Descrizione del progetto
Un impianto retinico non invasivo
Un’interfaccia cervello-computer è un dispositivo di comunicazione che acquisisce segnali cerebrali e traduce informazioni neuronali in comandi. Nonostante l’immenso potenziale di queste soluzioni, le loro prestazioni non sono tuttora ottimali a causa di difficoltà tecniche. Il progetto Outer-Ret, finanziato dal Consiglio europeo della ricerca, concentrerà l’attenzione sugli impianti retinici quali strumenti per trattare le malattie degenerative della retina. L’obiettivo principale è quello di migliorare la neurostimolazione retinica e sviluppare un approccio non invasivo per generare la visione artificiale. I risultati forniranno indizi fondamentali sulla biologia della retina e consentiranno di far progredire le attuali strategie per offrire visione funzionale ai pazienti affetti da malattie degenerative della retina.
Obiettivo
Retinal implants remain one of the most demanding technologies in brain-machine interfacing. State of the art devices have yet to reach the needed performances. Main barriers are sub-optimal stimulation parameters and long development and testing procedures. While invasive approaches, have yet to achieve the resolution performances needed by million of patients blinded by retinal degenerative diseases, non-invasive approaches in the form of trans-orbital stimulation have received no attention, yet they offer potentially dramatically cheaper and easy to adapt and optimize technology. The main goal of this project is to advance the field of retina neurostimulation by developing new tools for the study and interfacing with the retina. In particular: (1) Bi-directional electrophysiological interface which can record and stimulate the intact retina (in the eye) and (2) soft multi-electrode arrays for non-invasive stimulation of the retina (soft trans-orbital electrodes) will be explored. We will use these tools to study the retina in its intact form (in animal models) and we will implement the gained know-how in humans to study non-invasive stimulation. In this project we will establish a new platform for bi-directional electrophysiological interfacing with the intact retina and we will use it to study the retina in its intact form. Such investigations have ground breaking nature as they can advance both the fundamental understanding of the retina and improve the manner by which we stimulate the retina to generate artificial vision: Specifically, we aim to record spontaneous waves activity and light sensitive ganglion cells, optimize electrical stimulation parameters in the intact retina, and ultimately to measure retina responses to trans-orbit stimulation. As the ultimate goal of the project, we aim to establish the foundation of trans-orbital stimulation as a new non-invasive paradigm for functional vision in patient suffering from retina degenerative diseases.
Campo scientifico
Programma(i)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Argomento(i)
Meccanismo di finanziamento
ERC - Support for frontier research (ERC)Istituzione ospitante
69978 Tel Aviv
Israele