Emerging multifactorial complexity at the geminivirus-host interface

Projektinformationen

GemOmics

ID Finanzhilfevereinbarung: 101044142

DOI

10.3030/101044142

EK-Unterschriftsdatum 27 April 2022

Startdatum 1 Juli 2022

Enddatum 30 Juni 2027

Finanziert unter

• European Research Council (ERC)

Gesamtkosten

€ 1 999 973,00

EU-Beitrag

€ 1 999 973,00

Koordiniert durch

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

Periodic Reporting for period 1 - GemOmics (Emerging multifactorial complexity at the geminivirus-host interface)

Berichtszeitraum: 2022-07-01 bis 2024-12-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Viruses manipulate their host cells to replicate and spread, ultimately causing devastating diseases in the organisms they infect. This manipulation is based on the activity of virus-encoded proteins, limited due to restrictions in genome size imposed by the viral cycle. How the action of these few proteins results in the massive cell reprogramming observed during the infection remains enigmatic. This project tackles this question by using geminiviruses, plant viruses infecting crops worldwide, as models. We aim to define the complete set of proteins these viruses produce, and investigate how they interact, physically and functionally, with the cellular proteins and with one another, generating a comprehensive map of the virus/host intersection with unprecedented resolution. Then, we plant to test if these maps are similar in different virus/host interactions.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

Our results so far indicate that viruses produce more proteins with roles in the infection than previously thought, and that some of these proteins physically interact with themselves and/or one another, which could expand their functional capabilities.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

The conceptual and practical enlargement of the virus/host interface elucidated in this project suggests that we are currently just scratching at the surface of virus-host interactions.

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