Emerging multifactorial complexity at the geminivirus-host interface

Informazioni relative al progetto

GemOmics

ID dell’accordo di sovvenzione: 101044142

DOI

10.3030/101044142

Data della firma CE 27 Aprile 2022

Data di avvio 1 Luglio 2022

Data di completamento 30 Giugno 2027

Finanziato da

• European Research Council (ERC)

Costo totale

€ 1 999 973,00

Contributo UE

€ 1 999 973,00

Coordinato da

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

Periodic Reporting for period 1 - GemOmics (Emerging multifactorial complexity at the geminivirus-host interface)

Periodo di rendicontazione: 2022-07-01 al 2024-12-31

Sintesi del contesto e degli obiettivi generali del progetto

Viruses manipulate their host cells to replicate and spread, ultimately causing devastating diseases in the organisms they infect. This manipulation is based on the activity of virus-encoded proteins, limited due to restrictions in genome size imposed by the viral cycle. How the action of these few proteins results in the massive cell reprogramming observed during the infection remains enigmatic. This project tackles this question by using geminiviruses, plant viruses infecting crops worldwide, as models. We aim to define the complete set of proteins these viruses produce, and investigate how they interact, physically and functionally, with the cellular proteins and with one another, generating a comprehensive map of the virus/host intersection with unprecedented resolution. Then, we plant to test if these maps are similar in different virus/host interactions.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

Our results so far indicate that viruses produce more proteins with roles in the infection than previously thought, and that some of these proteins physically interact with themselves and/or one another, which could expand their functional capabilities.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

The conceptual and practical enlargement of the virus/host interface elucidated in this project suggests that we are currently just scratching at the surface of virus-host interactions.

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