Emerging multifactorial complexity at the geminivirus-host interface

Informations projet

GemOmics

N° de convention de subvention: 101044142

DOI

10.3030/101044142

Date de signature de la CE 27 Avril 2022

Date de début 1 Juillet 2022

Date de fin 30 Juin 2027

Financé au titre de

• European Research Council (ERC)

Coût total

€ 1 999 973,00

Contribution de l’UE

€ 1 999 973,00

Coordonné par

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

Periodic Reporting for period 1 - GemOmics (Emerging multifactorial complexity at the geminivirus-host interface)

Période du rapport: 2022-07-01 au 2024-12-31

Résumé du contexte et des objectifs généraux du projet

Viruses manipulate their host cells to replicate and spread, ultimately causing devastating diseases in the organisms they infect. This manipulation is based on the activity of virus-encoded proteins, limited due to restrictions in genome size imposed by the viral cycle. How the action of these few proteins results in the massive cell reprogramming observed during the infection remains enigmatic. This project tackles this question by using geminiviruses, plant viruses infecting crops worldwide, as models. We aim to define the complete set of proteins these viruses produce, and investigate how they interact, physically and functionally, with the cellular proteins and with one another, generating a comprehensive map of the virus/host intersection with unprecedented resolution. Then, we plant to test if these maps are similar in different virus/host interactions.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

Our results so far indicate that viruses produce more proteins with roles in the infection than previously thought, and that some of these proteins physically interact with themselves and/or one another, which could expand their functional capabilities.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

The conceptual and practical enlargement of the virus/host interface elucidated in this project suggests that we are currently just scratching at the surface of virus-host interactions.

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