Adaptive Multi-Drug Infusion Control System for General Anesthesia in Major Surgery

Información del proyecto

AMICAS

Identificador del acuerdo de subvención: 101043225

DOI

10.3030/101043225

Fecha de la firma de la CE 18 Julio 2022

Fecha de inicio 1 Octubre 2022

Fecha de finalización 30 Septiembre 2027

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 1 927 325,00

Aportación de la UE

€ 1 927 325,00

Coordinado por

UNIVERSITEIT GENT
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (17)

Scientific Reports

Autores: Ynineb, Amani Rayene; Yumuk, Erhan; Copot, Dana; Ayvaz, Bora; Khoumeri, Bouchra; Ben Othman, Ghada; n D. Mihai, Marcian; Birs, Isabela Roxana; I. Muresan, Cristina; Ionescu, Clara
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/S41598-025-10172-1

A Novel Decentralized–Decoupled Fractional-Order Control Strategy for Complete Anesthesia–Hemodynamic Stabilization in Patients Undergoing Surgical Procedures

Autores: Erwin T. Hegedüs, Isabela R. Birs, Clara M. Ionescu, Cristina I. Muresan
Publicado en: Fractal and Fractional, Edición 8, 2024, ISSN 2504-3110
Editor: MDPI AG
DOI: 10.3390/FRACTALFRACT8110623

Journal of Advanced Research

Autores: Mihai, Marcian; Birs, Isabela Roxana; Hegedus, Erwin; Ynineb, Amani Rayene; Copot, Dana; De Keyser, Robain; Ionescu, Clara; Ladaci, Samir; Muresan, Cristina I.; Neckebroek, Martine
Publicado en: Journal of Advanced Research, Edición 78, 2025, ISSN 2090-1232
Editor: Elsevier
DOI: 10.1016/J.JARE.2025.03.053

Journal of Pharmacokinetics and Pharmacodynamics

Autores: Yumuk, Erhan; Ionescu, Clara
Publicado en: Journal of Pharmacokinetics and Pharmacodynamics, Edición 12, 2026, ISSN 1567-567X
Editor: Springer
DOI: 10.1007/S10928-026-10026-X

Model Extraction From Clinical Data Subject to Large Uncertainties and Poor Identifiability

Autores: Clara M. Ionescu, Robin De Keyser, Dana Copot, Erhan Yumuk, Amani Ynineb, Ghada Ben Othman, Martine Neckebroek
Publicado en: IEEE Control Systems Letters, Edición 8, 2024, ISSN 2475-1456
Editor: IEEE
DOI: 10.1109/LCSYS.2024.3402942

Modeling, analysis and experimental observations of fat volume properties in compartmental models for drug pharmacokinetics

Autores: Amani R. Ynineb; Bouchra Khoumeri; Erhan Yumuk; Bora Ayvaz; Ghada Ben Othman; Clara M. Ionescu; Dana Copot
Publicado en: Annual Reviews in Control, Edición 60, 2025, ISSN 1872-9088
Editor: Elsevier
DOI: 10.1016/J.ARCONTROL.2025.100996

Pharmacokinetic modelling during long-term anesthesia: minimizing the gap

Autores: Amani Rayene Ynineb, Erhan Yumuk, Dana Copot, Ghada Ben Othman, Hamed Farbakhsh, Isabela Roxana Birs, Robain De Keyser, Samir Ladaci, Cristina I. Muresan, Martine Neckebroek, et al.
Publicado en: Journal of Advanced Research, Edición 82, p.535-561, 2026, ISSN 2090-1224
Editor: Elsevier
DOI: 10.1016/J.JARE.2025.06.047

Parametric Modeling and Deep Learning for Enhancing Pain Assessment in Postanesthesia

Autores: Mihaela Ghita, Isabela R. Birs, Dana Copot, Cristina I. Muresan, Martine Neckebroek, Clara M. Ionescu
Publicado en: IEEE Transactions on Biomedical Engineering, Edición 70, 2024, ISSN 0018-9294
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TBME.2023.3274541

Physiological framework for non-invasive detection and objective nociception activity in communicative patients: a pilot case study

Autores: Ghada Ben Othman, Dana Copot, Bora Ayvaz, Robin De Keyser, Clara M. Ionescu
Publicado en: Frontiers in Physiology, Edición 16, 2026, ISSN 1664-042X
Editor: Frontiers Media SA
DOI: 10.3389/FPHYS.2025.1704303

Fractional-Order Modeling of the Depth of Analgesia as Reference Model for Control Purposes

Autores: Cristina I. Muresan, Erwin T. Hegedüs, Marcian D. Mihai, Ghada Ben Othman, Isabela Birs, Dana Copot, Eva Henrietta Dulf, Robin De Keyser, Clara M. Ionescu, Martine Neckebroek
Publicado en: Fractal and Fractional, Edición 8, 2024, ISSN 2504-3110
Editor: MDPI AG
DOI: 10.3390/fractalfract8090539

Biomedical Signal Processing and Control

Autores: Mihaela Ghita, Isabela R. Birs, Dana Copot, Cristina I. Muresan, Clara M. Ionescu
Publicado en: Biomedical Signal Processing and Control, Edición 83, 2023, ISSN 1746-8094
Editor: Elsevier BV
DOI: 10.1016/J.BSPC.2023.104678

Biomedical Signal Processing and Control

Autores: Bouchra Khoumeri; Dana Copot; Amani R. Ynineb; Bora Ayvaz; Ghada Ben Othman; Erhan Yumuk; Clara M. Ionescu
Publicado en: Biomedical Signal Processing and Control, Edición 109764, 2026, ISSN 1746-8094
Editor: Elsevier BV
DOI: 10.1016/J.BSPC.2026.109764

Information-Gated Truncated Unscented Kalman Filtering for Latent-State Estimation Under Poor Identifiability

Autores: Bouchra Khoumeri, Erwin Hegedus, Amani Ynineb, Bora Ayvaz, Dana Copot, Clara M. Ionescu
Publicado en: IEEE Control Systems Letters, Edición 10, 2026, ISSN 2475-1456
Editor: IEEE
DOI: 10.1109/LCSYS.2026.3715418

Sensors

Autores: Clara M. Ionescu; Dana Copot; Erhan Yumuk; Robin De Keyser; Cristina Muresan; Isabela Roxana Birs; Ghada Ben Othman; Hamed Farbakhsh; Amani R. Ynineb; Martine Neckebroek
Publicado en: Sensors, Vol 24, Iss 7, p 2031 (2024), 2024, ISSN 1424-8220
Editor: MDPI
DOI: 10.3390/S24072031

Journal of Process Control

Autores: Erhan Yumuk; Dana Copot; Clara M. Ionescu; Martine Neckebroek
Publicado en: JOURNAL OF PROCESS CONTROL, 2024, ISSN 0959-1524
Editor: ELSEVIER SCI LTD
DOI: 10.1016/j.jprocont.2024.103243

Systemic fragility in European total intravenous anesthesia delivery and opportunities for resilient real-time decision support

Autores: Clara Ionescu, Erhan Yumuk, Michele Schiavo, Antonio Visioli, Massimiliano Paltenghi, Nicola Latronico, Bob Aubouin Pairault, Mirko Fiacchini, Kaouther Moussa, Cristina Muresan, Isabela Birs, Eva Dulf, Teodora Mocan, Lucian Mocan, Robert Szabo, Dana Copot
Publicado en: Communications Medicine, Edición 6, 2026, ISSN 2730-664X
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S43856-026-01833-X

Event-based control of postoperative analgesia using physiological nociception signals

Autores: Bora Ayvaz, Ghada Ben Othman, Erhan Yumuk, Dana Copot, Clara M. Ionescu
Publicado en: Biomedical Signal Processing and Control, Edición 126, 2026, ISSN 1746-8094
Editor: Elsevier BV
DOI: 10.1016/J.BSPC.2026.110867

Conference proceedings (16)

Uncertainty Minimization and Feasibility Study for Managing the Complex and Interacting Anesthesia-Hemodynamic System

Autores: Ghita, Mihaela; Copot, Dana; Birs, Isabela R.; Muresan, Cristina I.; Keyser, Robin De; Neckebroek, Martine; Struys, Michel M.R.F.; Ionescu, Clara M.
Publicado en: IEEE 61st Conference on Decision and Control (CDC), 2022, ISSN 0743-1546
Editor: IEEE
DOI: 10.1109/cdc51059.2022.9992350

A compact fractional-order model for hypnosis in general anesthesia

Autores: Marcian Mihai , Isabela Roxana Birs, Erwin Hegedus , Dana Copot, Robain De Keyser, Clara-Mihaela Ionescu, Cristina Muresan and Martine Neckebroek
Publicado en: 12th IFAC Conference on Fractional Differentiation and its Application (ICFDA), 2024, ISSN 2405-8963
Editor: ELSEVIER
DOI: 10.1016/j.ifacol.2024.08.166

Analysis and Preliminary Results of a Feedback-Feedforward Controller for Depth of Anesthesia

Autores: Erwin Hegedus, Marcian D. Mihai, Isabela R. Birs, Hamed Farbakhsh, Erhan Yumuk, Dana Copot, Eva H. Dulf, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.037

A Compartmental Modelling Framework for Drug Distribution in Lean and Obese Patients in Long-Term General Anesthesia^*

Autores: Amani R. Ynineb, Erhan Yumuk, Hamed Farbakhsh, Ghada Ben Othman, Dana Copot, Isabela R. Birs, Cristina I. Muresan, Robin De Keyser, Samir Ladaci, Clara M. Ionescu, Martine Neckebroek
Publicado en: 2024 European Control Conference (ECC), 2024
Editor: IEEE
DOI: 10.23919/ECC64448.2024.10590971

Uncertainty and its Effect on Optimal Multidrug Control of Hemodynamic Variables

Autores: Teodora Popescu, Isabela R. Birs, Ghada Ben Othman, Erhan Yumuk, Marcian Mihai, Erwin Hegedus, Dana Copot, Robin De Keyser, Clara M. Ionescu, Cristina I. Muresan
Publicado en: 2024 American Control Conference (ACC), 2024
Editor: IEEE
DOI: 10.23919/ACC60939.2024.10644844

PID control of data-driven patient response with fixed ratio co-administration of drugs for depth of hypnosis

Autores: Clara M. Ionescu, Hamed Farbakhsh, Cristina Muresan, Robin De Keyser, Erhan Yumuk, Ghada Ben Othman, Amani Rayene Ynineb, Isabela Birs, Dana Copot, Martine Neckebroek
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.038

An adaptive control structure to mitigate lack of feasibility in systems with poor identifiability. Case Study on General Anesthesia

Autores: Clara M. Ionescu, Robin De Keyser, Erhan Yumuk, Dana Copot, Martine Neckebroek
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/J.IFACOL.2024.11.039

Comparative Analysis of Pharmacokinetic-Pharmacodynamic Models for Propofol and Remifentanil Using Model Predictive Control

Autores: A. R. Ynineb, H. Farbakhsh, G. Ben Othman, Y. Wahlquist, I. R. Birs, E. Yumuk, C. I. Muresan, R. De Keyser, D. Copot, C. M. Ionescu, M. Neckebroek
Publicado en: 2024 European Control Conference (ECC), 2024
Editor: IEEE
DOI: 10.23919/ECC64448.2024.10590766

A fractional order impedance model for heterogeneous drug distribution in obese patients during general anesthesia

Autores: Amani Rayene Ynineb, Erhan Yumuk, Hamed Farbakhs , Ghada Ben Othman , Dana Copot, Isabela Roxana Birs, Cristina Muresan, Robain De Keyser , Samir Ladaci, Clara-Mihaela Ionescu and Martine Neckebroek.
Publicado en: 12th IFAC Conference on Fractional Differentiation and its Application (ICFDA), 2024, ISSN 2405-8963
Editor: ELSEVIER
DOI: 10.1016/j.ifacol.2024.08.167

Model predictive control of hemodynamics during intravenous general anesthesia

Autores: Hamed Farbakhsh, Erhan Yumuk, Ghada Ben Othman, Robin De Keyser, Dana Copot, Isabela Birs, Clara M. Ionescu
Publicado en: 2023 27th International Conference on System Theory, Control and Computing (ICSTCC), 2023, ISSN 2473-5698
Editor: IEEE
DOI: 10.1109/icstcc59206.2023.10308441

Modelling of Blood Loss Influence on Propofol Concentrations and Anesthetic States in Critical Responses *

Autores: Mihaela Ghita, Dana Copot, Isabela Birs, Cristina Muresan, Martine Neckebroek, Clara Ionescu
Publicado en: 2023 American Control Conference (ACC), 2024, ISSN 0743-1619
Editor: IEEE
DOI: 10.23919/ACC55779.2023.10156356

Minimizing Epistemic Uncertainty for Predictive Control of General Anesthesia

Autores: Clara M. Ionescu, Robin De Keyser, Dana Copot, Erhan Yumuk, Isabela R. Birs, Erwin Hegedus, Cristina I. Muresan, Martine Neckebroek
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/J.IFACOL.2024.11.086

A Decoupled Fractional Order Control Strategy to Increase Patient Safety During Anesthesia-Hemodynamic Interactions

Autores: Erwin Hegedus, Marcian D. Mihai, Isabela R. Birs, Hamed Farbakhsh, Erhan Yumuk, Dana Copot, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Publicado en: 2024 European Control Conference (ECC), 2024
Editor: IEEE
DOI: 10.23919/ECC64448.2024.10591046

Inducing Anaesthesia via Exact Feedback Linearization control

Autores: Paul A. Pintea, Eva H. Dulf, Cristina I. Muresan, Clara M. Ionescu
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.069

Fractional Order PID Control of Propofol Dosage and Optimization in Lean and Obese Patients

Autores: Amani R. Ynineb, Marcian-David Mihai, Erhan Yumuk, Hamed Farbakhsh, Ghada Ben Othman, Robin De Keyser, Cristina Muresan, Isabela Birs, Dana Copot, Clara M. Ionescu
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.039

First-Hand Design of a Fractional order PID for Controlling the Depth of Hypnosis during Induction

Autores: Marcian Mihai, Isabela Birs, Hegedus Erwin, Dana Copot, Martine Neckebroek, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Publicado en: IFAC-PapersOnLine, Edición 58, 2024, ISSN 2405-8963
Editor: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.032