Emerging multifactorial complexity at the geminivirus-host interface

Información del proyecto

GemOmics

Identificador del acuerdo de subvención: 101044142

DOI

10.3030/101044142

Fecha de la firma de la CE 27 Abril 2022

Fecha de inicio 1 Julio 2022

Fecha de finalización 30 Junio 2027

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 1 999 973,00

Aportación de la UE

€ 1 999 973,00

Coordinado por

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

Periodic Reporting for period 1 - GemOmics (Emerging multifactorial complexity at the geminivirus-host interface)

Período documentado: 2022-07-01 hasta 2024-12-31

Resumen del contexto y de los objetivos generales del proyecto

Viruses manipulate their host cells to replicate and spread, ultimately causing devastating diseases in the organisms they infect. This manipulation is based on the activity of virus-encoded proteins, limited due to restrictions in genome size imposed by the viral cycle. How the action of these few proteins results in the massive cell reprogramming observed during the infection remains enigmatic. This project tackles this question by using geminiviruses, plant viruses infecting crops worldwide, as models. We aim to define the complete set of proteins these viruses produce, and investigate how they interact, physically and functionally, with the cellular proteins and with one another, generating a comprehensive map of the virus/host intersection with unprecedented resolution. Then, we plant to test if these maps are similar in different virus/host interactions.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

Our results so far indicate that viruses produce more proteins with roles in the infection than previously thought, and that some of these proteins physically interact with themselves and/or one another, which could expand their functional capabilities.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

The conceptual and practical enlargement of the virus/host interface elucidated in this project suggests that we are currently just scratching at the surface of virus-host interactions.

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