Bouchra Khoumeri; Erhan Yumuk; Bora Ayvaz; Ghada Ben Othman; Clara M. Ionescu; Dana Copot
Publicado en: Annual Reviews in Control, Edición 60, 2025, ISSN 1872-9088
Editor: Elsevier
DOI: 10.1016/J.ARCONTROL.2025.100996

Parametric Modeling and Deep Learning for Enhancing Pain Assessment in Postanesthesia

Autores: Mihaela Ghita, Isabela R. Birs, Dana Copot, Cristina I. Muresan, Martine Neckebroek, Clara M. Ionescu
Publicado en: IEEE Transactions on Biomedical Engineering, Edición 70, 2024, ISSN 0018-9294
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TBME.2023.3274541

Fractional-Order Modeling of the Depth of Analgesia as Reference Model for Control Purposes

Autores: Cristina I. Muresan, Erwin T. Hegedüs, Marcian D. Mihai, Ghada Ben Othman, Isabela Birs, Dana Copot, Eva Henrietta Dulf, Robin De Keyser, Clara M. Ionescu, Martine Neckebroek
Publicado en: Fractal and Fractional, Edición 8, 2024, ISSN 2504-3110
Editor: MDPI AG
DOI: 10.3390/fractalfract8090539

Biomedical Signal Processing and Control

Autores: Mihaela Ghita, Isabela R. Birs, Dana Copot, Cristina I. Muresan, Clara M. Ionescu
Publicado en: Biomedical Signal Processing and Control, Edición 83, 2023, ISSN 1746-8094
Editor: Elsevier BV
DOI: 10.1016/J.BSPC.2023.104678

Sensors

Autores: Clara M. Ionescu; Dana Copot; Erhan Yumuk; Robin De Keyser; Cristina Muresan; Isabela Roxana Birs; Ghada Ben Othman; Hamed Farbakhsh; Amani R. Ynineb; Martine Neckebroek
Publicado en: Sensors, Vol 24, Iss 7, p 2031 (2024), 2024, ISSN 1424-8220
Editor: MDPI
DOI: 10.3390/S24072031

Journal of Process Control

Autores: Erhan Yumuk; Dana Copot; Clara M. Ionescu; Martine Neckebroek
Publicado en: JOURNAL OF PROCESS CONTROL, 2024, ISSN 0959-1524
Editor: ELSEVIER SCI LTD
DOI: 10.1016/j.jprocont.2024.103243