Adaptive Multi-Drug Infusion Control System for General Anesthesia in Major Surgery

Informazioni relative al progetto

AMICAS

ID dell’accordo di sovvenzione: 101043225

DOI

10.3030/101043225

Data della firma CE 18 Luglio 2022

Data di avvio 1 Ottobre 2022

Data di completamento 30 Settembre 2027

Finanziato da

• European Research Council (ERC)

Costo totale

€ 1 927 325,00

Contributo UE

€ 1 927 325,00

Coordinato da

UNIVERSITEIT GENT
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (17)

Scientific Reports

Autori: Ynineb, Amani Rayene; Yumuk, Erhan; Copot, Dana; Ayvaz, Bora; Khoumeri, Bouchra; Ben Othman, Ghada; n D. Mihai, Marcian; Birs, Isabela Roxana; I. Muresan, Cristina; Ionescu, Clara
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/S41598-025-10172-1

A Novel Decentralized–Decoupled Fractional-Order Control Strategy for Complete Anesthesia–Hemodynamic Stabilization in Patients Undergoing Surgical Procedures

Autori: Erwin T. Hegedüs, Isabela R. Birs, Clara M. Ionescu, Cristina I. Muresan
Pubblicato in: Fractal and Fractional, Numero 8, 2024, ISSN 2504-3110
Editore: MDPI AG
DOI: 10.3390/FRACTALFRACT8110623

Journal of Advanced Research

Autori: Mihai, Marcian; Birs, Isabela Roxana; Hegedus, Erwin; Ynineb, Amani Rayene; Copot, Dana; De Keyser, Robain; Ionescu, Clara; Ladaci, Samir; Muresan, Cristina I.; Neckebroek, Martine
Pubblicato in: Journal of Advanced Research, Numero 78, 2025, ISSN 2090-1232
Editore: Elsevier
DOI: 10.1016/J.JARE.2025.03.053

Journal of Pharmacokinetics and Pharmacodynamics

Autori: Yumuk, Erhan; Ionescu, Clara
Pubblicato in: Journal of Pharmacokinetics and Pharmacodynamics, Numero 12, 2026, ISSN 1567-567X
Editore: Springer
DOI: 10.1007/S10928-026-10026-X

Model Extraction From Clinical Data Subject to Large Uncertainties and Poor Identifiability

Autori: Clara M. Ionescu, Robin De Keyser, Dana Copot, Erhan Yumuk, Amani Ynineb, Ghada Ben Othman, Martine Neckebroek
Pubblicato in: IEEE Control Systems Letters, Numero 8, 2024, ISSN 2475-1456
Editore: IEEE
DOI: 10.1109/LCSYS.2024.3402942

Modeling, analysis and experimental observations of fat volume properties in compartmental models for drug pharmacokinetics

Autori: Amani R. Ynineb; Bouchra Khoumeri; Erhan Yumuk; Bora Ayvaz; Ghada Ben Othman; Clara M. Ionescu; Dana Copot
Pubblicato in: Annual Reviews in Control, Numero 60, 2025, ISSN 1872-9088
Editore: Elsevier
DOI: 10.1016/J.ARCONTROL.2025.100996

Pharmacokinetic modelling during long-term anesthesia: minimizing the gap

Autori: Amani Rayene Ynineb, Erhan Yumuk, Dana Copot, Ghada Ben Othman, Hamed Farbakhsh, Isabela Roxana Birs, Robain De Keyser, Samir Ladaci, Cristina I. Muresan, Martine Neckebroek, et al.
Pubblicato in: Journal of Advanced Research, Numero 82, p.535-561, 2026, ISSN 2090-1224
Editore: Elsevier
DOI: 10.1016/J.JARE.2025.06.047

Parametric Modeling and Deep Learning for Enhancing Pain Assessment in Postanesthesia

Autori: Mihaela Ghita, Isabela R. Birs, Dana Copot, Cristina I. Muresan, Martine Neckebroek, Clara M. Ionescu
Pubblicato in: IEEE Transactions on Biomedical Engineering, Numero 70, 2024, ISSN 0018-9294
Editore: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TBME.2023.3274541

Physiological framework for non-invasive detection and objective nociception activity in communicative patients: a pilot case study

Autori: Ghada Ben Othman, Dana Copot, Bora Ayvaz, Robin De Keyser, Clara M. Ionescu
Pubblicato in: Frontiers in Physiology, Numero 16, 2026, ISSN 1664-042X
Editore: Frontiers Media SA
DOI: 10.3389/FPHYS.2025.1704303

Fractional-Order Modeling of the Depth of Analgesia as Reference Model for Control Purposes

Autori: Cristina I. Muresan, Erwin T. Hegedüs, Marcian D. Mihai, Ghada Ben Othman, Isabela Birs, Dana Copot, Eva Henrietta Dulf, Robin De Keyser, Clara M. Ionescu, Martine Neckebroek
Pubblicato in: Fractal and Fractional, Numero 8, 2024, ISSN 2504-3110
Editore: MDPI AG
DOI: 10.3390/fractalfract8090539

Biomedical Signal Processing and Control

Autori: Mihaela Ghita, Isabela R. Birs, Dana Copot, Cristina I. Muresan, Clara M. Ionescu
Pubblicato in: Biomedical Signal Processing and Control, Numero 83, 2023, ISSN 1746-8094
Editore: Elsevier BV
DOI: 10.1016/J.BSPC.2023.104678

Biomedical Signal Processing and Control

Autori: Bouchra Khoumeri; Dana Copot; Amani R. Ynineb; Bora Ayvaz; Ghada Ben Othman; Erhan Yumuk; Clara M. Ionescu
Pubblicato in: Biomedical Signal Processing and Control, Numero 109764, 2026, ISSN 1746-8094
Editore: Elsevier BV
DOI: 10.1016/J.BSPC.2026.109764

Information-Gated Truncated Unscented Kalman Filtering for Latent-State Estimation Under Poor Identifiability

Autori: Bouchra Khoumeri, Erwin Hegedus, Amani Ynineb, Bora Ayvaz, Dana Copot, Clara M. Ionescu
Pubblicato in: IEEE Control Systems Letters, Numero 10, 2026, ISSN 2475-1456
Editore: IEEE
DOI: 10.1109/LCSYS.2026.3715418

Sensors

Autori: Clara M. Ionescu; Dana Copot; Erhan Yumuk; Robin De Keyser; Cristina Muresan; Isabela Roxana Birs; Ghada Ben Othman; Hamed Farbakhsh; Amani R. Ynineb; Martine Neckebroek
Pubblicato in: Sensors, Vol 24, Iss 7, p 2031 (2024), 2024, ISSN 1424-8220
Editore: MDPI
DOI: 10.3390/S24072031

Journal of Process Control

Autori: Erhan Yumuk; Dana Copot; Clara M. Ionescu; Martine Neckebroek
Pubblicato in: JOURNAL OF PROCESS CONTROL, 2024, ISSN 0959-1524
Editore: ELSEVIER SCI LTD
DOI: 10.1016/j.jprocont.2024.103243

Systemic fragility in European total intravenous anesthesia delivery and opportunities for resilient real-time decision support

Autori: Clara Ionescu, Erhan Yumuk, Michele Schiavo, Antonio Visioli, Massimiliano Paltenghi, Nicola Latronico, Bob Aubouin Pairault, Mirko Fiacchini, Kaouther Moussa, Cristina Muresan, Isabela Birs, Eva Dulf, Teodora Mocan, Lucian Mocan, Robert Szabo, Dana Copot
Pubblicato in: Communications Medicine, Numero 6, 2026, ISSN 2730-664X
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S43856-026-01833-X

Event-based control of postoperative analgesia using physiological nociception signals

Autori: Bora Ayvaz, Ghada Ben Othman, Erhan Yumuk, Dana Copot, Clara M. Ionescu
Pubblicato in: Biomedical Signal Processing and Control, Numero 126, 2026, ISSN 1746-8094
Editore: Elsevier BV
DOI: 10.1016/J.BSPC.2026.110867

Conference proceedings (16)

Uncertainty Minimization and Feasibility Study for Managing the Complex and Interacting Anesthesia-Hemodynamic System

Autori: Ghita, Mihaela; Copot, Dana; Birs, Isabela R.; Muresan, Cristina I.; Keyser, Robin De; Neckebroek, Martine; Struys, Michel M.R.F.; Ionescu, Clara M.
Pubblicato in: IEEE 61st Conference on Decision and Control (CDC), 2022, ISSN 0743-1546
Editore: IEEE
DOI: 10.1109/cdc51059.2022.9992350

A compact fractional-order model for hypnosis in general anesthesia

Autori: Marcian Mihai , Isabela Roxana Birs, Erwin Hegedus , Dana Copot, Robain De Keyser, Clara-Mihaela Ionescu, Cristina Muresan and Martine Neckebroek
Pubblicato in: 12th IFAC Conference on Fractional Differentiation and its Application (ICFDA), 2024, ISSN 2405-8963
Editore: ELSEVIER
DOI: 10.1016/j.ifacol.2024.08.166

Analysis and Preliminary Results of a Feedback-Feedforward Controller for Depth of Anesthesia

Autori: Erwin Hegedus, Marcian D. Mihai, Isabela R. Birs, Hamed Farbakhsh, Erhan Yumuk, Dana Copot, Eva H. Dulf, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Pubblicato in: IFAC-PapersOnLine, Numero 58, 2024, ISSN 2405-8963
Editore: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.037

A Compartmental Modelling Framework for Drug Distribution in Lean and Obese Patients in Long-Term General Anesthesia^*

Autori: Amani R. Ynineb, Erhan Yumuk, Hamed Farbakhsh, Ghada Ben Othman, Dana Copot, Isabela R. Birs, Cristina I. Muresan, Robin De Keyser, Samir Ladaci, Clara M. Ionescu, Martine Neckebroek
Pubblicato in: 2024 European Control Conference (ECC), 2024
Editore: IEEE
DOI: 10.23919/ECC64448.2024.10590971

Uncertainty and its Effect on Optimal Multidrug Control of Hemodynamic Variables

Autori: Teodora Popescu, Isabela R. Birs, Ghada Ben Othman, Erhan Yumuk, Marcian Mihai, Erwin Hegedus, Dana Copot, Robin De Keyser, Clara M. Ionescu, Cristina I. Muresan
Pubblicato in: 2024 American Control Conference (ACC), 2024
Editore: IEEE
DOI: 10.23919/ACC60939.2024.10644844

PID control of data-driven patient response with fixed ratio co-administration of drugs for depth of hypnosis

Autori: Clara M. Ionescu, Hamed Farbakhsh, Cristina Muresan, Robin De Keyser, Erhan Yumuk, Ghada Ben Othman, Amani Rayene Ynineb, Isabela Birs, Dana Copot, Martine Neckebroek
Pubblicato in: IFAC-PapersOnLine, Numero 58, 2024, ISSN 2405-8963
Editore: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.038

An adaptive control structure to mitigate lack of feasibility in systems with poor identifiability. Case Study on General Anesthesia

Autori: Clara M. Ionescu, Robin De Keyser, Erhan Yumuk, Dana Copot, Martine Neckebroek
Pubblicato in: IFAC-PapersOnLine, Numero 58, 2024, ISSN 2405-8963
Editore: Elsevier BV
DOI: 10.1016/J.IFACOL.2024.11.039

Comparative Analysis of Pharmacokinetic-Pharmacodynamic Models for Propofol and Remifentanil Using Model Predictive Control

Autori: A. R. Ynineb, H. Farbakhsh, G. Ben Othman, Y. Wahlquist, I. R. Birs, E. Yumuk, C. I. Muresan, R. De Keyser, D. Copot, C. M. Ionescu, M. Neckebroek
Pubblicato in: 2024 European Control Conference (ECC), 2024
Editore: IEEE
DOI: 10.23919/ECC64448.2024.10590766

A fractional order impedance model for heterogeneous drug distribution in obese patients during general anesthesia

Autori: Amani Rayene Ynineb, Erhan Yumuk, Hamed Farbakhs , Ghada Ben Othman , Dana Copot, Isabela Roxana Birs, Cristina Muresan, Robain De Keyser , Samir Ladaci, Clara-Mihaela Ionescu and Martine Neckebroek.
Pubblicato in: 12th IFAC Conference on Fractional Differentiation and its Application (ICFDA), 2024, ISSN 2405-8963
Editore: ELSEVIER
DOI: 10.1016/j.ifacol.2024.08.167

Model predictive control of hemodynamics during intravenous general anesthesia

Autori: Hamed Farbakhsh, Erhan Yumuk, Ghada Ben Othman, Robin De Keyser, Dana Copot, Isabela Birs, Clara M. Ionescu
Pubblicato in: 2023 27th International Conference on System Theory, Control and Computing (ICSTCC), 2023, ISSN 2473-5698
Editore: IEEE
DOI: 10.1109/icstcc59206.2023.10308441

Modelling of Blood Loss Influence on Propofol Concentrations and Anesthetic States in Critical Responses *

Autori: Mihaela Ghita, Dana Copot, Isabela Birs, Cristina Muresan, Martine Neckebroek, Clara Ionescu
Pubblicato in: 2023 American Control Conference (ACC), 2024, ISSN 0743-1619
Editore: IEEE
DOI: 10.23919/ACC55779.2023.10156356

Minimizing Epistemic Uncertainty for Predictive Control of General Anesthesia

Autori: Clara M. Ionescu, Robin De Keyser, Dana Copot, Erhan Yumuk, Isabela R. Birs, Erwin Hegedus, Cristina I. Muresan, Martine Neckebroek
Pubblicato in: IFAC-PapersOnLine, Numero 58, 2024, ISSN 2405-8963
Editore: Elsevier BV
DOI: 10.1016/J.IFACOL.2024.11.086

A Decoupled Fractional Order Control Strategy to Increase Patient Safety During Anesthesia-Hemodynamic Interactions

Autori: Erwin Hegedus, Marcian D. Mihai, Isabela R. Birs, Hamed Farbakhsh, Erhan Yumuk, Dana Copot, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Pubblicato in: 2024 European Control Conference (ECC), 2024
Editore: IEEE
DOI: 10.23919/ECC64448.2024.10591046

Inducing Anaesthesia via Exact Feedback Linearization control

Autori: Paul A. Pintea, Eva H. Dulf, Cristina I. Muresan, Clara M. Ionescu
Pubblicato in: IFAC-PapersOnLine, Numero 58, 2024, ISSN 2405-8963
Editore: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.069

Fractional Order PID Control of Propofol Dosage and Optimization in Lean and Obese Patients

Autori: Amani R. Ynineb, Marcian-David Mihai, Erhan Yumuk, Hamed Farbakhsh, Ghada Ben Othman, Robin De Keyser, Cristina Muresan, Isabela Birs, Dana Copot, Clara M. Ionescu
Pubblicato in: IFAC-PapersOnLine, Numero 58, 2024, ISSN 2405-8963
Editore: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.039

First-Hand Design of a Fractional order PID for Controlling the Depth of Hypnosis during Induction

Autori: Marcian Mihai, Isabela Birs, Hegedus Erwin, Dana Copot, Martine Neckebroek, Robain De Keyser, Clara M. Ionescu, Cristina I. Muresan
Pubblicato in: IFAC-PapersOnLine, Numero 58, 2024, ISSN 2405-8963
Editore: Elsevier BV
DOI: 10.1016/j.ifacol.2024.08.032